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Tag: "corrective" at biology news

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... researchers also said their approach of targeting corrective genes to muscles may have application in treating other muscular dystrophies. Patients with Pompe disease have a defect in a key enzyme that converts glycogen, a stored form of sugar, into glucose, the body's primary energy source. As a result, glyc...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...ing the disease in its later stages. By inserting corrective genes into the brain, scientists studying small monkeys called marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells, said Ron Mandel, Ph.D., a scientist with the University of Florida's McKnight...

Gene therapy for Parkinson's disease moves forward in animals

...ing the disease in its later stages. By inserting corrective genes into the brain, scientists studying small monkeys called marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells, said Ron Mandel, Ph.D., a scientist with the University of Florida's McKnight...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...nto cardiac failure. The polyoxamer had an instant corrective effect in the mdx mice, which really surprised us." In future research, U-M scientists want to test P188 on mice with other types of dystrophies and see if it works as well when given as injections, rather than infusions. Metzger emphasizes that it...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

... by Dr. Xiao and his colleagues for delivering the corrective gene is known as adeno-associated virus, or AAV, a...scular injection is not practical for delivering a corrective gene to the body's more than 600 muscle groups. Recently, Dr. Xiao's team demonstrated that a type ...

Ancient DNA helps UF researchers unearth potential hemophilia therapy

... success, Fletcher said. Researchers usually hide corrective genes inside viruses, which then infect cells. Without the virus to act as a key, the gene would be unable to enter the cell. But viral gene therapy has been associated with medical complications, and a few human patients have died as a result. Inst...

Secrets of the sea yield stronger artificial bone

... inflammation and immune responses, or may require corrective surgery after only a few years. The need for better biomaterials is further underscored by the growing demand for artificial joints. More than 150,000 hip replacement and nearly 300,000 knee replacements were performed in 2000, according to the Natio...

UF scientists test improved gene therapy method for hereditary heart conditions

A new way of delivering corrective genes with a single injection into a vein holds pr...he vector into a vein like any other drug, and the corrective gene collects in the heart." Scientists say gene therapy looks increasingly feasible for the treat...

Ultrasound may help regrow teeth

...rocess while allowing for the continued wearing of corrective braces. With approximately five million people in North America presently wearing orthodontic braces, the market size for the device would be 1.4 million users. In a true tale of interdisciplinary work, El-Bialy met Chen at the U of A's new staff or...

Snakes' virtual glasses, leopard spots and all-optical transistors

...ancement as though the snakes were wearing virtual corrective lenses. Because snakes' brains are small, the physicists kept their model of an image enhancing network simple. They discovered that even a crude network dramatically improves infrared imaging - which you might want to keep in mind if you ever book a...

Scientists take 'snapshots' of enzyme action

...are not properly metabolized, and possibly develop corrective measures. One example is a condition called trimethylaminuria, also known as "fish odor syndrome," which results from defective FMOs. Affected individuals are unable to oxygenate trimethylamine, a byproduct of protein digestion released by bacteria ...

Gene therapy for hereditary lung disease advances

...this case an adeno-associated virus - to deliver a corrective gene to 12 patients who are unable to produce a protein essential for health called alpha-1 antitrypsin. "The primary end point in the trial was to see whether it was safe to give patients this gene transfer vector and then to try to begin to see...

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