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Tag: "defect" at biology news

Fox Chase Cancer Center scientists identify immune-system mutation

... discovered the mice with this naturally occurring defect in Fox Chase's laboratory animal facility in 1997....ller-cell pathway. "Our new study identifies this defect as a point mutation in the zinc finger transcription factor Th-POK. We show that when the normal for...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...e called "feeder cells" from mice with ahuman-like defect in Neu5Gc production. They noted that they haverecently produced such a mouse. Another possibility being attempted bygroups in other parts of the world is to use human embryo-derivedconnective tissue cells as the feeder layer in the culture.A further...

Enzyme allows B cells to resist death, leading to leukemia

...gesof disease, B-CLL is the result of an undefined defect in theprogrammed signals that trigger normal B cell death (apoptosis). LivioTrentin and colleagues from Padua University School of Medicine nowdemonstrate that high levels of expression and altered cellularlocation of an enzyme in B cells known as Ly...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...r dystrophies. Patients with Pompe disease have a defect in a key enzyme that converts glycogen, a stored form of sugar, into glucose, the body's primary energy source. As a result, glycogen builds up in muscles throughout the body, including the heart, causing muscles to degenerate. Using genetically alt...

Critical role in programmed cell death identified

...l death is essential and animals with a cell death defect die. The researchers demonstrated that when they cause worm mitochondria to fragment without instructing cells to die, the cells still die and when they block fragmentation, the cells survive; in other words, blocking fragmentation prevents cell dea...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...d cells." The finding marks the first time that a defect in the ability of patients' red blood cells to process nitric oxide has been linked to a disease, the researchers said. The findings also raise the possibility that defective nitric oxide processing by red blood cells may represent a new class of blo...

Gene therapy promising for growing tooth-supporting bone

...viral approaches to delivering gene therapy to the defect site. Alternatively, scientists could conduct the gene therapy outside the body using a tissue biopsy and then transplant the genetically-modified cells back into the patient, but this would require two surgical procedures instead of one. The Molecu...

Harmful chemicals may reprogram gene response to estrogen

...e researchers used a special strain of rats with a defect in a gene called Tsc-2 (tuberous sclerosis complex... factors. A 2003 study of Jewish women born with a defect in BRCA1, the gene that is linked to inherited forms of breast and ovarian cancer, showed that those...

Same-Sex Mating Discovered in a Toxic Fungus

...er genes with known roles in mating -- exhibited a defect in fruiting. The newly described mating strategy might allow a single mating strain to expand rapidly by cell division, yet retain its ability to generate diversity by undergoing sex, said Heitman. That diversity might provide an advantage when face...

Genetic defects give the immune system the green light to attack the pancreas

...uya Yamagata, M.D., Ph.D, from Japan. The genetic defect keeps the body from properly dealing with “errant?immune cells that it normally eliminates by a process called immunological tolerance. These immune cells then attack the insulin-producing beta cells in the pancreas, mistaking them as foreign invader...

New tumor-suppressor gene discovered

...ene to tumor-plagued flies known to have a genetic defect in their mats gene, then found that tumors no long...that these flies had a naturally occurring genetic defect that caused them to develop the tumors. He used genetic-mapping techniques to study the mutant fly's...

UCSD research reveals mechanism involved with type of fatal epilepsy

...tients. Thus, researchers have long thought that a defect in glycogen metabolism is intimately linked to the disease. Recessive mutations in two genes have been shown to cause Lafora disease. The genes encode the proteins laforin and malin, but the molecular mechanism defining how loss of laforin or malin c...

Tendency to hair loss inherited from the mother

...her's side rather than their father. However, this defect is not simply caused by one gene: "We have indicat...rents' sex," Prof. Nöthen stresses. The hereditary defect can therefore sometimes also be passed on directly from father to son. Bald men wanted In order to ...

Important discovery about second most fatal cancer

...sk population. 3. An understanding of the genetic defect may provide important insight into the basic cause of the common non-inherited forms of the same type of cancer. The findings of Dr. Jass and his colleagues are reported in the March 2005 edition of Clinical Gastroenterology and Hepatology, publishe...

