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Tag: "critical" at biology news

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

... striking and surprising exception in the way some critical genes are activated by the protein packaging. These proteins act like spools for the long strings of DNA that contain our genes and form chromosomes. The researchers studied chemical tags that are attached to the spools and switch on the genes they w...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...cience manuscript. "These data point us toward two critical and exciting questions: What are the functions of these previously unannotated transcripts and what are the regulation schemes that orchestrate such complex assemblies of transcription? It seems certain that this is not the genome we learned about wh...

Critical role in programmed cell death identified

...nfirmation yet that mitochondrial fragmentation is critical in killing cells. C. elegans worms are a convenient model system, Conradt explained, with a well documented cell lineage that facilitates genetic manipulation. Their cell death machinery is simple, with one component for each of the different factor...

Nanogen Issued Patent for Electronic Microarray With Memory

...for developing molecular diagnostic tests. Storing critical voltage information allows for precise control of the biological molecules during analysis and increases data management efficiency by tracking test site activation and array usage directly on the electronic microarray cartridge. "This addition to o...

Development of portable infectious disease detector

... skin,etc.--this approach also can rapidly provide critical insights into itsmode of action."Pria has an outstanding understanding of the clinical and diagnosticdevice market and the ability to rapidly prototype optical andmicrofluidics devices," says Wikswo, "but it is difficult for thecompany to survey larg...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...need for biologists,"explained Dr. Brent. "It is a critical step forward in our quest toprovide an accurate simulation of intracellular biochemical networks.""I've designed Moleculizer to be intuitive for biologists," said Dr.Larry Lok, a mathematician who conceived and programmed Moleculizer."Its parallel si...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...ediately by light alone." The techniques could be critical to advancing early detection, diagnosis, and treatment of disease. More technically put, "To rapidly assess the health of a single mammalian cell," says Gourley, "the key discovery was the elucidation of biophotonic differences in normal and cancer ...

International trial of two microbicides begins

... Team Leader in NIAID's Division of AIDS. "It is a critical trial evaluating two topical microbicides with differing mechanisms of action," she adds. The microbicides to be tested are PRO 2000 and BufferGel. Produced by Indevus Pharmaceuticals, Lexington, MA, PRO 2000 has shown activity against HIV and other...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...ular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pat...

Genetic Variation Visualization - From EMBL

...ular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pat...

MetaChip provides quick, efficient toxicity screening of potential drugs

... Team Leader in NIAID's Division of AIDS. "It is a critical trial evaluating two topical microbicides with differing mechanisms of action," she adds. The microbicides to be tested are PRO 2000 and BufferGel. Produced by Indevus Pharmaceuticals, Lexington, MA, PRO 2000 has shown activity against HIV and other...

New Mixing Method for Microchip-Sized Labs

...ular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pat...

UCSD discovery may help extend life of natural pesticide

...uggested that specific sugar structures are likely critical for Bt toxin susceptibility," said Joel Griffitts, the first author on the paper and a former graduate student with UCSD biology professor Raffi Aroian. "This latest paper demonstrates what these sugars actually do. They provide a receptor for the to...

Study of genomic DNA leads to new advances in cancer diagnostics

...s process. Changes to the ECM and cytoskeleton are critical to migration of a cancer cell from one site in the body to another. The researchers could alter the Alu I sensitivity of a cell's chromatin by exposing the cell to a single extracellular matrix molecule or by disrupting any of three cytoskeletal sys...

White blood cell waste disposal system plays critical regulatory role

A new research study identifies a critical inhibitory step that is a key component of the fee...ditions characterized by abnormal numbers of these critical immune cells. Human neutrophils are white blood cells that are constantly being produced in the bon...

Agilent Technologies releases automated literature search tool for biology researchers

...ation about proteins and protein interactions is a critical step for building models of cells," said Trey Ideker, assistant professor at the University of California, San Diego, and lead researcher/program manager for the Cytoscape project. "Agilent's Literature Search plug-in for Cytoscape makes automatic li...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...covered. It is also likely that mutations in these critical sequences cause human diseases. Studying how such mutations drive development astray may lead to better understanding not only of these diseases, which are likely to be rare, but also of normal human development. ...

Scientists solve structure of key protein in innate immune response

...that amino acid residues comprising the pocket are critical for LPS binding. Most, if not all, of the CD14 ligands compete with LPS for CD14 binding. Therefore, they probably share the same binding pocket with LPS." Ligands other than LPS can be accommodated in the pocket due to its large size, the flexibili...

Love at first smell

...ng only males with the correct mix of immune genes critical for the survival of future offspring. In the experiment females were fooled by the protein fragments into believing that males with insufficient MHC molecules would provide offspring with the ideal number of MHC types. However, when the perfume was ...

Scientists find fossil proof of Egypt's ancient climate

...e suggests that 100,000 to 400,000 years ago was a critical time in the evolution and dispersal of African hominins. Our climate data from this 130,000-year-old humid event suggest that this would have been a particularly good time for a northward migration through Africa following reliable water resources, s...

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