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Tag: "core" at biology news

Imaging Lymph Nodes with Nanoparticles

...cles contain a centralsuperparamagnetic iron oxide core and are covered by dextran, impartinglong circulation times and biocompatibility. When injectedintravenously, the nanoparticles localize to lymphoid tissue, and areinternalized into macrophages. There is then a decrease in signalintensity on T2- and ...

An HIV Protein Plays a Surprising Role in Gene Activation

...iption factors were “virtually undetectable?at the core promoter in the absence of Tat. Adding Tat recruited all the usual transcription factors to the promoter and increased transcription. But none of the TAFs that normally associate with TFIID were found. When the authors used the activator Gal4-VP16 to...

BRCA1 causes ovarian cancer through indirect, biochemical route

...ry and molecular biology and director of the mouse core facility at the USC/Norris Cancer Center. "The whole project was based on creating a mouse that lacks BRCA1 in only its granulosa cells," Dubeau says. "This collaboration was essential to the project's success." What Dubeau and his colleagues found ...

New research questions basic tenet of neuron function

...ent release. "These findings question one of the core tenets of synaptic function and reveal significant complexity in organization of synaptic vesicles within individual synapses," said Dr. Ege Kavalali, assistant professor in the Center for Basic Neuroscience and of physiology at UT Southwestern and s...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

..., "and what we ended up with were two compounds -- core macroketone and core macrolactam -- that are about 1,000 times more powerful at inhibiting cancer cell migration." In fa...

Study shows nanoshells ideal as chemical nanosensors

... of a virus. They are ball-shaped and consist of a core ofnon-conducting glass that is covered by a metallic shell, typicallyeither gold or silver. The metal shell "captures" passing light andfocuses it, a property that directly leads to the enormous Ramanenhancements observed. Furthermore, nanoshells can...

Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed

...ed by University of Washington researchers, an ice core of 1,000 meters was used as a sort of dipstick to ...he Last Glacial Maximum. But evidence from an ice core extracted near Siple Dome from 1997-99, along with other calculations, indicates ice in that area ha...

The BIOS Initiative - open source biotechnology is born

...licensing mechanism that encourages sharing of the core tools of innovation with all, while still allowing patenting of products, where necessary. Not content with inventing new technology and new software communities, CAMBIA is also releasing new functionalities in its highly successful Patent Lens, whi...

Multiple Campylobacter Genomes Sequenced

...detailed comparative genomic analysis provides the core blueprint for this important family of human pathogens. And in doing so, it lays the foundation for the development of new ways to monitor and control Campylobacter in the food chain and in human infection. ...

Wisconsin researchers identify sleep gene

Zeroing in on the core cellular mechanisms of sleep, researchers at University of Wisconsin Medical School have identified for the first time a single gene mutation that has a powerful effect on the amount of time fruit flies sleep. In its normal state, the Drosophila (fr...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...nd ingredient that consists of a gold nanoparticle core surrounded by hundreds of identical DNA strands, which serve as hundreds of "bio-bar-codes" the researchers can detect at the end of the test. Ultimately, the gold-DNA particles and magnetic particles sandwich the biomarker targets. A magnet separat...

Products containing specific probes for detecting alternative splice forms protected

...he granting of these claims build on the company's core assets further expanding our IP position in the field of gene expression and profiling," stated Bruno Tocque, President and CEO, ExonHit Therapeutics. "This is a significant event for ExonHit as we have been quite successful in leveraging strategic a...

Researchers find new genes necessary to make embryo

... of regulation to lend adaptive functions to these core networks." ...

Buying Time Through Hibernation on Demand

...ute to fewer than 10 breaths per minute, and their core temperature dropped from the normal 37 degrees Cel...er our metabolic flexibility. It's what allows our core temperature to stay at 98.6 degrees, regardless of whether we're in Alaska or Tahiti," Roth said. I...

U-M team recovers ancient whale in Egyptian desert

...ute to fewer than 10 breaths per minute, and their core temperature dropped from the normal 37 degrees Cel...er our metabolic flexibility. It's what allows our core temperature to stay at 98.6 degrees, regardless of whether we're in Alaska or Tahiti," Roth said. I...

Different microarray systems more alike than previously thought

...s of time and reagents from participating labs and core facilities. Authors of the report are Rafael Irizarry of the Johns Hopkins Bloomberg School of Public Health; and Forrest Spencer, Daniel Warren, and Irene Kim of the Johns Hopkins School of Medicine. ...

Protein helps regulate the genes of embryonic stem cells

... the form of chemical modifications on any of four core histone proteins that group together to provide a molecular scaffold supporting the roughly 35,000 genes in the nucleus of every human cell. Histone modifications affect gene activity and include methylation, in which a methyl component is attached t...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...that is required for telomerase activity, at whose core three strands of RNA come together to form a triple helix. All vertebrate animals investigated so far have nearly the identical sequence of nucleotides through the triple helix, Theimer said. "The triple helical structure of the pseudoknot must be si...

Measles Deaths Worldwide Drop By Nearly 40% Over Five Years

...a. Launched in 2001, this successful partnership's core founding members are WHO, UNICEF, the American Red Cross, the United Nations Foundation and the Centres for Disease Control and Prevention of the United States Department of Health and Human Services.. Since 2001, the Initiative has mobilized more th...

wFleaBase: the Daphnia genome database

...jects. This new database is built primarily from core components of the Generic Model Organism Database project, and related bioinformatics tools. Over the coming year, preliminary genetic maps and the nearly complete genomic sequence of Daphnia pulex will be integrated into wFleaBase, including gene p...

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