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Tag: "copy" at biology news

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

... people of European descent may carry at least one copy of this SNP in the NOS1AP gene. According to the researchers, this particular SNP is responsible for up to 1.5 percent of the difference in QT interval, meaning that other genes, missed in this study, certainly contribute to QT length. Now that rese...

'Virus chip' detects new virus in prostate tumors

...one of 66 tumors from men with at least one normal copy of the gene. The researchers don't know if the virus is unique to prostate tumors because this is the first tumor type they have studied using virus chip technology. As with most scientific discoveries, the identification of this virus in human pros...

Patterns in genome organization may partially explain how microbial cells work

...omes." A bacterial cell usually operates with one copy of its genome. Until 2002, there had been no way to determine if a particular gene or area of the chromosome was segregated in any particular way inside the cell. New techniques that attach fluorescent "reporter" markers to predetermined spots on chr...

Waking a sleeping virus

... between the two ZEBRA molecules revealed that one copy of ZEBRA plugs a large side chain into a deep pocket in the other. "This is an ideal type of structure to try to target with a drug," Petosa says. "If we can find a molecule to block access to the cavity, the copies wouldn't be able to bind to each o...

Aggression-related gene weakens brain's impulse control circuits

...ve more impact on males because they have only one copy of this X-chromosomal gene, while females have two copies, one of which will be of the H variant in most cases. Several previous studies had linked increased serotonin during development with violence and the L version of MAO-A. For example, a 2002...

Animals can change genes quickly to keep up with viral ingenuity

...lls of other organisms, using them as factories to copy themselves. Animals and plants have a number of different locks and codes that help to keep the viruses out, but viruses are capable of evolving new ways of breaking the codes extremely quickly. The new research shows that genes controlling a part of...

Less is more, gene study shows

...f Africans and African Americans have a functional copy of the gene. Interestingly, people who lack the gene are better able to resist sepsis than those who have a working copy. "This is another indication that loss of the gene would be good for the individual, but it doesn't show that the gene became a ...

Common enzyme is a key player in DNA repair

... striking result," Walker said. "Not only did DinB copy over the damaged G nucleotide, it was 10 to 15 tim...e. For example, they said, DinB cannot efficiently copy over a particularly bulky type of damage caused by a chemical found in charcoal-broiled steaks. Th...

Stanford/Packard scientist's data-mining technique strikes genetic gold

...ions of this data. Sometimes people seem to almost copy and paste their entire scientific paper into the text box. We need to clean up our annotations because now we're showing that they have value." Butte and Kohane favor using the existing Unified Medical Language System, which consists of more than 1 ...

Study shows that cells have a natural defense against HIV

...ucleic acid. Once inside a cell, the virus makes a copy of its genes in the form of DNA. This DNA copy ?known as cDNA ?then travels to the cell nucleus. There, it becomes inserted, or integrated, into th...

Zebra finches remember songs dad sang

...ntually, the young bird manages an almost complete copy of his parent's song that includes some improvised elements. Birdsong scientists use the word "tutor" to describe the bird whose song the young bird copies and remembers because they've found that a young songbird will form a memory of any adult's ...

Genome changes tracked during multiple myeloma initiation, progression and treatment

... a high-resolution and integrated analysis of gene copy number alterations and expression profiles of outcome-annotated MM clinical specimens. The researchers discovered a high level of molecular heterogeneity typified by many new recurrent amplifications and deletions that point to a large number of ye...

Gene variation increases SIDS risk in African Americans

...ts. One out of nine African Americans carries one copy of the common variant. One copy does not appear to increase risk for infants. "The common polymorphism alone does not cause SIDS,"...

Scientists discover new genetic subtypes of common blood cancer

...f differences. The goal was to identify recurrent copy number alterations ?hotspots on the chromosomes where genes were abnormally duplicated or lost across many different tumors. The CGH analysis netted a large number of areas showing such alterations in the myeloma cells from patients. Then the scient...

Nanopore method could revolutionize genome sequencing

... is necessary to chop the DNA into smaller pieces, copy the DNA and use multiple sequencing machines, which introduces additional sources of error." The study was funded by the National Science Foundation and by the National Human Genome Research Institute at the National Institutes of Health. The NIH...

UCR researchers design chip that can improve citrus varieties

...expressed in the tissue) from plant tissue, make a copy of these molecules with a chemical tag added, and then "wash" the chip with the RNA sample. If a gene is being expressed in the tissue, its corresponding RNA will be present and bind to the complementary DNA sequences on the chip. The locations of th...

Major obesity gene is 'lost in the shuffle'

...Alu elements," explains Nakayama. "We located one copy of a specific Alu element on either side of the ASIP gene. Our study shows that during the evolution of gibbons, these Alu elements lined up and recombined with each other, erasing approximately 100 kilobases of DNA that spanned the ASIP gene." ...

Scientists uncover rules for gene amplification

...tion event Gene amplification is the increase in copy number of a particular piece of DNA and is a hallmark of tumor cells. Amplified genomic segments are frequently manifested in one of two cytologically recognizable forms. Double minutes are extrachromosomal segments of amplified DNA. Homogeneously st...

New human retrovirus originated in mice

...n than did those cancers that still had one normal copy of the RNASEL gene. "This link between the virus and RNASEL is the second finding that is important and is firmly established in this study," noted Ganem. "We don't see the infection in people who don't have the RNASEL mutation, which suggests stron...

Silence of the amoebae

...rting a plasmid (a small loop of DNA) containing a copy of a specific part of that gene into the amoeba cell nucleus. Introducing the plasmid led to the modification of DNA "packing" proteins, causing the DNA-protein packages to become more tightly coiled ?something like a tangled telephone cord ?and caus...

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