Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
...behind that inactivation remained unclear. In the current study in mice, the Duke team found that Akt inactivation by dopamine involves the formation of a previously unidentified complex containing beta-arrestin 2, Akt and a third protein phosphatase 2A that inactivates Akt. Mice lacking beta-arrestin becom...Study of energy and health in Africa focuses spotlight on charcoal and forest management
...rding to previous studies by the researchers. The current study, published in the April 1 issue of the journ...ld fuel sources. They gathered a large database of current fuel use in African nations. Using this as a baseline, they defined multiple scenarios for future fu...High-powered gene profiles provide clues to genes involved in common form of lung cancer
... gene abnormalities associated with cancer. In the current study, Dana-Farber researchers used two forms of microarray technology to bring such abnormalities into focus. Using tumor samples from 44 NSCLC patients and 34 laboratory-grown lines of NSCLC cells, investigators scanned the cells with high-resolut...Team Invents Device For Weighing Individual Molecules
... added atoms or molecules. Roukes says that their current generation of devices is sensitive to added mass a...r at the University of Graz, Austria; Xiaoli Feng, current graduate student in electrical engineering; and Dr. Kamil Ekinci former postdoctoral associate, now ...Protein synthesis can be controlled by light, opening way for new scientific, medical applications
...mpounds" has been around for some 30 years. In the current application, the team attached a light-sensitive molecule called a chromophore to a bioactive molecule called an effector through a single covalent bond that inactivates the bioactive molecule. Exposing the caged compound to light releases the effect...MIT engineers an anti-cancer smart bomb
...d beyond 65 days, while mice treated with the best current therapy survived 30 days. Untreated animals died at 20. "It's an elegant technique for attacking the two compartments of a tumor, its vascular system and the cancer cells," said Judah Folkman of Children's Hospital Boston. "This is a very neat appro...The making and breaking of microtubules
...ss of microtubule assembly and disassembly." "Our current work actually revealed the structures of different tubulin assemblies at the very ends of growing microtubules and depolymerizing microtubules," says Wang. "This allows a new understanding of the mechanism of microtubule dynamic instability, opening ...Excess liver gene protects against high-fat diet
...holesterol and lipid metabolism," said Lazar. "The current study elucidates a previously unrecognized role for these liver receptors in the links between diet, serum lipids, and atherosclerosis." Selective modulation of the LXR target genes in liver may therefore ameliorate high lipid levels and cardiovascu...Fat's fate depends on its source
... of Washington University School of Medicine. "The current study supports the notion that the source of fats affects their physiology. New fats are required to burn fat normally and to maintain glucose and cholesterol levels within the normal range. "These findings underscore the importance of a balanced di...Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments
...e an important regulator of circadian rhythms. The current study appears in the June 24 issue of the journal Science. "One of the keys to developing promising new therapies for debilitating neurodegenerative diseases lies in our understanding of how new neurons are created and integrated into mature brain t...Combination therapy leads to partial recovery from spinal cord injury in rats
...rdination. The researchers also used an electrical current test in which they put a magnetic stimulator on th...kull and measured whether the resulting electrical current was transmitted to a muscle in one of the hind legs. Most of the rats treated with the combination ...Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
...a in the biofilm, four of them new to science. The current study now provides nearly half the proteins predicted to be produced by the dominant bacteria, a Leptospirillum group II bacterium, and a smaller proportion from the other bacteria. The lesser coverage of the minor bacteria in the community is due in...UCR chemist part of team identifying new areas of gene regulation
... the cell. Grunstein, one of the scientists in the current team, discovered in 1991 that sites of histone ace...ctivation and repression. The key findings of the current paper were the discovery of this acetylation at the core of the histone, rather than at the proteins...Where Bacteria Get Their Genes
...do this." The research report is published in the current issue of PLoS Biology, available on www.plosbiology.org. Ochman's coauthors are Nancy Moran, UA Regents' Professor of ecology and evolutionary biology and BIO5 member, and Emmanuelle Lerat, now at Universite Claude Bernard (Lyon, France) and Vincent ...Late peak may have prevented severe flu season from becoming worse
...ch month, making the estimates the most timely and current of their kind. In the 2004-2005 flu season, daily CAP discharges peaked at an average of about 7,000 and 8,000, respectively, in January/February 2005 compared to the previous flu season's December 2003/January 2004 peak. Both these seasons had appr...New method shows it is possible to grow bone for grafts within a patient's body
...h, which is based on a dramatic departure from the current practice in tissue engineering, is described in a ...at tissue engineering is done in the future." The current approach currently used by orthopedic surgeons to repair serious bone breaks is to remove small piec...Brown-Harvard team solves mobile DNA's surgical sleight-of-hand
...for about 30 years, much remains a mystery. In the current issue of Nature, a Brown University and Harvard Medical School team reveals the crystal structure of λ-integrase (λ-INT), the protein responsible for this DNA doctoring in the lambda virus, which infects and lives off Escherichia coli (E. coli) bacte...Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
...ternative against infections that are resistant to current antibiotics. And because humans don't have Dam methylation, this kind of drug would not interfere with important biological processes in humans." Other coauthors include Dr. Stanley Hattman, professor of biology from University of Rochester, who clo...ORNL, UC Berkeley unravel real-world clues to Earth's mysteries
...xes, the molecular machines of life. "Most of the current work looks at single microbial organisms grown under controlled laboratory conditions, but the longer-term plans are to extend this work to real-world microbial communities -- the natural state of these systems in the environment," Hettich said. "Thi...Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief
...new drug therapies that will completely bypass the current arguments over the use of medical marijuana. In theory, the new research makes it possible to design a pill that will have the same pain relieving effects as smoked marijuana, but through an indirect mechanism that could also reduce unwanted psychoac...