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Tag: "debilitating" at biology news

Discovery of T-cell 'traffic control' boosts new drug promise

...tructive autoimmune process in patients with MS, a debilitating disease in which the body's T cells attack the myelin coating of nerve cells and disrupt their function. Neither Goetzl nor Rosen is involved in the on-going clinical trials of the new drugs and neither has financial ties to the companies that manufa...

Gifts from the sea

...s and clinicians to a better understanding of such debilitating human diseases as heart disease, stroke, cancer, Alzheimer's disease, and kidney disease. Horseshoe crab (Limulus polyphemus): The horseshoe crab's compound eye and the (easily accessible) optic nerve that connects the eye to the brain are both rela...

Purdue scientists may have found key to halting spinal cord damage

...njury, acrolein's hazard may be the key in causing debilitating paralysis that sets in after the initial trauma. "When a spinal cord ruptures, not only are the traumatized cells at increased risk of damage from free radicals that oxidize the tissue, but the cells also spill chemicals that actually help the free ...

Using nanoparticles, in vivo gene therapy activates brain stem cells

...logy and new therapies to address some of the most debilitating human diseases." Viral vectors for gene therapy always carry with them the potential to revert back to wild-type, and some human trials have even resulted in fatalities. As a result, new research focuses increasingly on non-viral vectors, which don...

Diabetic nerve therapy shows 'striking' results

...are no effective therapies available to treat this debilitating and frequent complication of diabetes and patients are generally prescribed painkillers to alleviate symptoms. "We are excited to be involved in testing this novel approach that may potentially have a dramatic therapeutic effect in populations of pa...

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

...the keys to developing promising new therapies for debilitating neurodegenerative diseases lies in our understanding of how new neurons are created and integrated into mature brain tissue," Zhou said. "This protein is an attractive drug target for either boosting neuron-forming processes or stem cell-based therap...

Researchers make headway in mystery of migraines

... a form of inherited migraine--the kind that cause debilitating headaches and light flashes known as auras--target a cellular process involved in brain cell communication. "A number of mutations have been shown to result in familial migraines," says Dr. Rhoda Blostein--a medical scientist at the Research Institu...

Disease progression model of pancreatic cancer developed by Penn researchers

...l likely open many new doors in understanding this debilitating disease. "With a model that can generate the full spectrum of disease, from preinvasive to invasive and metastastic lesions, we can begin to tease out the events that are linked to the progression of pancreatic cancer," explains Hingorani. "In trying...

Scientists discover how plants disarm the toxic effects of excessive sunlight

... radicals" - are thought to be at the root of many debilitating diseases. "There have been considerable advances in our understanding of how cells protect themselves from several reactive oxygen species," says Donohue. "However, nothing has previously been known about how cells alter gene expression to respond t...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...y that can help health professionals diagnose many debilitating diseases. This is particularly important for diseases like Alzheimer's where a reliable diagnostic tool is lacking and early intervention could have a significant impact on the lives of patients and their loved ones, in addition to lowering health ca...

A bacterial genome reveals new targets to combat infectious disease

... elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wolbachia bacte...

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