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Genetic roots of bipolar disorder revealed by first genome-wide study of illness

...ll function could lead to explanations of how they contribute to the condition and how it might be better prevented or treated. "Treatments that target just a few of these genes or the proteins they make could yield substantial benefits for patients. Lithium is still the primary treatment for bipolar disord...

Gene mutation linked to cognition is found only in humans

...orm and the weakening of the constitutive splicing contribute to the splicing pattern changes during primate evolution, suggesting a multi-step process eventually leading to the origin of the type II form in human," the authors state. They note that further studies should probe the biological function of typ...

Risk of lymphoma increases with hepatitis C virus infection

...the causes of lymphoma, establishing which factors contribute to the disease is the first step in finding ways to reduce its incidence and lessen mortality." HCV causes hepatitis, which is an inflammation of the liver. The HCV virus is carried through the blood and is passed from person to person through t...

Molecule that destroys bone also protects it, new research shows

... "Developing knowledge about the molecules that contribute to host defense versus pathology is very important for gaining a fundamental understanding of the immune system," Gaffen said, "but also because the consequences of therapies that target these cytokines need to be understood." ...

UCLA AIDS Institute researchers find a peptide that encourages HIV infection

...least, agents that enhance retroviral uptake could contribute to an emerging field of medicine." "So many people have tried to deliver genes into different kinds of cells," said study co-author Shen Pang, adjunct associate professor at the UCLA School of Dentistry and a member of the UCLA AIDS Institute. "I...

DOE JGI sets 'gold standard' for metagenomic data analysis

...ods publication, Mavrommatis has invited others to contribute new methods as they arise to continue to update the server and sustain the value of the system. This is also facilitated through a server called "Fames," available at the DOE JGI ( http://fames.jgi-psf.org/ ) where the community of researchers can ch...

Effect on breast tumors of DNA alternations in 3 genes described

...oming clear that other changes in the DNA may also contribute to the development of cancer." The researchers analyzed methylation status in three genes, known as E-cadherin, p16 and retinoic acid B2 receptor (RAR-B2), using tissue samples from 887 breast cancers. The samples were taken from women 35-79 year...

Fast and slow -- How the spinal cord controls the speed of movement

...hat a neurotransmitter released by brain cells may contribute to activating a system of nerves and muscles that allow for faster movement. They suspect that damage to these brain cells may disrupt the release of dopamine, further complicating free movement. Fetcho and his group are building a transgenic line of...

Revealing the machinery underlying the 'plastic' juvenile brain

...y, on the cell membrane, and intracellularly—might contribute to the developmental downregulation of plasticity occurring in coincidence with the closure of the critical period." ...

Uniform language for describing genes of pathogenic and beneficial microbes

... set up in a way that allows all users to actively contribute to the ongoing refinement of the terms. When a scientist submits a new term to PAMGO it enables the entire community to participate in synthesizing a common understanding of how microbes associate with hosts. This is a tremendous open-source resourc...

NIDA study identifies genes that might help some people abstain from smoking

...as playing roles in dependence to other drugs also contribute to nicotine dependence.? Genes that harbor variants that contribute to both success in quitting smoking and in vulnerability to become dependent on multiple substances ...

Whiteflies and plant viruses can help each other to speed up biological invasion

...tualism between the B whitefly and the viruses may contribute to the ability of the B whitefly to both invade and displace indigenous whiteflies, as well as causing disease pandemics of the viruses associated with this vector." The study also shows that infection of the whiteflies per se has limited effects ...

In young mice, gregariousness seems to reside in the genes

...t provides the first scientific insight that genes contribute to a novel form of natural reward - the pleasure of interacting with other juveniles. At a practical level, the new findings provide a foundation for understanding the motivations that underlie acts of altruism. Moreover, the work may also help influ...

Bones in motion: Brown scientists to create new 3-D X-ray system

...is high-resolution, high-speed imaging system will contribute to better treatments for knee, shoulder, wrist and back injuries and help scientists understand the evolution of complex movements, from the flight of birds to the leap of frogs. "This will be like having X-ray vision ?you'll be able to see throug...

Researchers develop marker that identifies energy-producing centers in nerve cells

...at extent does neuronal mitochondrial dysfunction contribute to Parkinson's or Alzheimer's. And, in a general way, we could look into whether there are changes in neuronal mitochondria as we age." Using advanced genetic techniques, the researchers have produced mice with fluorescent protein markers that id...

Genetic fingerprints identify brain tumors' origins

...to date. "We were hoping to identify genes that contribute to the formation of these tumors and find indicators that might help us predict which tumors will be relatively well-behaved and which will be more aggressive," Gutmann says. Previous studies have failed to produce any solid leads on the genetic alt...

Stanford-led study closes in on genes that may predispose some people to severe depression

...searchers sort out the environmental factors that contribute to depression, Levinson said. And knowing more about either genetic or environmental factors could help in developing more effective therapies to treat depression. "The treatments we have now are lifesavers for some people, but there are others ...

Gene found for rare disorder may reveal new pathway in mental retardation

...onal team of researchers identified two genes that contribute to Cornelia deLange syndrome (CdLS), a multisystem genetic disease that affects an estimated one in 10,000 children. The disease varies from milder to more severe forms, but classically includes mental retardation, impaired growth, heart defects, fee...

Major gene study uncovers secrets of leukemia

...e discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic ... "PAX5," "EBF" and "Ikaros" are likely to directly contribute to this block in normal lymphocyte differentiation, according to Downing. These genes encode protein...

Woman's Day and For Womens of Science

...abitants of mining regions. These activities alone contribute more than 10 percent of the mercury in Earth's atmosphere attributable to human activities today. Little is known about the behavior of mercury in marine ecosystems and methylmercury in marine fish, the ingestion of which is the primary way most pe...

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