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Tag: "copy" at biology news

Researchers pioneer new gene therapy technique using natural repair process

...-2R gene along with the enzyme. Given the correct copy as a template, the recombination event occurred at... and 11 percent of the cells tested had traded one copy of the mutant gene for the correct version. In addition, 6 percent to 7 percent of cells had traded ...

Leprosy genome tells story of human migrations, French researchers report in Science

...c sequences known to be dynamic -- to move around, copy themselves or disappear -- and thus most likely to reflect evolutionary change, but found strikingly little variation. Next, the researchers looked for mutations known as "single nucleotide polymorphisms" or "SNPs," which are substitutions of single...

Mosaic mouse technique offers a powerful new tool to study diseases and genetics

...osomes. If one of those chromosomes contains a bad copy (mutation) of a gene, the recombination event could cause an offspring to inherit two bad copies of the gene, which would result in a mutant cell. This process simultaneously activates the green fluorescent protein, which turns the mutant cell green....

Depression gene may weaken mood-regulating circuit

...c resonance imaging (MRI). Those with at least one copy of the short variant had less gray matter, neurons and their connections, in the amygdala-cingulate circuit than those with two copies of the long variant. Next, using functional magnetic resonance imaging (fMRI), the researchers monitored the brain...

Diabetic nerve therapy shows 'striking' results

... we do not inject a gene that produces a 'foreign' copy of a therapeutic protein. This is the normal approach and has problems from immunological side-effects. "Instead, we turn on the patient's own gene to produce a natural version of this therapeutically beneficial protein. The most significant advanta...

Big differences in duplicated DNA distinguish chimp and human genomes

...n our species. They likely started out as a single copy of a segment in an ancestral species of both chimp... species - the segment is deleted from the genome, copy by copy, over time. The researchers found that many of the species-specific duplications have also...

Bumblebees copy one another when contending with unfamiliar flowers

...s do not choose flowers entirely alone but instead copy the choices of other bees. The new findings suggest that bees adjust their behavior when dealing with flowers of unfamiliar plant species. The observations are reported in the June 21 issue of Current Biology in a new paper by Elli Leadbeater and La...

Sandia completes depleted uranium study

...th a number of targeted vehicles. ### For a full copy of the report, download the following pdf file from http://www.sandia.gov/news-center/news-releases/2005/def-nonprolif-sec/snl-dusand.pdf : "An Analysis of Uranium Dispersal and Health Effects Using a Gulf War Case Study" ...

Researchers track down cause of a disfiguring bone disorder

... Loots and her colleagues genetically engineered a copy of the DNA segment containing the gene and used it to generate mice with and without the 52,000-base-pair region missing in Van Buchem patients. The deleted region is located about 35,000 base pairs "downstream" from SOST on human chromosome 17. Whil...

Analysis of flower genes reveals the fate of an ancient gene duplication

...ion--a relatively uncommon event in which a single copy of a gene is transformed into two separate copies--is thought to play a key role in the evolution of new gene functions. Duplications are important because they effectively allow at least one of the gene copies to evolve while the (likely important) ...

Cultural norms not unique to human societies

...s, discovered they possess a natural motivation to copy their peers well into adulthood and say that altho...m the Pan-pipes. "This study demonstrates apes do copy members of their own species and they develop different traditions by doing so," said Dr. Horner. "I...

Study identifies gene in mice that may control risk-taking behavior in humans

...26.Olson and colleagues studied mice with a single copy of the neuroD2 gene and found they had an impaired...n mice with no neuroD2 gene. In mice with just one copy of neuroD2, researchers also found fewer nerve cells in the amygdala. Researchers conducted exper...

Gene loss accelerates aging

...ensive studies of mice that are born with only one copy of the gene. Still, these animals die at a young age. So to study p63 function in adults, Mills and her colleagues devised a sophisticated molecular genetic technique that enabled them to eliminate both copies of the gene from particular tissues--inc...

Sugar helps control cell division

...emoving the sugar from proteins causes the cell to copy its genetic material and make new nuclei, but to fail to divide in two. The end result is cells with more than one nucleus -- a situation fairly common in cancer cells. "Cells with more than one nucleus can survive, but they are dysregulated -- thin...

Weight control protein may yield antiobesity drugs

...y in animals, Rui said. Mice lacking a functional copy of the SH2-B gene were smaller at birth than normal mice. After 5 weeks of age, however, the mice began gaining weight rapidly and were about twice as heavy as normal littermates after several months, with at least a 2.8-fold increase in body fat con...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...proaches, muscle cells were able to assimilate and copy the genetic instructions for making mini-agrin. Once produced, the mini-agrin protein functionally took the place of the laminin alpha-2 protein by binding to the key proteins on either end, thus restoring the cell's outside scaffolding and reestabli...

Gene for immune deficiency syndromes found

... TACI mutations are dominant, people with even one copy of the mutation will be unable to mount a strong antibody response. "A test for TACI would allow for diagnosis of more children and their relatives," says Geha, senior author of the study and a professor of pediatrics at Harvard Medical School. "Man...

Protein amplification in melanoma is possible drug target

... TACI mutations are dominant, people with even one copy of the mutation will be unable to mount a strong antibody response. "A test for TACI would allow for diagnosis of more children and their relatives," says Geha, senior author of the study and a professor of pediatrics at Harvard Medical School. "Man...

Study findings offer potential new targets for antibiotics

...iotics ?the researchers first introduced a mutated copy of the ribosomal genes into E. coli cells and looked for those rare mutations that could interfere with cell growth. It was known from previous studies that such deleterious mutations occurred within critical regions of the ribosome. After identifyi...

DNA size a crucial factor in genetic mutations, study finds

...osine (C). A always pairs with T, and G with C. To copy itself, the DNA molecule unwinds and splits. Either strand is now a template to build a new DNA molecule. An enzyme-a protein that speeds the reaction, in this case the bacteria E. coli's DNA polymerase I-moves along the template and selects the corr...

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