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Tag: "cystic" at biology news

Researchers discover 'acquired' DNA key to certain bacterial infection

...fection in patients with chronic lung diseases and cystic fibrosis is increasing. Understanding the mechanism by how M. avium penetrates the macrophage and infects humans may eventually lead to interventions that can prevent, or at least, reduce the chance of infections, though Bermudez cautioned that it...

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

...as high blood pressure, diabetes, atherosclerosis, cystic fibrosis and neurodegenerative conditions, as well as in aging, may interfere with the G-protein coupled receptor signaling." ...

Type of stem cell found to reside in transplanted lungs

...us diseases and conditions, such as heart disease, cystic fibrosis, graft-versus-host disease, muscular dystrophy, and as a possible source for improved recovery of cancer patients undergoing chemotherapy. Lama’s laboratory currently is working on another study involving the lung-derived MSCs that shows...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...op a form of ductal adenocarcinoma associated with cystic lesions that can be detected earlier, is less aggr... and has a 50 percent long-term survival rate. Why cystic ductal pancreatic cancer behaves differently, despite carrying the same basic genetic mutations as t...

Technology reveals 'lock and key' proteins behind diseases

...hemical processes responsible for diseases such as cystic fibrosis and could one day pave the way for pharma...r (CFTR), which, when disabled by mutation, causes cystic fibrosis, a hereditary disease that results in progressive disability and early death. Another impor...

New study may show how to forestall a fatal, virus-caused immune-system meltdown

...scovered by people studying endocrinology, cancer, cystic fibrosis and so on ?we find that things suddenly begin to make sense,?said UTMB professor Norbert Herzog, one of the paper’s senior authors. “Cell signaling networks are like spider webs—pulling on one strand causes all the strands to move, and the I...

Trojan horse strategy defeats drug-resistant bacteria

...on medical devices and in the lungs of people with cystic fibrosis. For these reasons, a great deal of resea...ive against strains of Pseudomonas aeruginosa from cystic fibrosis patients that were resistant to multiple antibiotics. In mice, gallium treatment blocked bo...

Gallium: A new antibacterial agent?

...s of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aeruginonsa forming...sa, a major cause of infection in individuals with cystic fibrosis and of infection acquired in hospital. ...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

... further shuts down a protein that is defective in cystic fibrosis patients. The disruption to this protein ...peutic target for treating lung infections in some cystic fibrosis (CF) patients. Lung infection, facilitated by CF mutations, is the main cause of death i...

Key found to kill cystic fibrosis superbug

... from Edinburgh, have discovered a way to kill the cystic fibrosis superbug, Burkholderia cenocepacia. These...in healthy people, it can be fatal for people with cystic fibrosis (CF), an inherited disease where the lungs become clogged with thick mucus, often leading t...

Brain tissue reveals possible genetic trigger for schizophrenia

... genetic diseases, such as Huntington's disease or cystic fibrosis, the basis is a gene mutation that leads to a malformed protein. But with other complex genetic disorders ?such as schizophrenia, many cancers, and diabetes ?we find not mutated proteins, but correctly formed proteins in incorrect amounts," ...

Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positi...

U of MN researchers turn cord blood into lung cells

... blood from babies who have lung diseases, such as cystic fibrosis, to do more research to understand how these diseases evolve as well as to develop better medical treatments," said David McKenna, M.D., assistant professor of lab medicine and pathology and medical director of the Clinical Cell Therapy Lab ...

Proteins may predict lung transplant rejection

...ses such as chronic obstructive pulmonary disease, cystic fibrosis, pulmonary hypertension, idiopathic pulmonary fibrosis and other diseases. Patients who receive a new lung may suffer bouts of acute or chronic rejection. Acute rejection often responds to therapy. Chronic rejection, which results in scar...

Environmental toxins may cause body's defenses to worsen lung disease

... findings may also have applications in asthma and cystic fibrosis as well as other chronic lung diseases. The overall goal of the study is to expand existing scientific knowledge of how epithelial cells in the lungs communicate with the immune system in response to environmental and occupational pollutant...

Discovery could aid fight against cystic fibrosis infection

... be surviving in the lungs of chronically infected cystic fibrosis (CF) patients. "This work is important...ed immune system, a burn patient, or a person with cystic fibrosis (CF)." Pseudomonas aeruginosa (PA), a pathogen that infects more than 80 percent of cyst...

Study reveals how cells destroy faulty proteins in cystic fibrosis

...ystem that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of...gene that produces a misshapen form of the protein cystic fibrosis transmembrane conductance regulator (CFTR). People with cystic fibrosis do not have enough ...

DNA: Bacteria's survival ration

...mful bacteria. One of the pathogens implicated in cystic fibrosis is suspected of feeding on DNA in lung tissue, Finkel said. Biofilms, which have been linked to chronic infections, also may harbor nutritionally competent germs. If researchers succeeded in turning off nutritional competence in such pathog...

Johns Hopkins lab scientists tame overactive CF protein

...med an overactive protein that plays a key role in cystic fibrosis (CF), a genetic disorder that interferes with the body's ability to transport chloride in and out of cells. Using a tool called RNA interference on cells in the laboratory, researchers successfully intercepted signals sent out by the rampa...

Bone marrow cells can become functional gut lining cells

...ss functional chloride channels (known as CFTR, or cystic fibrosis transmembrane conductance regulator) whic...urrently far too low to be used as a treatment for cystic fibrosis, an inherited disease in which the organs, especially those of the pancreas, lungs, and int...

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