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Tag: "damaged" at biology news

New drug could reduce tissue damage after heart attack

...ity, and CRP is always deposited in and around the damaged heart tissue. Inflammation contributes significantly to the extent of heart attack damage and this can be exacerbated by CRP. The UCL team has previously shown that human CRP increases the severity of damage in experimental models of heart attack ...

'Bad' enzymes may wear white hats after stroke

...used by a clot or burst blood vessel--MMPs chew up damaged brain tissue. This increases the risk of swelling ...ts following stroke. They found the enzymes in the damaged areas at one and three days after the stroke. However, seven to 14 days after the stroke, high level...

New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

...that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome ...f the transplanted cells had incorporated into the damaged regions of the kidney glomeruli in the knockout mouse, emerging as healthy renal cells (podocytes an...

A surprising pair of proteins help make healthy eggs

...is well-studied protein is found at high levels in damaged nerve tissue as well as in the tumors of certain cancers, including cancer of the skin and liver and in Hodgkin's lymphoma. The new research is the first to connect c-Jun to this network of ovarian genes. Freiman said the discovery reveals a potentia...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

...hey didn't know its role. DNA is easily and often damaged by environmental and chemical sources such as ultraviolet radiation, cigarette smoke, and other natural and artificial toxins. These create injury sites or lesions. In healthy situations, DNA repair signal pathways are competently monitoring for dama...

Novel molecular 'signature' marks DNA of embryonic stem cells

...so limited in their abilities to repair or replace damaged cells. "This is an entirely new and unexpected discovery," said Brad Bernstein, lead author of the study, assistant professor at Massachusetts General Hospital and Harvard Medical School, and a researcher in the Chemical Biology program at the Broad...

Stem cell study for patients with heart attack damage seeks to regenerate heart muscle

...hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart...muscle being cut off during the heart attack. The damaged muscle inhibits the heart's overall ability to pump blood, leading to heart failure," said Rush prin...

NJIT engineer poised to take stem cell research a step forward

...stem cells can soon be used to treat patients with damaged cartilage. Arinzeh and Jaffe are collaborating on this project with Louis Rizio, MD, an orthopedic surgeon and sports doctor at Mountainside Hospital, Montclair/Glen Ridge. Rizio, who specializes in cartilage repair and arthroscopic surgery, will d...

Expedition discovers marine treasures

...ged atoll. The fragile ecosystems of Saba Bank get damaged by anchors and chains of ships that wait at the atoll to avoid anchoring fees in territorial waters of St. Eustatius. The large ships also endanger local fishermen of Saba in their small boats, forcing them away from traditional fishing grounds and ...

New possibilities to fight pests with biological means

...released by the plant and attract wasps toward the damaged corn plant. Since this mechanism is based only on ...t of nine scent compounds that was released by the damaged corn plant. To demonstrate that TPS10 is indeed the important gene, the scientists introduced TPS10 ...

Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal

...ely fight off any outflow of toxic substances from damaged nerve tissues. In the present study, the scientists showed that the same immune cells may also be key players in the body's maintenance of the normal healthy brain. Their findings led them to suspect that the primary role of the immune system's T c...

Researchers reveal lung's unique innate immune system

...ment of the alveola is a delicate one, it would be damaged if the macrophage immune system was in a constant battle-ready status," said Raz. "This could readily lead to the type of inflammation we see in autoimmune diseases of the lung such as asthma." Therefore, the alveola possess a complex immune system...

Common enzyme is a key player in DNA repair

...t and accurate replication of a particular kind of damaged DNA, reports Graham Walker, an HHMI professor at t...ise and replace a faulty section. But sometimes a damaged bit of DNA slips through unrepaired. A faulty nucleotide--the basic constituent of DNA--can stall th...

Removing DNA repair gene causes metabolic syndrome

Removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome,... of a pathway of enzymes involved in repairing DNA damaged by free radicals that trigger oxidative stress on cell molecules. As a consequence of these studies,...

Potential heart benefit found in stem cells

... the corresponding capillaries in four areas: the damaged or infarct area, the healthy myocardium (cardiac muscle), and in two parts of the border zone. As predicted, the infarct areas of the heart walls in the ADSC group were thicker than in the animals not receiving the injection (5.9 vs. 3.6 millimete...

'Genetic network' guards against lethal DNA damage

...nd cell cycle progression by "checkpoints" so that damaged DNA can undergo repair, and responses to oxidative stress necessary for reducing the intracellular levels of highly reactive molecules that bind to and damage DNA. The yeast has about 6,000 genes, of which about 1,000 are essential to survival and 5...

Study shows that cells have a natural defense against HIV

...ir chromosomes. Both proteins help the cell repair damaged DNA. Yoder, Fishel and their collaborators then introduced mutations into the genes for the two proteins, which crippled the proteins' ability to repair DNA. When cells with these mutations were then infected with HIV, they showed higher levels of ...

Bone and cartilage growth to blame for heart valve disease

...only option is to surgically repair or replace the damaged valves. Our findings open the door to the idea th...rgeries in the U.S. each year to repair or replace damaged valves. Mitral valve disease is a leading cause of atrial fibrillation, which is a major culprit in...

Blood flow in brain takes a twist, affecting views of Alzheimer's

...e, perhaps it's the astrocytes themselves that are damaged first," she said. "It may be that for whatever reason, astrocytes are not doing their job properly, and then blood flow decreases. This could lead to the death of the neurons, which would starve from a lack of nutrients, since the neurons depend on t...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...l expression of SCF and by normal neurons that are damaged by the growing tumor. The researchers point out that the clinical significance of these findings extends beyond identification of SCF as a rational target for gliomas. "Normal neuronal expression of SCF in response to traumatic brain injury also rais...

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