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Tag: "damaged" at biology news

Novel regulatory mechanism identified for key tumor suppressor p53

...ng to DNA to activate genes that direct cells with damaged DNA to cease dividing until the damage can be repa...epairs cannot be made, p53 commands the cells with damaged DNA to self-destruct so they are no longer a danger to the body. This powerful ability of the p53 ...

Most important actors in the growth process of neurons identified

...therapies for diseases that are the consequence of damaged or diseased neurons. The fruit fly as model Bassem Hassan is using the fruit fly (Drosophila melanogaster) as model for his research. Many processes in this small fly are in fact comparable to processes in humans, even for something as complex as ...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...t 10 million people worldwide who are blind due to damaged or diseased corneas or many millions more who are ... into the eye as replacements for inner-eye lenses damaged by cataracts. The researchers have filed four patents for ocular applications of the hydrogel. ...

Mayo discovers protein as potential tactic to prevent tumors

...l division also directs cell death for those cells damaged during duplication. This knowledge represents a po... in the cellular mechanism that leads to repair of damaged DNA." If cells pass this quality control checkpoint, they can resume the process of dividing into...

Regulating the nuclear architecture of the cell

...division checkpoints slow down the cell cycle when damaged DNA is detected, and DNA repair mechanisms move in to fix the damage." However, if these replication checkpoints are crippled in flies that also have mutations in the H3K9 methylation and RNAi pathways, Karpen says, genome aberrations accumulate "and...

Artificial cornea offers better results for infants, some blind patients

...nfants and adults who are blind due to a cloudy or damaged cornea are seeing some remarkable results thanks t...neas, or congenital causes like glaucoma that have damaged the cornea. Aquavella said the advent of a trouble-free artificial cornea or K-Pro is good news for ...

MIT material stops bleeding in seconds

...hemostasis, the process of halting bleeding from a damaged blood vessel. Doctors currently have few effective methods to stop bleeding without causing other damage. More than 57 million Americans undergo nonelective surgery each year, and as much as 50 percent of surgical time is spent working to control b...

Rescuing injured hearts by enhancing regeneration

...October 9). Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead repla... is to inject smaller doses of the agents into the damaged area of the heart in gel form, or instill them through a catheter, so that they would remain in the ...

A new approach to growing heart muscle

...oser to the goal of creating replacement parts for damaged human hearts, or eventually growing an entirely new heart from just a spoonful of loose heart cells. This week, University of Michigan researchers are reporting significant progress in growing bioengineered heart muscle, or BEHM, with organized cell...

First Quantum Grant to fund stem cell repair of damage from stroke

...ir international research initiative to regenerate damaged brain cells and blood vessels for the treatment of...own blood supply to allow it to be placed into the damaged brains of stroke patients where it will provide a source of neural and vascular cells that will cont...

Natural protein stops deadly human brain cancer in mice

...s, which, instead of triggering the replacement of damaged cells, form cancer tissue. Stem cells, unlike all other cells in the body, are capable of forming almost any kind of cell when the right "signals" trigger their development. For their treatment experiment, the researchers relied on a class of pro...

Environmental toxins may cause body's defenses to worsen lung disease

...the immune system immediately wants to destroy the damaged cells so healthy tissue can take over," explains B...ures--it may cause the immune system to attack the damaged tissue in the same way it would if the tissue were infected with bacteria or a virus. "The same si...

Newts which regrow their hearts

...contribute to new cell therapies for patients with damaged organs (Journal of Cell Science, 2006). The red-s...articular reason: whereas humans cannot regenerate damaged heart muscle adequately after a heart attack and the destroyed muscle tissue scars over instead, fol...

Scientists show drug can counteract muscular dystrophy in mice

... for the first time that a single drug can rebuild damaged muscle in two strains of mice that develop diseases comparable to two human forms of muscular dystrophy. This advance, which is reported online in Nature Medicine, is the latest from a research collaboration that began several years ago by the teams ...

Diabetes slows nerve recovery after heart transplant

...e heart's ability to develop new nerves to replace damaged ones--is slower in diabetic patients," said Frank M. Bengel, a visiting associate professor of radiology and the director of cardiovascular nuclear medicine at Johns Hopkins Medicine's Russell H. Morgan Department of Radiology and Radiological Scienc...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

... proof of principle that our approach to repairing damaged retina by transplantation of appropriate cells can be successful." Swaroop sees several next steps in his quest to find treatments for retinal and macular degeneration. His research team will continue to study the properties of photoreceptor cell...

Heart smart: new drug improves blood flow

...ug ?developed by Bayer HealthCare ?reactivates the damaged enzyme. "Our results show that the drug directly binds to and repairs the damaged enzyme. And as the number of free radicals increases, the drug starts working harder," says Dr. Schm...

Researchers seek to design first treatment for neuroAIDS

...poptosis), a normally healthy process where old or damaged cells chose to die and be recycled. Furthermore, nerve cells exposed to HIV may lose their ability to pass on nerve signals long before the virus causes them to self-destruct. To protect themselves from infection, exposed nerve cells pull in their br...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

... when the enzyme encounters an impediment, such as damaged DNA. Kornberg’s group captured the first picture of the polymerase II transcribing complex by X-ray crystallography in 2001. Those structures revealed the complex with a nucleotide still in the enzyme’s addition site, just after it had been added t...

Lungs try to repair damaged elastic fibers

...ructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contradicts the conventional wisdom on the capabilities of the adult lung. The study "Evidence for attempted regional elastic fiber repair in severe emphysema," was done by Jason Woods, Kristin Castillo, Alexander ...

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