Researchers pioneer new gene therapy technique using natural repair process

...rt of therapy because you only need to correct the defect in a small number of immune cells to fix the problem," said Dr. Porteus, assistant professor of pediatrics and biochemistry at UT Southwestern. "This is called selective advantage; the healthy cells grow and divide preferentially over the mutant ones...

Attacks of King George III's madness linked to key metabolism molecule

...hat's crucial to the normal manufacture of heme. A defect in this genetic signaling pathway could cause ALAS-1 to accumulate in high levels, leading to the symptoms of porphyria attacks. "We found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver," the...

Fruit fly studies open new window on cancer research

...tion of the transporters was so significant that a defect in one of them reduces a fly's growth by about half. Dr Deborah Goberdhan, one of the researchers involved, said, "We are now looking at whether human equivalents of these fruit fly genes act in the same way. If they do, then new drugs or even diet...

The synapse is a shotgun

...as myasthenia gravis, a common disorder in which a defect in nerve impulse transmission results in muscle weakness. In this and other neurological diseases, "there may be an anomaly at the receptor level, but it is impossible to pinpoint the problem with existing techniques. With our modeling technique, we ...

Defect in gene causes 'neuralgic amyotrophy'

...n and Peter De Jonghe, have discovered the genetic defect that underlies HNA. In this effort, the researcher...HNA is the first mono-genetic disorder caused by a defect in a gene of the Septin family. The researchers do not yet know exactly how Septin 9 functions in t...

Change in gene may be underlying molecular defect in some colorectal cancers

...olecular defect. The molecular basis for the field defect is easy to understand when tumors develop from cel...ogen such as tobacco smoke. However, how the field defect may arise in most sporadic cancers in unclear. In colorectal cancer, the DNA repair gene O 6 -methy...

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(Date:7/11/2014)... transplantation of mesenchymal stem cells can stimulate neurogenesis in ... Alzheimer,s disease (AD) and improve tissue and function injury ... reported on the therapeutic effect of adipose-derived stem cells ... effect on oxidative injury and neurogenesis in the brain ... School of Life Sciences, Tsinghua University, China transplanted ADSCs ...
(Date:7/11/2014)... hippocampus, the marginal division of the striatum is ... the impact degree of substance P in the ... Yan Yu and his team, College of Biophotonics, ... staining, that substance P receptor, neurokinin 1 was ... division of normal rats. Unilateral or bilateral injection ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):
(Date:7/11/2014)... 11, 2014 When the mercury rises, heat ... driving engine, the heart, takes on a heavier load in ... July 2014 issue of the Harvard Men's Health Watch ... requires no more than knowing their limits and drinking enough ... going to be more sensitive to the heat," says Dr. ...
(Date:7/11/2014)... Angeles, CA (PRWEB) July 11, 2014 ... Sands today announces that he uses mini and full ... treatments offer the defining feature that distinguishes dental implants ... teeth in addition to the crowns. This alone prevents ... implants also offer advantages related to comfort, appearance ...
(Date:7/11/2014)... -- A new study challenges the widely held belief that ... Researchers analyzed more than 50 studies that examined drinking ... They found that those with a form of a gene ... The gene affects how a person,s body breaks down alcohol, ... Having this variant has been shown to lead to lower ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Cancer researchers ... have a significant impact on how patients respond to ... for mesothelioma. Surviving Mesothelioma has the full story. ... , Researchers at the University of Ljubljana and the ... pemetrexed for different types of polymorphisms. They found ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Anterior Cruciate ... year, but the type of material used to create ... in the game, say researchers presenting their work today ... of Sports Medicine ( AOSSM ). , ... population, allografts (tissue harvested from a donor) fail more ...
Breaking Medicine News(10 mins):Health News:Take Common Sense Steps to Stay Safe This Summer, from the July 2014 Harvard Men's Health Watch 2Health News:Take Common Sense Steps to Stay Safe This Summer, from the July 2014 Harvard Men's Health Watch 3Health News:Dental Implant Dentist, Kevin Sands DDS, Now Uses Mini and Full Mouth Implants to Replace Missing Teeth 2Health News:A Little Alcohol May Not Be Good for Your Heart After All 2Health News:New Research Finds Genetic Variables Impact Chemotherapy Response, According to Surviving Mesothelioma 2Health News:ACL Reconstructions May Last Longer With Autografts 2
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