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Tag: "copy" at biology news

Scientists identify a gene that may suppress colorectal cancer

...rbingers of cancer. When these mice possessed one copy of the mutated gene, the incidence of small intestinal and colon polyps were reduced by about 90%. “This gene may give us a novel target to aid in the diagnosis, prevention, and/or treatment of cancer,?says Dr. Arthur Buchberg, one of the co-senior ...

Largest genomic search finds genes that may contribute to autism

... the team scanned the same DNA for what are called copy number variations. These are submicroscopic inser...sm and other common diseases. Schellenberg said copy number variations are fairly common in the human genome and many of them are believed to be benign. ...

How genetic malfunction causes a form of retardation

... Like humans with NS, the mice had only one mutant copy of the SHP-2 gene, while the other was normal. The researchers observed in the animals?brains increases in neuron density and percentage, as well as a large decrease in glial cells called astrocytes. “Little is known about how genetic perturbation...

Gene that makes people 'early to bed and early to rise' demystified

...a dominant fashion, meaning that it takes just one copy of the abnormal gene to exhibit symptoms. The UCSF group had earlier discovered a variant of the human Per2 gene that causes FASPS. They also showed that the so-called "S662G" variant, in which the serine building block normally present at position...

Researchers discover gene crucial for nerve cell insulation

...he researchers discovered how a defect in just one copy of the gene, known as early growth response gene 2 (EGR2) affects the normal copy of the gene as well as the functioning of other genes, resulting in peripheral neuropathy. "The r...

Autism gene identified by researchers at Yale working with a global research consortium

... families. They also scanned the DNA to search for copy number variations, which are submicroscopic insertions and deletions of genetic material that scientists believe may be linked to autism and other diseases. The researchers found neurexin 1, part of a family of genes that plays a role with the neurot...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...f Kras and an early mutation of Dcp4, in which one copy of the suppressor gene is eliminated, lead to cancer by a different path, beginning with the creation of a distinct class of precancerous lesions in the ductal epithelium called mucinous cystic neoplasms (MCN). This initiates a process that results i...

Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

...ct to duplication, indicating that having an extra copy of a gene may enable it to evolve more rapidly and that small duplications are a key feature of primate evolution. The analysis also revealed a few instances in which whole families of genes were radically different in the rhesus, containing more...

Cold sore virus might play role in Alzheimer's disease

... the mouth ?in the 25 percent of people who have a copy of the ApoE-4 gene. In other words, people who are...hat such damage is worse in people with the ApoE-4 copy of the gene. Earlier this year Federoff's team published a study that showed inflammation is the ear...

Common gene version optimizes thinking -- but with a possible downside

...Three fourths of subjects studied had at least one copy of the version that results in more efficient filtering of information processed by the brain's executive hub, the prefrontal cortex. However, the same version was also more prevalent among people who developed schizophrenia, a severe mental illness ...

Veterinary scientists explore poultry virus as cancer killer

...mbinant virus from cloned complimentary DNA (cDNA) copy of a viral genome, explains Subbiah. Through the reverse genetics system, recombinant viruses can be designed to have specific properties that make them attractive as biotechnological tools, live vaccines, and cancer therapeutics. This is achieved th...

Danish researches solve virus puzzle

...he host cell where it liberates its RNA which is a copy of the heritage material, DNA. RNA is like a 'cook book' which contains the recipes of which proteins the virus needs for replication. The work process of a virus The cell has ribosomes, a kind of 'molecular motors', which move along the RNA...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...rested in attending the meeting and/or receiving a copy of the book of abstracts. PROGRAM HIGHLIGHTS The following items describe some highlights from among the many papers being given at the meeting. Full abstracts of the presentations mentioned below can be viewed at the ASA Meeting Abstracts Da...

Herpes virus hijacks DNA repair process

...rs, or mistakes accidentally introduced when cells copy their genetic material prior to dividing. In the murine (or mouse-infecting) herpes virus they studied, researchers at Washington University School of Medicine in St. Louis identified a protein that can trick the mouse cell into turning on the DNA...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

...r techniques, you can usually incorporate only one copy of your gene cargo to each bacterium or virus particle," Akin said. In the new approach, bacteria can carry hundreds of nanoparticles, each of which can in turn carry hundreds of drug molecules, depending on the size of the nanoparticles. The a...

'Lucky 13' as new gene discovery offers further hope for childhood blindness

...has been lost completely, but carriers of just one copy of the mutation, who will almost certainly have reduced protein levels, nevertheless function perfectly normally," explains Professor Inglehearn. "This being the case, restoration of even a tenth of the missing protein may be enough to restore vision...

Common cancer gene sends death order to tiny killer

...essenger RNAs and, like crumpled paper jammed in a copy machine, prevent proteins from being made. Josh Mendell, M.D., Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine, suspected that p53 activates microRNAs like miR-34a because a number of studies have demonstrated ...

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