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Tag: "cultures" at biology news

Achilles heel of the herpes virus possibly found

... cells and susceptible pig cells by adding to cell cultures a synthetic peptide made to mimic the structure of a smaller region of the B5 receptor. This peptide looks like a functional region of B5 and apparently interferes with virus engaging of the cell receptor. The papers detail how the team isolated and...

Study: Harmless virus kills some cancers

... which are natural hosts for both AAV2 and HPV. In cultures infected with both AAV2 and HPV, the team found that after six days, all HPV infected cells had died. Meyers then used the same approach in four types of cancer ?cervical, breast, prostate and squamous cell - all epithelial cell cancers. Epithelial c...

USC researchers determine mechanism of action of chemotherapy drug

...from human lung, prostate and lymphoma cancer cell cultures that had been treated with motexafin gadolinium, or MGd. What they found was that the drug created oxidative stress in the tumor cells, increasing the levels of expression of the genes that produce metallothioneins. The researchers showed that the i...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

... yielding no living mast cells was observed in the cultures that received IFNγ. Similar results were reported in vivo using a mouse model. Mice with a mutation that causes them to overproduce IFNγ were used, and again, researchers observed a significant decrease in mast cell numbers due to the exce...

Climate model links higher temperatures to prehistoric extinction

... yielding no living mast cells was observed in the cultures that received IFNγ. Similar results were reported in vivo using a mouse model. Mice with a mutation that causes them to overproduce IFNγ were used, and again, researchers observed a significant decrease in mast cell numbers due to the exce...

Most common lung cancers may begin in newly discovered cells

...ra or alveolar cells lining the airways. In tissue cultures of normal mouse cells, only the BASCs could grow m...ferentiate into Clara or alveolar cells. In tissue cultures of the mutant mouse lung cells, the activated oncogene only triggered growth of the BASCs, not of th...

Missing Receptor Molecule Causes Tumor Growth

...t the real causes of disease much better than cell cultures commonly used for experimental research. It was determined that in 20% of the tissues examined the gene responsible for DR4 was methylated to a higher degree and DR4 was missing. This research supported by funding from the Austrian Science Fund, FWF...

Nanoparticles carry cancer-killing drugs into tumor cells

...t the real causes of disease much better than cell cultures commonly used for experimental research. It was determined that in 20% of the tissues examined the gene responsible for DR4 was methylated to a higher degree and DR4 was missing. This research supported by funding from the Austrian Science Fund, FWF...

Compound from Chinese medicine shows promise in head and neck cancer

...y, researchers developed head and neck cancer cell cultures resistant to the chemotherapy drug cisplatin, a pl...earch, Bradford, Carey and their team treated cell cultures of head and neck squamous cell carcinoma with the (-)-gossypol compound and found it inhibited tumor...

A novel method to measure circadian cycles

... from humans and infected subsequently made tissue cultures with a virus engineered to report with a fluorescent signal when a certain host circadian rhythm gene was expressed. They found that their data jibed with the previously accepted length of the human circadian cycle: 24.5 hours. Because of the sensit...

Researchers create infectious hepatitis C virus in a test tube

... form of the hepatitis C virus (HCV) in laboratory cultures of human cells. The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around t...

Rodent social behavior encoded in junk DNA

...individuals. The researchers first showed in cell cultures that the vole vasopressin receptor microsatellites could modify gene expression. Next, they bred two strains of a monogamous species, the prairie vole ?one with a long version of the microsatellites and the other with a short version. Adult male offs...

Identical twins may have more differences than meet the eye

...dings of this study to what he sees in cancer cell cultures in his laboratory. "Nearly every tumor, every human malignancy shows changes in DNA methylation that mess up gene expression," he said. "If we understand what regulates methylation patterns, then we may be able to develop better treatment options fo...

Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico

...dings of this study to what he sees in cancer cell cultures in his laboratory. "Nearly every tumor, every human malignancy shows changes in DNA methylation that mess up gene expression," he said. "If we understand what regulates methylation patterns, then we may be able to develop better treatment options fo...

Molecular trigger for Huntington's disease found

...in the pathologies of HD. Their studies with cell cultures showed that the abnormal HD protein selectively bi...s target genes in cell nuclei. In studies of cell cultures and of mice engineered to have HD, the researchers found that the p53 increase causes malfunctions i...

Firefly protein lets researchers monitor molecule linked to cancer

...time measurements of light from luciferase in cell cultures and in cells within live animals. To use the firefly protein to monitor IKK, Gross altered cell lines to genetically fuse the luciferase protein to IKB (IKappaB), the protein that comes immediately after IKK in the NF-KappaB pathway. When the pathwa...

New study finds how cells with damaged DNA alert the immune system

...em plays a significant role." The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of ...

Renewed hope for Parkinson's patients

...em plays a significant role." The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of ...

OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis

...ut life. Back's lab provided the team with tissue cultures of immature rat oligodendrocytes. The researchers then applied HA to these cells which indeed kept the immature cells from maturing into myelin-producing cells. In another key experiment, Sherman and Back confirmed in another animal model of MS that ...

Molecular Partners Required For Appropriate Neuronal Gene Repression

...ut life. Back's lab provided the team with tissue cultures of immature rat oligodendrocytes. The researchers then applied HA to these cells which indeed kept the immature cells from maturing into myelin-producing cells. In another key experiment, Sherman and Back confirmed in another animal model of MS that ...

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