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Tag: "cytokines" at biology news

Blood test may help signal tumor's remission, return in throat cancer patients

...n head and neck cancer patients. These include two cytokines known as Interleukin (IL)-6 and IL-8, and three gr... (VEGF), and hepatocyte growth factor (HGF). These cytokines and growth factors play an important role in the body’s inflammatory response and in the growth of c...

Researchers develop buckyballs to fight allergy

...stances such as histamine, heparin and a number of cytokines are rapidly released into the tissues and blood, promoting an allergic response. The researchers found that the unique structure of the buckyball enables it to bind to free radicals dramatically better than any anti-oxidant currently available, su...

Molecule that destroys bone also protects it, new research shows

...se the consequences of therapies that target these cytokines need to be understood." ...

Researchers create mouse lacking key inflammation gene

...des for the LITAF protein. They found that several cytokines were induced at lower levels in the LITAF-deficient mice compared with the levels observed in the LITAF-positive control mice. Specifically, the deficient mice were more resistant to LPS-induced lethality. "The generation of the macrophage-specifi...

Resistance and genetic sensitivity to sleeping sickness

...he disease. Depending on their position on certain cytokines genes, the mutations investigated were shown to be capable of inducing in the subject carrying them an increased risk of developing this human trypanosomiasis, or conversely a higher chance of a protector effect (2). The associations brought out b...

Leptin found to control appetite and limb development in frogs

...is known to be part of a family of proteins called cytokines that includes pituitary growth hormone, and it has been found to increase cell proliferation in the brains of rats. Leptin is also found in late-stage fetal humans, mice, and sheep, and appears to be linked to birth weight, but little is known abou...

Research reveals inner workings of immune system 'thermostat'

...y George Yap of Brown University, shows that these cytokines don't operate independently and in opposition. The..., the same protein that signals "hot" inflammatory cytokines Interleukin 12 and Interferon-α and Interferon-β. "Under the prevailing paradigm, scientists belie...

Montreal researchers identify defects of immune cells

...howed extensive perturbations in the production of cytokines required for protection against oral candidiasis in the transgenic mice. "These findings regarding the specific immune defects which trigger candidiasis are very promising," explains Dr. de Repentigny. "This new knowledge will be instrumental in des...

Research reveals control of potent immune regulator

...esearch Institute, found that the pro-inflammatory cytokines not only cause NK cells to make IFNg, but they als... which inhibits production of IFNg. That is, the cytokines not only increase some positive regulators of IFNg production, but they also shut down the TGFb sign...

Mice lacking key immune component still control chronic viral infections

...ng the part or emit inflammatory hormones known as cytokines that trigger other immune defense measures. Because the genetically modified mice used in their experiment lacked the genes that contain instructions for making MHC Class I molecules, Virgin and his colleagues expected to see little response from C...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

... engineered neural stem cells to transport several cytokines ?proteins that regulate immune responses ?to track... in an immune response to tumor cells. The earlier cytokines produced good results, but IL-23 is even more potent," Yu said. "Most anti-tumor gene strategies at...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...ully looking at some genes related to inflammatory cytokines and we'll see how individual response to inflammatory stimuli may increase or decrease a person's risk of developing a brain tumor," Scheurer said. Influence of Chronic Inflammation on Prostate Carcinogenesis: A Five-Year Follow-up Study: Abstract ...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

.... "It is possible that for most of human history, cytokines like IL-25 have promoted type 2 T helper cells that fight infection with intestinal parasites like Trichuris, " said Colby Zaph, a co-author and Irvington Research Fellow at Penn. "In industrialized countries, where worm infections are now rare, thi...

Protein finding could lead to treatment for inflammatory diseases

...biology, treated human embryonic kidney cells with cytokines known to activate NF-kB. Cytokines are chemicals m... activation in MCV-infected skin cells, to prevent cytokines from boosting the immune system. MC160 is probably helping the virus persist." Upon further examina...

Lack of a key enzyme dramatically increases resistance to sepsis

... most likely due to an initial hyper-production of cytokines that fight the infection. "The resulting beneficial effect of cytokine hyper-production runs contrary to some of the current thinking in sepsis research," Ulevitch said. "The general thinking is that this initial cytokine 'storm' is harmful, and t...

New compound stops brain cell degeneration in Alzheimer's disease

...its production of pro-inflammatory proteins called cytokines by glia, important cells of the central nervous sy...proof of concept that targeting over-production of cytokines by activated glia is a viable approach that has the potential to modulate disease onset and progress...

Boosting newborns' immune responses

... production of "danger signals" ?proteins known as cytokines that trigger other immune cells to mount a defense...the cells produced normal, adult levels of two key cytokines ?TNF-alpha and IL-12 ?and another immune-system stimulant, CD40. "These findings suggest that agen...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

...ining of joints where they release proteins called cytokines that modulate communication between the immune cells and synovial cells, the cells that line the joint. As the researchers discovered in earlier animal studies, synovial cells have a receptor on their surface that's a perfect fit for a particular cyt...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...renal cells, robust suppression of proinflammatory cytokines in the ARF kidney and upregulation of anti-inflamm... the delivery of renoprotective growth factors and cytokines to the sites where kidney cells are primarily destroyed from both the blood and urinary aspects of t...

Climate model links higher temperatures to prehistoric extinction

...stances such as histamine, heparin and a number of cytokines are rapidly released into the tissues and blood, promoting an allergic reaction. Mast cells are believed to be generated by different precursor cells in the bone marrow. In the in vitro portion of the study, researchers used mouse bone marrow cell...

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