damaged 2 2

Tag: "damaged" at biology news

Heart repair gets new muscle

...d into mice with heart damage, they migrate to the damaged tissue and differentiate into cardiac muscle cells. Epstein and colleagues argue that Spoc cells are more likely to be precursors to cardiomyocytes than to be some other type of skeletal muscle stem cell. This is based on an absence of protein marke...

Newly discovered pathway might help in design of cancer drugs

...What we did was to identify a way to create a very damaged form of DNA that is often more deadly to the cell ...on, with one exception: Greenberg's team's DNA was damaged at only one place on its chain, allowing the researchers to study it and learn about that particular...

New understanding of DNA repair may pave way to cancer treatments

...rks is to halt the cell's cycle to allow repair of damaged DNA before such damage becomes permanent." Ronai and his colleagues are now determining how molecules like ATF2 can balance their dual roles. "High doses of radiation, as well as changes that take place in cancer and pathologic situations, can activ...

Cerebral navigation: How do nerve fibers know what direction to grow in?

...nhibition. Such intervention could possibly enable damaged axons to regenerate (normally impossible in a mature nervous system) and ultimately restore nerve function. It's been known that cells synthesize an inhibitory protein called ephrin, which binds to a receptor called Eph on the axon's growth cone. Bu...

Duke engineers develop new 3-D cardiac imaging probe

...ment devices such as ablation probes that burn off damaged cells that cause an irregular heart beat. Clinicians must repeatedly and painstakingly reposition the 2-D probe during treatments so, instead, they use fluoroscopy (X-ray movies) to guide the placement of the treatment devices. However, the use of X-...

Protein helps regulate the genes of embryonic stem cells

...uld be derived from stem cells and used to replace damaged or diseased tissue. Magnuson and his colleagues chose to study how eed influences genes in embryonic stem cells because they thought that would be directly applicable to stem cell technologies. "In order to get a handle on individual stem cell ther...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

...hydrogen atoms) on a cytosine base adjacent to the damaged site. Without this methyl group, the bulky chemical carcinogen resides at an external binding site in the minor groove of the DNA double helix. However, in the presence of this single methyl group, it assumes an intercalated structure in which the ca...

Genetic therapy reverses nervous system damage in animal model of inherited human disease

...uring this particular time led to a restoration of damaged neurons, even though the lesions that represent the disease were already extensive." According to Charles H. Vite, the lead author of the paper and an assistant professor of veterinary neurology at Penn, the treated cats not only demonstrated dramat...

Unchecked DNA replication drives earliest steps toward cancer

...ads to dangerous later-stage cancers with multiple damaged genes. In a new study, researchers at The Wistar Institute answer this vital question and suggest why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in so many different cancers. Mutations in p53 are found in the ...

Scientists generate patient-specific stem cells, Science study says

...lanting healthy cells into humans to replace cells damaged by diseases such as Parkinson's and diabetes. Each of the 11 new human embryonic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nucleus had be...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...lanting healthy cells into humans to replace cells damaged by diseases such as Parkinson's and diabetes. Each of the 11 new human embryonic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nucleus had be...

Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves

...row when their axons are damaged. But how does the damaged axon inform the cell body that it must start producing vital proteins for the healing? That's precisely where the molecular messengers, proteins called Erk-1 and Erk-2, enter the picture. When the axon is injured, these proteins bind to molecules of ...

WHO suspends Marburg work, appeals for new funds

...erations yesterday when vehicles were attacked and damaged by local residents. As the situation has not improved, no surveillance teams were operational today in this province, which remains the epicentre of the outbreak. WHO staff in Uige were notified today of several fatalities but teams were unable to i...

Young Blood Revives Aging Muscles, Stanford Researchers Find

... lie dormant but come to the rescue in response to damaged muscle-at least they do in young mice and humans. In older mice the satellite cells hold the same position, but are deaf to the muscle's cry for help. In the Nature study, Rando and his group first attached old mice to their younger lab-mates in a w...

Natural Killers Could Lead to New Hepatitis Treatments

...m assault on marauding microbes, other invaders or damaged tissue. The findings offer a new way of thinking about this important class of immune cell, which is responsible for the inflammation and cell death in the liver due to hepatitis. Hepatitis can be a reaction to viruses, parasites such as malaria or ...

Researchers pioneer new gene therapy technique using natural repair process

...en DNA strands of one chromosome break, creating a damaged section. Cells have two copies of nearly every chromosome (one each from the mother and father) and they must duplicate these during cell division so that the subsequent cells will also have two each. The wounded chromosome takes advantage of the hea...

Tsunami-damaged coral reefs should be left to recover naturally, say scientists

Coral reefs damaged in the Asian tsunami tragedy should be allowed to ...s will need to examine requirements for rebuilding damaged sectors such as fisheries and tourism, and rehabilitating the natural systems on which they depend, ...

U of T researchers map role of Epstein-Barr virus in cancer

...n response to certain problems in the cell such as damaged DNA and this stops the cell from proliferating. Through binding USP7, EBNA1 keeps the p53 levels low so cells will continue to divide when they shouldn't, which means they're now more likely to develop into cancer," Frappier says. "All viruses known...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...olecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppr...e cell to commit suicide, permanently removing the damaged DNA from the organism. Since the p53 protein is able to trigger such drastic action as cellular sui...

Stem cell treatment improves mobility after spinal cord injury

...formed as the oligodendrocyte cells wrapped around damaged neurons in the spinal cord. Within two months, these rats began to show significant improvements in walking ability in comparison to injured rats who received no treatment. In the rats with 10-month-old injuries, though, motor skills did not return....

1 2 3 4 5 6 7 8 9 10