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Tag: "current" at biology news

An HIV Protein Plays a Surprising Role in Gene Activation

...viral replication. It affects these processes, the current model holds, by stimulating transcript elongation and increasing RNA polymerase's processing efficiency. In a new study, Tamal Raha, Grace Cheng, and Michael Green work with human cell lines and find evidence that Tat can also stimulate PIC assembly....

Gene variations explain drug dose required to control seizures

... where they act in the body," Goldstein said. "The current results support the idea that known drug targets, transporters and drug metabolizing enzymes are good starting points for understanding variation among patients in drug response." In Parkinson's disease, for example, a pharmacogenetic test might ass...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... in total occur in about one in 5,000 births. The current study is part of a large, collaborative effort at Duke University Medical Center to find an effective treatment for Pompe disease. The Duke team earlier developed enzyme replacement therapy, in which a normal version of the faulty enzyme in those wit...

Purdue proves concept of using nano-materials for drug discovery

...who wrote a paper that details new findings in the current issue (Feb. 15) of the journal Langmuir. The two other researchers are Zhigang Wang, a postdoctoral fellow at Purdue; and Richard Haasch, a research scientist at the University of Illinois at Urbana-Champaign. The work is part of overall research be...

Scientists rid stem cell culture of key animal cells

... the safe clinical use of many, if not all, of the current cell lines now in use. Until now, scientists have had to grow and sustain stem cells through the tedious daily task of generating mouse feeder cells from mouse embryos. Feeder cells, or fibroblasts, are connective tissue cells that form the matrix u...

U-M scientists find genes that control growth of common skin cancer

... recurrence may be particularlyimportant given the current efforts to develop Hh pathway inhibitors asa means of combating human BCCs, as well as other cancers. In contrastto other cancer models where inhibition of Hh signaling leads todurable tumor regression, Dlugosz's new work raises the possibilitythat H...

Genetically modified natural killer immune cells attack, kill leukemia cells

...Results of the St. Jude study are published in the current online issue of Blood. The researchers demonstrated how to overcome significant technical hurdles that have until now slowed development of NK-based therapies for ALL, according to Dario Campana, M.D., Ph.D., a member of St. Jude Hematology-Oncology...

Study shows nanoshells ideal as chemical nanosensors

... delivery and rapid whole-blood immunoassay.In the current study, Halas and former graduate student Joseph B.Jackson, now with Nanospectra Biosciences, Inc., created thin films ofnanoshells deposited atop plates of glass. Films with various densitieswere studied, as were films containing both silver and gold...

Scientists identify genetic pathways essential to RNA interference

...o viral infection, among other functions. For the current study, lead author John Kim, PhD, and his colleagues developed a strain of C. elegans into which they added a gene that caused the worms to glow under ultraviolet light but also turned that gene off using RNAi. They then used RNAi to inactivate every...

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

...anding of heredity at the molecular level. “Major current advances in science and biotechnology, such as genetic engineering, the mapping of the human genome, and genetic fingerprinting, all have their origins in Crick’s inspired work,?said Donald A.B. Lindberg, M.D., director of the National Library of Med...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...disease. Levodopa, considered the gold standard of current treatment, enables the brain to replenish its dwindling supply of dopamine, sidetracking the destructive course of Parkinson's disease. But eventually the treatment can backfire. “Levodopa generally works great for several years, but then it actuall...

Scientists discover unique microbe in California's largest lake

...of 376 square miles insoutheastern California. Its current elevation is about 227 feet belowmean sea level, its maximum depth reaches 51 feet and its total volumeis about 7.5 million acre-feet. It was formed in the early 1900s, whenflow from the Colorado River was inadvertently directed to the SaltonBasin. O...

HIV Infection Still On The Rise

...ach year, while the lifetime costs of care for the current 50,000 infected individuals in the United Kingdom, with a life expectancy of 20 years, is at least £12.5bn. "Prioritisation of sexual health with substantial investment is essential to avoid continuing deterioration in services, rising HIV transmiss...

NC State scientist finds soft tissue in T. rex bones

...s, and other recognizable organic features. Since current data indicates that living birds are more closely related to dinosaurs than any other group, Schweitzer compared the findings from the T. rex with structures found in modern-day ostriches. In both samples, transparent branching blood vessels were pre...

Study Models Impact Of Anthrax Vaccine

... taking antibiotics until 9 days afterexposure.The current licensed anthrax vaccine requires six doses over an18-month period to provide immunity. The researchers looked at whatimpact a new and improved anthrax vaccine could have, and evaluated arange of vaccine characteristics, which could begin to provide ...

Tiny scaffolding allows stem cells to become working fat cells

...io State University, reported this progress in the current issue of the journal Tissue Engineering. "There i...living tissue, they would offer a better test than current two-dimensional cell colonies provide." Kniss is currently working with an Ohio company to consider ...

NJIT Presidential Award winner takes stem cell research another step

...fering from other disorders. We are looking at the current treatment for repairing bone defects, which is the use of allograft tissue, as well as newer treatments such as combining allograft with stem cells." One day soon, as a result of Arinzeh's research, patients could be treated with off-the-shelf stem-...

Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications

... structural ordering and range of pore sizes. Most current technologies can only produce 2-dimensional hexagonal structure with small pore diameter ( IBN’s simple wet-chemical technique uses two different types of surfactant (a soluble chemical compound that reduces the surface tension between liquids). One...

Boosting HIV screening can increase survival and is cost effective

... a handful of easily identifiable risk groups, yet current approaches to HIV testing are still focused on these sub-populations. The result is that 280,000 Americans with HIV remain unaware of their infection. Efforts to promote and finance routine, population-based HIV screening should be pursued aggressive...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

... Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in which the antibody-producing cells (B lymphocytes) multiply uncontrollably and crowd out other blood cells. The St. Jude researchers report that TEL2 cooperates with MYC to increa...

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