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Tag: "cultures" at biology news

Scientists and engineers apply nature's design to human problems

... solutions adapted from natural systems and native cultures and then applies these solutions to fundamental environmental, economic and social challenges. Its long-term goal is to engage leaders in various fields in a conversation and learning process to help them understand the root causes of the region's ec...

Modifications render carbon nanotubes nontoxic

...ells. In cytotoxicological studies, identical cell cultures are exposed to various forms and concentrations of... current study, CBEN researchers exposed skin cell cultures to varying doses of four types of water-soluble single-walled carbon nanotubes, or SWNTs. The four i...

Scientists closer to new cancer detection method

...ng molecularly engineered strands of DNA into cell cultures and observing whether they unleash a fluorescent burst after they adhere to cancer proteins. The technique could enable doctors to search within extremely complex fluid or tissue samples to pinpoint biomarkers - proteins that signal that something ...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

... including multiple sclerosis. Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often ignored in favor of T-cell targets in standard therapies. FLT3, which controls the development of healthy bl...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...involved with cell proliferation. Using human cell cultures infected with the Epstein-Barr virus, the investigators found that EBNA3C recruits a group of molecules called the SCF complex, which attaches ubiquitin to Rb. This inadvertently tags Rb for degradation by the proteosome machinery, the cell's recycli...

Molecular cabal contributes to stroke damage

...of calcium. Importantly, the researchers found in cultures of neurons that drugs that inhibited NMDAR or CaMKII prevented the ischemia-induced enhancement of ASIC sensitivity, as well as neuronal death. "In summary, our report provides a functional linkage between NMDAR-mediated exitotoxicity and ASIC-media...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...ell disease, a viral vector was introduced in cell cultures of patients who have the disease. The vector carried a therapeutic globin gene harboring an embedded small interfering RNA precursor designed to suppress abnormal hemoglobin formation. Tested in adult stem cells from SCD patients, researchers found ...

New methods offer insight into regulatory DNA

...with estimates of gene activity obtained from cell cultures from 60 individuals who provided samples for the H...re, with the power of the HapMap data and the cell cultures available, will speed that transformation. ...

Scientists directly view immune cells interacting to avert autoimmunity

...ns experimentally in living organs or even in cell cultures has been impossible before now, the scientists note. Their long-term aim is to use such imaging to diagnose immune diseases such as type 1 diabetes, and to further develop therapies that act at the level of T cell interactions. The research, publish...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

...o an H5N1 vaccine, including vaccines made in cell cultures rather than grown in eggs. H5N1 avian influenza viruses are of enormous concern to public health officials worldwide. The potential for a human avian flu pandemic looms large, say experts, as daily reports indicate an increasing spread of infection ...

Pain killer fights breast cancer by targeting key enzyme

...on form of breast cancer, a new study using tissue cultures suggests. The drug is called nimesulide. In laboratory experiments on breast cancer cells, scientists found that derivatives of nimesulide stopped the production of aromatase, the enzyme implicated in estrogen-dependent breast cancer. This form of b...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

... antigens but do not elicit ADCC. "Mammalian cell cultures currently used for most therapeutic protein production produce a mixture of glycoforms and typically do not allow for the control of glycosylation," said Tillman Gerngross, chief scientific officer of GlycoFi, and professor of Bioengineering at Dartm...

Clues to breast cancer hidden inside stem cells

...f Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties about these stem c... Biologists have long relied on 2-dimensional cell cultures as the basic tool of their trade. But there is a big difference between a flat layer of cells and cu...

Testes to incubate stem cells

...University Medical Centre in Rotterdam. Testicular cultures could also prove an ideal system to test compounds that might affect sperm-production such as endocrine disruptors or therapeutic drugs. ...

Earth Rx: A microbial biotechnology prescription for global environmental health

...tarted back in the 1940s and 1950s, when microbial cultures were initially sorted by size and shape. Before the modern DNA-based techniques, the function of a microorganism was assigned by selective culturing on agar plates or a nutrient-rich broth and selecting on the basis of metabolic function, which turn...

Does father know best?

... but little is known about how this differs across cultures and to what extent men's paternity assessments reflect actual biological paternity. "The issue of paternity--whether a man really is the biological father of his supposed children--has long been a topic of interest to anthropologists, as well as a...

Molecular force field helps cancer cells defend against attack

... identified FAK's interaction with VEGFR-3 in cell cultures of human breast cancer. Breast cancers that pump out high volumes of FAK and VEGFR-3 are more aggressive tumors, Cance said. The scientists were able to block FAK from binding with VEGFR-3 by introducing a different protein that stopped cancer cells ...

Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers

It has been well documented that, across human cultures and in most mammals, males are usually more aggressive and less nurturing than females. It's simple to blame male hormones, like testosterone, for male behavior such as aggression. But maybe it's in our genes, too. Indeed such social behavior also h...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

... We've now been able to show in these cardiac cell cultures that electric pulses sometimes break rotating waves rather than block them." Engineered cardiac tissues also might prove a useful testing ground for potential drug and gene therapies that could restore normal heart rhythms, he added. "Bursac and Tu...

New method for identifying microbes

...ntify potential threats to human health." Growing cultures of microbes to identify species is slow and error prone as the culture conditions often screen out important members of the community. Sequencing entire genomes, while highly specific and informative, would be too labor intensive and costly. So scien...

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