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Tag: "database" at biology news

A new kind of mutation could explain numerous phenotypic variations in various species

...diseases. Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases. ...

Mobile DNA part of evolution's toolbox

...ved element to all the DNA sequences in the public database GenBank, the closest match was to DNA from the coelacanth -- an ancient fish thought to have gone extinct millions of years ago until a live specimen was caught in 1938 off the east coast of South Africa. The coelacanth is a descendant of the ancient...

Genetic 'roadmap' charts links between drugs and human disease

... a rank-ordered list of reference compounds in the database that have matching signatures. One of the surprising results to emerge from the Connectivity Map involves gedunin, a plant derivative that, despite a long history of medicinal use, is not well understood molecularly. The researchers identified gedu...

Solved: The mystery of flesh-eating bacteria's relentless attack

...to find an enzyme that degrades IL-8. Drawing on a database of enzymes and using advanced techniques that measure the levels of gene transcription products in a cell, they soon identified the culprit: an enzyme called ScpC. The team then created a mutant variation of the M14 strain of Streptococcus that co...

AIDS study challenges conventional treatment guidelines for HIV patients

... Network of Integrated Clinical Systems (CNICS), a database of real-time clinical care and laboratory data; b) the San Francisco Men's Health Study (SFMHS) and the Research in Access to Care for the Homeless Cohort (REACH). This cohort included approximately 12% female and 35% non- Caucasian participants. The...

PNAS study reveals why organs fail following massive trauma

... massive trauma. They then ran that list through a database of genetic information to see which of the genes changed by trauma were listed in the literature as having a role in T cell function. What emerged was a map of the likely functions of hundreds of genes and proteins related to T cell post-trauma dysfu...

Researchers barcode DNA of Venice museum's vast fungi collection

... and Arts. "We are building up a huge molecular database that will be available to the entire scientific co...ivity of forests and agricultural ecosystems, this database will greatly aid the diagnosis of plant diseases." Fungi are a kingdom of organisms that include ...

'Tribbles' protein implicated in common and aggressive form of leukemia

...he findings in mice were also validated in a large database of human cancer patients. In a survey of gene expression in AML patients, high Tribbles expression was found in a subset of patients who had been previously characterized by defects in C/EBPá. According to Keeshan, "C/EBPa defects have also been ...

Few clues about African ancestry to be found in mitochondrial DNA

...gues from other Universities in the USA analysed a database of the human variable region, or HVS-1 region, of ...HSV-1 sequences did not match any sequences in the database and fewer than 10% were an exact match to a sequence from a single African ethnic group. ...

Scientist's persistence sheds light on marine science riddle

When he started compiling an online database of seashells 15 years ago, Dr. Gary Rosenberg did ...ule to deep-sea animals using Rosenberg's detailed database of marine snails. They find a similar pattern: when species colonize the deep sea, large-bodied spec...

One signal elicits thousands of answers

... sites are now listed in the newly created Phosida database to make them available for efficient use by scient...heir results the research team created the Phosida database ( www.phosida.com ), where all the phosphorylation sites are listed with additional information and ...

RNA map provides first comprehensive understanding of alternative splicing

...ered. They took a bioinformatics approach, using a database of all alternatively spliced RNAs compiled by co-authors Terry Gaasterland and Bahar Taneri, to search for new genes that had clusters of Nova binding sites. Of the 50 or so transcripts with such clusters, 30 turned out to be alternatively spliced in...

'GreeneChip' -- New diagnostic tool that rapidly and accurately identifies multiple pathogens

...eatures include a comprehensive microbial sequence database that integrates previously distinct reserves of information about pathogens—for every entry of a pathogen and its properties, the GreeneChip contains a correlate of its genetic makeup. GreeneChip performance was initially tested by using samples...

By 2048 all current fish, seafood species projected to collapse

...isheries-related services. They used the fisheries database compiled by the United Nations Food and Agriculture Organization and the Sea Around Us Project at the Fisheries Centre, University of British Columbia. Finally, the scientists investigated how recovery of biodiversity in 48 marine protected areas -- ...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...ere turned on or off. The researchers then used a database generated by the Broad Institute that groups individual genes into common functional pathways to see where there were major differences. "We made a striking observation," says Sinclair. "Resveratrol opposed the effects of high caloric intake in 14...

'Hidden-hero' microbes in soil, water may help naturally clean toxic sites

...Kostka's FSU lab to develop and maintain a genetic database of genes of organisms that are present in the Oak Ridge site's subsurface. "With the genetic database and associated cutting-edge genomics techniques, my lab will determine and predict the functioning o...

Organic is healthier: Kiwis prove that green is good

...new research and running events, SCI has a growing database of member specialists who can give background information on a wide range of scientific issues. Originally established in 1881, SCI is a registered charity with members in over 70 countries. www.soci.org About Wiley John Wiley & Sons, Ltd...

2,000 influenza virus genomes now completed and publicly accessible

...the public through GenBank, an Internet-accessible database of genetic sequences maintained by the National Center for Biotechnology Information (NCBI) at NIH’s National Library of Medicine, another major contributor to the project. Seasonal influenza is a major public health concern in the United States...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

...access. USM will contribute its natural compound database for use in virtual screening for new inhibitors an...al repository for the project’s research data. The database will be distributed through the computational data grid, and accessible through web portals mirrored...

Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

...ompiled by others and created a publicly available database on the Web - PhosphoMotif Finder [ http://www.hpr...ational Academy of Sciences, while a report on the database appears in the March issue of Nature Biotechnology. Pandey’s team used electron transfer dissocia...

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