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Tag: "crystallography" at biology news

Yale scientists identify structure for RNA quality control

... Wolin in the department of Cell Biology used both crystallography and biochemistry to visualize how Ro interacts wit... Wolin in the department of Cell Biology used both crystallography and biochemistry to visualize how Ro interacts with these RNAs. "The crystal structures of Ro revea...

Cells direct membrane traffic by channel width

...rchers have solved a mystery that years of protein crystallography couldn't accomplish. Reporting in the August issue of Structure, they show that the main structural difference that makes an aquaporin a glycerol channel is a channel that is just a hundred-millionth of a centimeter -- an angstrom -- wider than a nor...

Researchers find how some antibiotics kill bacteria

...ce. The researchers used a technique called X-ray crystallography to determine where individual atoms are located within a crystal structure. From this information they then created high-resolution computer models of each antibiotic, approximating what each substance looked like on the atomic level and exactly how ...

Unweaving amyloid fibers to solve prion puzzles

...l techniques used to image proteins, such as X-ray crystallography and nuclear magnetic resonance imaging, don't work with fibrous structures such as amyloids. And scientists depend on these high resolution images of molecules in order to study their function. Now, researchers have found a way to work around these ...

Major advance made on DNA structure

...onal Academy of Sciences that they have used X-ray crystallography to determine the three-dimensional structures of nearly all the possible sequences of a macromolecule, and thereby create a map of DNA structure. As work of this type expands, it should be fundamentally important in explaining the actual biological ...

The making and breaking of microtubules

...bulin in its stable, straight form, using electron crystallography methods, in which two-dimensional arrays of tubulin "flat" polymers were studied using cryo-EM and electron diffraction. By "docking" this crystallographic model within the structures they have now obtained for the polymerization intermediates at mo...

Malaria mechanism revealed

...g and treating malaria--the researchers used x-ray crystallography to determine the atomic structure of a key portion of the EBA-175 protein called the RII domain. The results revealed that two molecules of RII come together in a manner resembling a handshake, and that the overall shape of such RII "dimers" resembl...

Supercomputers to focus brains on AIDS dilemma

...o. In 1999, related results from traditional x-ray crystallography studies of the structure of a complex between the HIV-1 integrase catalytic domain and an inhibitor pointed to the existence of only one site where inhibitors could bind. These studies indicated a single format for small inhibitors of integrase to bi...

Researchers make gains in understanding antibiotic resistance

... experiments, Steitz and his colleagues used x-ray crystallography to do high-resolution structural analyses of the l...ill bacteria. Finally, the researchers used x-ray crystallography to explore at high resolution the structural basis of a particular ribosomal mutation dubbed L22 tha...

Research advances quest for HIV-1 vaccine

...ion of 4E10 with gp41 influences the virus. X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researchers identified the specific amino acids on gp41 that 4E10 inte...

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