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Tag: "customized" at biology news

Nanotechnology meets biology and DNA finds its groove

... help underpin the ability of clinicians to obtain customized DNA profiles of patients. The new work is reported this week (Feb. 8, 2007) in the Proceedings of the National Academies of Science (PNAS) by a team of scientists and engineers from the University of Wisconsin-Madison. "DNA is messy," says Davi...

Engineering the heart piece by piece

...art muscle ?raising the possibility of engineering customized patches to meet the specific requirements of patients. All of these approaches are described in the recent review article. The new article, by Birla and lead author Louise Hecker, a graduate student in the U-M Department of Cell & Developmen...

St. Jude announces breakthrough in eye cancer treatment

...hood cancer, Dyer said. Targeted therapy uses a customized drug to disable a specific molecule inside a growing cancer cell; local delivery is the placement of a drug at the site of disease, rather than systemic treatment. In systemic treatment, such as chemotherapy, a drug is infused into the body through a...

New drug blocks influenza, including bird flu virus

...e most important defense, but new vaccines must be customized in response to an outbreak of disease and it can take as long as a year to formulate and manufacture vaccine in quantity. Antiviral drugs, it is anticipated, would be used to buy time to produce a vaccine in the event of a flu pandemic. And one int...

Progress made in HIV vaccine development

...ns. "Both approaches operate by gene delivery of customized vaccine antigens that are produced by host cells to initiate an immune response. DNA is simple and does not have the problem of anti-vector immunity. However, DNA may be less potent than vector-based gene delivery strategies. Replication-defective...

Nanoparticle assembly enters the fast lane

...y is capped onto individual gold nanoparticles and customized to recognize and bind to complementary DNA located on other particles. This process forms clusters, or aggregates, of gold particles. "It's really by design," Maye said. "We can sit down with a piece of paper, write out a DNA sequence, and contro...

Researchers create genetically matched embryonic stem cells for transplantation

...rinciple of using unfertilized eggs as a source of customized embryonic stem cells that are genetically matched ...e in humans, offers an efficient way of generating customized stem cell lines from women," says George Q. Daley, MD, PhD, senior author on the paper, who is the A...

Knowledge of dendritic cells branches out

...searchers can begin to consider the development of customized immune therapies using this new cell to target specific infections such as HIV, malaria and influenza;certain cancers; and even autoimmune diseases. Dendritic cells (or "DC" ) are specialised white blood cells that patrol the body, searching for inf...

Tetracycline plus teeth equal gray smile

... for every night for three weeks, the patient uses customized trays that deliver the whitening solution to the teeth. During this time period, the patient maintained a meticulous home oral hygiene care and took potassium nitrate, which also decreases sensitivity after bleaching. Then, after the three week time ...

Anti-inflammatory drug's potentially deadly side effect found to be rare

... again as other drugs are developed using the same customized targeting techniques. "This drug is a good example of the potential of developing drugs with very specific biological targets in mind," Clifford says. "But this experience also reminds us that there are a lot of hidden icebergs in the ocean we're n...

How can we protect patients with weakened immune systems from influenza?

...ations. Ultimately, the researchers expect to have customized treatment recommendations for each group. Half of the projects cover children at The Children's Hospital of Philadelphia. One project will study immune responses in children receiving different intensities of chemotherapy for solid tumors and two ty...

Cloned stem cells prove identical to fertilized stem cells

...ing is a promising approach to create individually customized cellular therapies for treating certain disorders. Demonstrated in mice but not in humans, it begins with stem cells derived from a cloned embryo. But if cloned embryos can't produce normal organisms, how can they produce normal stem cells? Analyzin...

Customized gene chip provides rapid detection of genetic changes in children's cancer

Genetics researchers have developed a customized gene chip to rapidly scan tumor samples for specif...rray to include such regions," he added. "We have customized this tool for neuroblastoma, but the approach might also be adapted to other types of cancer in whic...

Researchers identify genes associated with lung transplant rejection

...tion of scar tissue in breathing passages. Using a customized version of a conventional laboratory technique, they found that they were able to look at hundreds of gene products simultaneously in lung tissue samples only a few millimeters across. "That was our first achievement: being able to accurately measure...

Stem cell training program to make its Stanford debut

.... But researchers could also turn Orf2 into a more customized tool by using the techniques of genetic engineering to narrow its activity and tell it exactly which reactions to carry out. “The big advantage that we have with our system is that it’s a small, soluble, easy-to-work-with bacterial protein that seem...

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

.... But researchers could also turn Orf2 into a more customized tool by using the techniques of genetic engineering to narrow its activity and tell it exactly which reactions to carry out. “The big advantage that we have with our system is that it’s a small, soluble, easy-to-work-with bacterial protein that seem...

Using nanoparticles, in vivo gene therapy activates brain stem cells

Using customized nanoparticles that they developed, University at Buffalo scientists have for the first time delivered genes into the brains of living mice with an efficiency that is similar to, or better than, viral vectors and with no observable toxic effect, accor...

Software Tool for Converting Scientific Text into a Database of Functional Relationships

...involved and the effects of regulation, and can be customized to extract other types of information. "The majority of pharmaceutical and biotechnology companies recognize the need for an in-house information extraction technology that would help them to process literature, patent applications and internal text...

Two are better than one

...ay one day benefit from treatment with mixtures of customized antibodies. In a study published recently in the Proceedings of the National Academy of Sciences (USA), a team of Weizmann Institute scientists have demonstrated how the right combination might form a web that destroys the cancer cell's communication...

Asthma gene clusters identified

...genomic data analyses. This, in turn, will lead to customized care based on a patient's personal needs," accordi...o treatment, we will eventually be able to develop customized therapy for patients with different gene expression profiles," she said. ...

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