Tool developed to silence genes in specific tissues using RNAi
...nery that destroys the invading RNA. This involves cutting up the double-stranded RNA, separating it into single strands, and destroying other single-stranded RNA molecules that are complementary to those small RNA segments. Scientists quickly realized that if they could produce a double-stranded RNA that m...Next good dinosaur news likely to come from small packages
...ancement of Science annual meeting Friday explores cutting edge technology used to divine new information from ancient bits of bone and tissue. One of the field's hottest topics is whether proteins and DNA survive the test of time. Ostrom is putting her bet on proteins and is working with an international...How does the brain know what the right hand is doing?
...o. The researchers inflated a cuff around the arm, cutting off blood flow and temporarily paralysing and anaesthetising the arm. They then repeated the tests. Before the cuff was inflated, the subjects accurately indicated where their hand was pointing, both when they were resting and when they were pushing...UCLA scientists find male gene in brain area targeted by Parkinson's
...Y triggered Parkinson's symptoms in the male rats, cutting their physical agility by half in a week. "Initially, the rat could walk 14 steps in 10 seconds," he noted. "After we lowered the SRY levels in its brain, the rat could only manage seven steps in the same amount of time." Vilain believes that varia...Superconducting magnet attracts molecular research
... for decades, and this magnet helps keep us at the cutting edge of research," said Pochapsky. "It's an investment in the future." ...New, unique microscope for nanotech
...tructures tagged with fluorescent dyes. Instead of cutting a sample into thin slices, a researcher can focus through the entire sample and resolve it in three dimensions. The atomic force microscope uses an extremely fine tip to run over the surface of a sample and "see" extremely fine detail down to an ato...Twin molecular scissors link creation of microRNAs with gene-silencing
...icer and TRBP then hand over the messenger RNA for cutting by Argonaute 2. Still holding the guide miRNA, RIS...nal copies of its target messenger RNA to cut. The cutting destroys the messenger RNA, effectively silencing the gene from which it was transcribed. "The two ...RNA splicing occurs in nerve-cell dendrites
...trons (non-coding regions). mRNA splicing works by cutting out introns and merging together the remaining exon pieces, resulting in an mRNA capable of being translated into a specific protein. The vast array of proteins within the human body arises in part from the many ways that mRNAs can be spliced and ...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
...ed the formation of new blood vessels, effectively cutting off the supply of nutrients to the malignant cells. This effect was seen in both the test tube and animal experiments. This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic cancer, and represents a...Gene therapy potential for treatment of pancreatic cancer
...ed the formation of new blood vessels, effectively cutting off the supply of nutrients to the malignant cells. This effect was seen in both the test tube and animal experiments. This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic cancer, and represents a...New study expands understanding of the role of RNA editing in gene control
...g a key miRNA processing enzyme called Drosha from cutting the precursor miRNA molecule at a critical step in that process. Looking downstream along the miRNA processing pathway, the scientists also discovered that a molecular complex called RISC played a surprising role. Several components of RISC are know...Emerald Spectre haunts Ontario's ash forests
...e one day in the summer of 2003 to see a neighbour cutting down 25 ash trees, among the borer's first victims. In Michigan's Wayne County, the first area infected, 60 per cent of the ash trees are already dead. "In my opinion, the prognosis does not look good in the Great Lakes region," says Dr. MacIsaac. ...Scientists discover genetic pathway responsible for breast cancer cell growth
...gene discovery per year," says Dr. Giguère. "Using cutting edge new technology derived directly from the human genome project, this study adds over hundred additional genes to this total." The technology used information obtained from the human genome project to create a new type of DNA microchip containing...World-first technology enables study of ancient bacteria
...ve built an isolation system, as well as a special cutting chamber to enable scientists to take precise sediment samples and grow bacteria from them at pressures as high as 1,000 atmospheres. A special ram for the system was produced by the Technical University, Berlin. As well as studying potentially the d...Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections
...y reducing unnecessary antibiotic side-effects and cutting down on the development of antibiotic-resistance in bacteria. * keep the RSV patients separate from other patients who are especially susceptible to infection, such as those undergoing bone-marrow transplants. It is much easier to get approval ...Reversal of role for a viral protein associated with the development of lymphoma
...t 124 fruitfly introns, with up to seven potential cutting steps identified for a single intron. Similar analyses suggest that the same process also occurs in large introns of mammals, including humans, and the Lopez team is now testing this hypothesis experimentally. "The striking evolutionary conservation...Carnegie Mellon University research reveals how cells process large genes
...t 124 fruitfly introns, with up to seven potential cutting steps identified for a single intron. Similar analyses suggest that the same process also occurs in large introns of mammals, including humans, and the Lopez team is now testing this hypothesis experimentally. "The striking evolutionary conservation...Woods Hole Research Center plans controlled burn in Amazon rainforest
...o damage the delicate cambium beneath, permanently cutting off the flow of sap between the roots and the leaves. While most trees in this ecosystem never evolved thick bark to protect themselves from fire, some appear more vulnerable to fire than others, and others that appear to have died soon bounce back b...Compound might defeat African sleeping sickness, clinical trial beginning this month
... take a large drug company to do it, but we're not cutting corners, and we're using some of the best technology and scientists in the world to accomplish these goals," he said. Dr. Carol Olson, vice president and chief medical officer of Immtech, said she and colleagues started the Phase III clinical trial ...Unexpected lock and key mechanism found for the assembly of tumor blood vessels
...mises to lead to a new way to halt tumor growth by cutting off the tumor blood supply. The research team led... ways to stop the proliferation of cancer cells by cutting off their nutrient supply, Varner added. Drs. Varner and Parker are currently in discussions with ph...