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Tag: "defects" at biology news

Neuronal 'traffic jam' marks early Alzheimer's disease

...eta amyloid precursor protein (beta-APP), triggers defects in axonal transport. A defective version of beta-A... syndrome where beta-APP is overexpressed -- those defects cause early failure in cellular transport," he said. "And those failures then stimulate further prod...

Same mutation aided evolution in many fish species, Stanford study finds

...in mice similar alterations can also be created by defects in any one of three different genes. "Based on the mouse work you'd predict we would find mutations in any of the three genes in sticklebacks," said Kingsley, who is also a Howard Hughes Medical Institute investigator. "That's not what we see." Inst...

Zebrafish may hold key to understanding human nerve cell development

...can also visually identifythe consequences of gene defects in the 200 to 300 embryos each femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migrati...

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...can also visually identifythe consequences of gene defects in the 200 to 300 embryos each femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migrati...

GenMAPP 2.0 released

...can also visually identifythe consequences of gene defects in the 200 to 300 embryos each femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migrati...

Beyond lithium for bipolar disorder

...ich the gene is knocked out show hyperactivity and defects in their circadian (day-night) behavior--both also characteristic of humans with bipolar disorder. Also, in animals, lithium has been shown to affect such circadian behavior. The protein also has been found to affect the activity of a key neurotransm...

NJIT Presidential Award winner takes stem cell research another step

...t patients suffering from bone fractures and other defects that may not heal because they are also suffering from other disorders. We are looking at the current treatment for repairing bone defects, which is the use of allograft tissue, as well as newer treatments such as combining allograft with stem cells....

UCSD team discovers specialized, rare heart stem cells in newborns

...can insure the closure of any existing small heart defects and the formation of a completely mature heart in newborns." The UCSD team noted in the Nature paper that the next research steps with the isl1+ cells will be cellular transplantation in living animals to study their role in endogenous repair after ...

Effective Cancer Treatments Follow The Clock

...may respond to drug treatment,?said Antoch. “Thus, defects in Clock or Bmal1 genes, which essentially damp th...may produce very different effect when compared to defects in Cryptochrome gene, which, in contrast, `jams' the circadian clock at the most active point in its...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...ioxide. Those findings suggested that nitric oxide defects might play a role in the cardiovascular side effects of many disorders, including diabetes, heart attacks, septic shock and sickle cell disease. In the current study, the researchers found that hemoglobin in the red cells of patients with sickle cel...

Gene therapy promising for growing tooth-supporting bone

...bone morphogenetic protein-7 (BMP-7) to large bone defects in rats in an attempt to turn on the body's own bone growth mechanisms. The study showed that animals that got the BMP-7 treatment produced nearly 50 percent more supporting bone around dental implants than those receiving the conventional treatment....

Cerebral navigation: How do nerve fibers know what direction to grow in?

...signal, the mice had abnormal axon projections and defects in neural circuitry formation. The second paper demonstrates the role of a protein called ephexin1 in axon guidance. By itself, ephexin 1 promotes axon growth; neurons from mice genetically modified to lack ephexin1 had significantly shorter axons. ...

Cellular Defects in Premature Aging Disease are Reversible

...the abnormalities seen in HGPS cells by correcting defects associated with the key protein, lamin A. By demonstrating that HGPS cellular characteristics are reversible, this study, appearing in Nature Medicine online on March 6, 2005, brings scientists one step closer to understanding this devastating childh...

Of mice and men's (and women's) contraceptives

...nal sperm, and females show early loss of eggs and defects in ovulation. The MSY2 protein is part of a family of proteins, called Y-box proteins, that are present in most organisms, ranging from bacteria to humans. In the nuclei of developing germ cells, MSY2 enhances synthesis of a select group of messenge...

Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid

...uid to test for hereditary diseases and congenital defects in the fetus). "After extraction from the normally discarded fraction of amniotic fluid, RNA was amplified twice, labeled, and analyzed using gene expression microarrays." The researchers were able to study the expression of developmental transcripts...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

...lications for the treatment of liver-based genetic defects such as hemophilia A and B in humans. Mouse embryonic stem cells treated in culture with a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, the new study shows. A report of the ...

Determining The Fate Of Cells In The Human Body

...ediatrics perspective -- there are many congenital defects - holes in the heart, cleft pallet, webbed hands -- which are outcomes of inappropriate molecular programs due to miscommunication at the cellular level. If we can understand what is going wrong, we may be able to correct these problems before birth,...

UI researcher studies deafness in fruit flies, humans

...lleagues at Duke University have uncovered genetic defects leading to deafness in fruit flies that may shed light on deafness in humans. Their research paper, "Myosin VIIA Defects, which Underlie the Usher 1B Syndrome in Humans, Lead to Deafness in Drosophila," is scheduled for publication in the May 10 issu...

Genetic links could unlock clues to leading cause of blindness

...uld be the first step toward repairing the genetic defects linked to it. According to the National Eye Institute, nearly 2 million Americans have advanced age-related macular degeneration, a disease that develops when a small, light-detecting part of the retina called the macula breaks down. Seven million m...

Decisions, decisions: Male or female?

...ings could eventually help us understand and treat defects in germ cell development that lead to human infertility and disease." ...

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