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Tag: "debilitating" at biology news

Human stem cell treatment restores motor function in paralyzed rats

...nsplanted neuronal cells. Current treatment for debilitating muscle spasticity is continuous systemic or spinal drug treatments using implanted pumps. These approaches, while effective to a degree, are often accompanied by side effects and eventual drug tolerance that lessens their efficacy. “These researc...

First clinical trial of gene therapy for childhood blindness

...y leading to an effective treatment for a rare but debilitating disease." ...

WHO data confirms low level of resistance to Tamiflu

... illness and is characterised by a sudden onset of debilitating clinical symptoms which affect the entire body. Up to 500 million people are infected by influenza and up to 500,000 deaths are attributed to influenza each year. Influenza complications occur in all patient groups and include bronchitis, sinusitis,...

DNA repair proteins monitored at double-strand break

...eleangiectasia, a disease that causes a variety of debilitating problems, such as neurodegeneration, cancer and sensitivity to irradiation leading to double-strand breaks that are not repaired," Kastan said. "And a lack of NBS1 causes Nijmegen breakage syndrome, another disease that leaves its victims at high ris...

Researchers develop marker that identifies energy-producing centers in nerve cells

...ce could unravel the mysteries of some of the most debilitating neurodegenerative diseases. The study's senior author, Tibor Kristian, Ph.D., an assistant professor in the Department of Anesthesiology at the University of Maryland School of Medicine, says there are animal models for several of these diseases incl...

Red flag for repetitive stress injuries identified for first time in humans

... someday lead to early detection and prevention of debilitating conditions such as carpal tunnel syndrome and tendonitis. The new study from Temple University senior researchers Ann Barr and Mary Barbe and their doctoral student, Stephen Carp, in the March issue of Clinical Science, found that the immune syste...

Enhancing activity of marijuana-like chemicals in brain helps treat

...als in the brain may point to a treatment for the debilitating condition of Parkinson's disease. In a study to be published in the Feb. 8 issue of Nature, researchers from the Stanford University School of Medicine report that endocannabinoids, naturally occurring chemicals found in the brain that are simila...

Bisexual fruit flies show new role for neurochemical

... the ability to concentrate, perceive and learn to debilitating illnesses such as amyotrophic lateral sclerosis, muscular dystrophy, post-traumatic stress syndrome and schizophrenia is influenced by the number of receptors on nerve cells. The more receptors each cell has at its communication points, or synapses, ...

Angelman syndrome deficits rescued in mice

...affects approximately one in 15,000 children, is a debilitating neurological disorder characterized by mental retardation, severely limited speech, and movement and balance problems. In 1997, researchers determined that Angelman syndrome was caused by a mutation in a single gene, called UBE3A. They subsequentl...

Scientists find new genes for Crohn's disease

...he focus of further research to understand how the debilitating inflammatory process is initiated and maintained in many cases of the disease. "As we collect more and more data from these genome-wide association studies, we continue to discover susceptibility genes for Crohn's and other inflammatory bowel diseas...

UCSF brain tumor vaccine trial shows promising results

...d to leave healthy tissue unaffected and limit the debilitating side effects typically associated with traditional cancer treatments such as chemotherapy and radiation therapy. Vitespen has been granted fast-track and orphan drug designations from the Food and Drug Administration for both metastatic melanoma (ski...

Protein sensor for fatty acid buildup in mitochondria

...upplements might help PKAN patients cope with this debilitating disease." "One of our challenges is how to develop an animal model of this disease that we can use to determine if reduced dietary fat and carnitine supplements offer hope in the treatment of PKAN in humans," said Suzanne Jackowski, Ph.D., a membe...

Cancer researchers add spice to research against rare neuromuscular disease

...discovered a compound that shows promise against a debilitating neurodegenerative condition known as Kennedy's disease, which is caused by a mutant gene. Currently there is no treatment for the inherited disorder, which resembles a slowly progressive form of Lou Gehrig's disease and affects only men. The compoun...

Susceptibility to Crohn's disease -- an important new clue

...iarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from the University of Liège, Belgium, have now uncovered an important clue to the susceptibility of individuals to this disease. In a genome-wide association study with more than 300,000 single nucleotide polymor...

Statin plus cancer drug deliver combo punch to brain cancer cells

...ma survive. "And those that do survive can suffer debilitating side effects caused by current toxic therapies." ...

Targeting tumors the natural way

...med at these receptors are always expected to have debilitating side effects. That's why Kiessling's approach holds such promise. "What we've shown is that you don't need a receptor that's found solely on tumor cells," she says. "You just need one that's found in significantly higher numbers on cancerous cells ...

Blocking immune cell action increases Alzheimer's-associated protein deposits

...w connection between immune cell function and this debilitating disease suggests potential new therapeutic strategies." While it has been known that the immune system reacts against amyloid-beta in the brain, the relation of that response to the pathology of Alzheimer's disease has not been clear. Within the...

Protein found that slows hepatitis C growth in liver cells

... virus less than 50 percent of the time and causes debilitating side effects. Those for whom that treatment fails are at high risk for fatal cirrhosis or liver cancer. In the United States, about half of all liver cancer cases occur in people infected by hepatitis C virus. The UTMB scientists reported their fi...

New test helps identify hepatitis C patients at high risk of developing cirrhosis

...ld be directed toward a long course of expensive, debilitating drug therapy, while low-risk patients might be better off delaying treatment. "Management of cirrhosis patients is challenging," said Ramsey Cheung, MD, associate professor of medicine at the school and chief of hepatology at the Palo Alto Vete...

Widely used hepatitis B drug spurs HIV drug resistance

... yet weakened their immune system and to avoid the debilitating side effects of anti-HIV medications. In the Hopkins study, researchers found in both laboratory and clinical tests that within six months of entecavir therapy, a so-called M184V mutation of HIV develops. Thio says viruses with this mutation ar...

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