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Tag: "cytokine" at biology news

U of M researcher examines newly emerging deadly disease

...drome seen in these patients resulted from massive cytokine release induced by the S. aureus strains. ...

How an AIDS-Related Cancer Unleashes Inflammation

...oma-associated herpesvirus that causes KS initiate cytokine production? "While there are many genes in the viral genome that are capable of inducing cytokine production, the mechanism underlying this induction has remained unknown," said Ganem. In their stu...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...d remember, possibly via some link (says Bilbo) to cytokine IL-1BETA production. ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...ases. For example, the expression of inflammatory cytokine proteins by immune system cells must be finely tuned so that these proteins do not cause more damage to the body than the bacterial infection they were produced to defeat. Excessive inflammation can lead to organ failure and death, and this is exactl...

Natural Killers Could Lead to New Hepatitis Treatments

...ld stop in the vicinity of that signal and provide cytokine signals that would attract other inflammatory cells that destroy the invading microorganism and may also facilitate repair of the damage.?/p> In other experiments, the researchers explored the role of the CXCR6 receptor in the NKT cell's behavior...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

... 23, researchers demonstrated the means by which a cytokine called interferon gamma (IFNγ induces death of developing mast cells in a mouse model system. Although IFNγ induced cell death in developing mast cells, it did not affect the survival of mast cells that had already undergone differentiation...

Climate model links higher temperatures to prehistoric extinction

... 23, researchers demonstrated the means by which a cytokine called interferon gamma (IFNγ induces death of developing mast cells in a mouse model system. Although IFNγ induced cell death in developing mast cells, it did not affect the survival of mast cells that had already undergone differentiation...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...diated by their antiapoptotic, mitogenic and other cytokine actions," the paper said. "Specifically, these as yet incompletely defined paracrine actions of MSC result in the renal downregulation of proinflammatory cytokines IL-1-beta, TNF-alpha, and IFN-gamma, as well as iNOS (inducible nitric oxide synthase...

Stress substantially slows human body's ability to heal

...ples showed differences as well. The levels of one cytokine ?interleukin-6 (IL-6) ?increased one-and-a-half ti...ur long-held contention that even small changes in cytokine levels will have a marked effect on health." William Malarkey, professor of internal medicine; Sta...

Boosting newborns' immune responses

...week of life, their white cells' production of the cytokine IL-6, which inhibits parts of the immune response, is greater than that in adults. A third study, to be published in the Journal of Immunology, finds that newborns' cord blood also has high levels of adenosine, providing an explanation for newborns...

Lack of a key enzyme dramatically increases resistance to sepsis

... infection. "The resulting beneficial effect of cytokine hyper-production runs contrary to some of the curr...h said. "The general thinking is that this initial cytokine 'storm' is harmful, and that belief has been the basis of a number of unsuccessful clinical studies....

Protein finding could lead to treatment for inflammatory diseases

...tic tool. Painful inflammatory responses caused by cytokine production in rheumatoid arthritis, Crohn's disease and similar maladies potentially could be cured by MC160. It is hoped, she said, that the protein's large size (almost 60 kiloDaltons) can be reduced to smaller, activity-specific peptide regions. ...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

...thritis and MS." IL-25 can be considered a "good" cytokine by limiting chronic inflammatory responses. At the same time, the ability of IL-25 to promote type 2 responses that drive asthma could be considered the "evil" side of the cytokine. By examining mice infected with Trichuris, a species of intestinal...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

Attaching a recently discovered cytokine to neural stem cells derived from bone marrow, res...t also includes the first report on the use of the cytokine interleukin-23 (IL-23) as a potential gene-delivered therapy against glioma. "The paper recapitulat...

Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent

...pursue is the modulation and change in Th1 and Th2 cytokine and inflammatory immune responses to the anticipation and experience of the positive mood state changes associated with mirthful laughter." Future research in this area with more subjects "needs to elaborate these findings in psychoneuroimmunology u...

Johns Hopkins lab scientists tame overactive CF protein

...nterference also staved off inflammation caused by cytokine IL8, which is the main inflammatory chemical produced by CF damaged cells. "Targeting VCP, we were able to achieve two things at once -- restoring chloride channel function and curbing inflammation" says co-author Neeraj Vij, Ph.D., a postdoctoral f...

Selectively blocking inflammatory signals may protect mice from MS

...hey also introduced a gene (known as suppressor of cytokine signaling 1, or SOCS1) that blocked the response of myelin-producing cells to interferon-gamma. Although transgenic mice with low levels of interferon-gamma showed no symptoms of nervous system damage, 18 out of 20 mice exposed to higher interferon ...

Inflammation markers identify fatigue in breast cancer survivors

...e-floating receptors can still bind to circulating cytokine IL-6, Dr. Irwin noted, and in that form have the potential to interact with cells that normally don't respond to cytokine/receptor activation ?such as brain cells that may regulate fatigue sensation. IL6 is a biological chemical that helps drive in...

Parasite infection may benefit MS patients

... known as cytokines, the number of cells producing cytokine suppressants was measured and found to be significantly higher in infected patients. The authors suggest that their findings provide evidence to support that an autoimmune response as a result of parasite infection can result in a decrease in the ...

Mechanisms involved with tumor relapse identified

...cancer, researchers found that interferon gamma, a cytokine or chemical messenger that is produced by cells of the immune system upon activation, plays a role in tumor relapse. In humans, interferon gamma is also produced by white blood cells of the immune system in response to invasion by pathogens or tumors...

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