Improved statistical tools reveal many linked loci
...actors, even though more than one genetic location contributes to the observed trait, such as blood pressure or cell growth. The new statistical method bypasses the previously overwhelming computations needed to puzzle together the myriad elements that influence gene expression throughout an entire genome. And ...Small worm yields big clue on muscle receptor action
...CR-16-containing receptor is present in muscle and contributes hugely to the synaptic current," said Richmond. "Now we can tag this receptor, see if it's localized at the synapse and start to mutagenize animals to figure out what makes that receptor stay or make it to the synapse," she added. Richmond said the...Researchers develop promising new gene network analysis method
...use breast, colon and other types of cancer. C-Myc contributes to more than 70,000 deaths in the United States each year. Once the c-Myc switch is thrown, thousands of other genes start pumping out proteins or switching on other genes, which activates still more genes. One way to study this web of connections w......h is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis. The article by Nakamura et al., "Expression profiles and functional analyses of Wnt-related genes in human joint disorders," appears in the July issue of The American Journal of ...Evolution of taste receptor may have shaped human sensitivity to toxic compounds
...sion into new environments. More broadly, the work contributes to the debate on the mechanisms governing the evolution of chemical sensory perception and on the role of diet as a selective force in human evolution. ...New clue to cocaine addicts' quirky behavior
... on the brain circuitry mechanism whose disruption contributes to the impulsive behavior seen in users of cocaine as well as other psychostimulant drugs. The same circuitry has been implicated in such disorders as schizophrenia, depression, and post-traumatic stress disorder, wrote the researchers. Yukiori Goto...Missing Receptor Molecule Causes Tumor Growth
A missing receptor molecule contributes to the growth of tumors in human ovaries. This surprisingly evident connection has now been proven by a team at the Medical University of Vienna, who published their data in the science journal Molecular Cancer Research. The team, who is supported by...Nanoparticles carry cancer-killing drugs into tumor cells
A missing receptor molecule contributes to the growth of tumors in human ovaries. This surprisingly evident connection has now been proven by a team at the Medical University of Vienna, who published their data in the science journal Molecular Cancer Research. The team, who is supported by...Gap-climbing fruit flies reveal components of goal-driven behaviors
... into the gap, primarily by little hind-leg steps, contributes the most to gap-crossing. Auxiliary actions of the middle legs keep the body close to a horizontal position and help in reaching the other side. In the last step, the front legs stretch as much as possible to grasp the other side. In some ways, the ...Investigating 'brain shrinkage' in alcoholics
...rt of the dynamic course of alcoholism that likely contributes to its maintenance. In the symposium, [we presented] data showing that alcoholics can surmount these impairments in decision making and evaluation of rewards and punishments to achieve multi-year sobriety." Harper praised the symposium's multi-disci...Malfunctioning bone marrow cells sabotage nerve cells in diabetes
...hese findings, we speculate that a similar process contributes to some, if not all, of the other chronic complications of diabetes, and we look forward to pursuing this possibility. Discovering an underlying cause of diabetic neuropathy may enable us to design treatment strategies to prevent this complication in...Study shows eutrophic lakes may not recover for a millennium
...shwater reservoirs to soupy, weed-choked pools. It contributes to oxygen depletion, which leads to fish kills, and can stimulate the growth of toxic algae. According to the study, industrial agriculture, with its reliance on phosphorus-rich fertilizers, is the primary source of much of the excess nutrients resp...AIDS expert says global strategy needed to combat feminization of HIV/AIDS
...er-to-child transmission during childbirth further contributes to the spread of the disease. Women are particularly vulnerable to such cultural factors as their relative lack of power in sexual relationships, widespread poverty, policies that deny women an education and tolerance of violence against women. The...Lands surface change on Alaska tundra creating longer, warmer summers in Arctic
...n is absorbed by the land surface more readily and contributes to heating, thus accelerating the melting of snow and allowing for more plant growth. Over time, as the permafrost begins to melt, ancient organic matter that has been frozen for thousands of years is exposed, potentially adding more carbon dioxide t...One bacteria stops another on contact
...t is possible that the newly discovered CDI system contributes to this process. "By studying the CDI system, we hope to understand more about how bacteria interact with each other and with their hosts, and how these interactions contribute to disease," said Aoki. The findings may have repercussions outside of ...Once given 'no respect,' cells' tiny RNAS take driver's seat
...n many human cancer cells, although exactly how it contributes to cancer is unclear. Given Myc's regulatory role and its involvement in cancer, the Hopkins researchers tested human cells to see whether changes in the amount of Myc affected levels of any of the more than 200 known microRNAs. Through these experi...Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds
... that the presence of multiple queens "undoubtedly contributes to colony longevity." Niche construction "The cultivation of devil's gardens by ants is an excellent example of niche construction," Frederickson says. "By killing plants of other species, the ant promotes the growth and establishment of D. hirsu...After the yeast is gone bacteria continue to develop flavor of sparkling wine
...hemical changes take place due to cell lysis which contributes to the sensory characteristics of Cava. The researchers isolated 617 microbial strains from two Cavas, after 9 to 17 months of bottling. No yeasts were isolated after 10 months of bottling. Gram-negative and Gram-positive bacteria were isolated from...Scientists use gene transfer technology and common virus to block neuropathic pain in animals
...wn that decreased GABA activity in the spinal cord contributes to the development of neuropathic pain, according to Fink. Physicians have drugs that block neural transmission by mimicking the actions of inhibitory agents like GABA, but it's difficult to give these drugs in adequate doses, because the same drug ...Scientists use gene transfer technology and common virus to block neuropathic pain
...wn that decreased GABA activity in the spinal cord contributes to the development of neuropathic pain, according to Fink. Physicians have drugs that block neural transmission by mimicking the actions of inhibitory agents like GABA, but it's difficult to give these drugs in adequate doses, because the same drug ...