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Tag: "contrast" at biology news

DNA Molecules Used To Assemble Nanoparticles

...ou can target a wide variety of molecules---drugs, contrast agents---to almost any cell," said Dr. James R. Ba...carrying many different kinds of molecules such as contrast agents and drugs, but the synthesis process is long and difficult, requiring months for each new mol...

Bioartificial kidney under study at MCG

...ese infections also can harm the kidneys. Even the contrast medium needed to study kidney function can be toxic. "I have seen healthy people on antibiotics for urinary tract infections develop renal failure; that's not uncommon, but it's most dreaded in the critically ill patient," Dr. Szerlip says. ...

Association of herpesvirus with lung disorder questioned

... Institute of Infectious Diseases in Tokyo, Japan, contrast with those in a much-publicized 2003 article published in The New England Journal of Medicine that reported the presence of the virus in similar samples of lung tissue from a similar number of patients. Both primary pulmonary hypertension and infe...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...genic mice bearingthe CPD photolyase transgene, in contrast to mice bearing the 6-4PPphotolyase transgene, showed superior resistance to the deleteriouseffects of UV irradiation. Not only could CPD photolyase transgenicanimals withstand doses of UV light that cause severe sunburn in normalmice, but they also ...

New, automated tool successfully classifies and relates proteins in unprecedented way

...roteins, suchas shape, texture, edge qualities and contrast against backgroundfeatures. Like fingerprints, a protein's SLFs act as a unique set ofidentifiers. Using a set of established SLFs, Murphy then developed acomputational strategy for automatically clustering, or grouping,proteins based on SLF similari...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...ge in cell fate and amplify it,acting as a sort of contrast enhancement mechanism in cell fatedetermination. Notch is activated bya protease that is present ubiquitously in the cell membrane. What haslong remained a mystery, however, is the question of how Notchreceptors that have not been activated by a lig...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...that regulates how many times a cell can divide.In contrast to normal cells, cancer cells divide continuously anduncontrollably. Scientists know that cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy c...

GATA: a graphic alignment tool for comparative sequence analysis

...that regulates how many times a cell can divide.In contrast to normal cells, cancer cells divide continuously anduncontrollably. Scientists know that cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy c...

Mouse brain tumors mimic those in human genetic disorder

...of tumorprogression," Gutmann says. "If we rely on contrast enhancement inchildren with NF1 optic pathway gliomas, we may be treating kids whodon't need to be treated. Using this mouse model, we hope to continueto hone in on more accurate diagnostic, prognostic and treatmentapproaches."Bajenaru ML, Garbow JR,...

Scientists document complex genomic events leading to the birth of new genes

...localization of one of the RGP-family isoforms. In contrast to RanBP2, which is found exclusively at the nuclear envelope, this RGP-family protein was detected in discrete cytoplasmic locations, thereby confirming its functional divergence from RanBP2. Identifying and characterizing genes that are responsibl...

New research indicates a 'troubled' greenhouse is brewing

...e warm, but this new information confirms that the contrast between the rainy season and the dry season will increase dramatically," says Greg Retallack, whose study indicating that a troubled greenhouse is brewing is published in the April issue of the journal Geology. In this case, the word "troubled" refe...

New methods of gene delivery using lasers

...d microscopes. The method is very powerful, and in contrast to other methods the team can select individual cells to be treated at will under the microscope. The new technique involves the violet laser being focused onto cell membranes for a fraction of a second ?this causes the membrane to open up, allowing...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...ientists have "programmed" cells to make their own contrast agents, enabling unprecedented high-resolution, de...we can now enable living cells to change their MRI contrast via genetic instructions." "The new imaging method is a platform technology that can be adapted for...

Researchers rein in regulatory RNAs

...enerated multiple transcripts of various sizes, in contrast to a single transcript that is expected under the traditional one gene-one transcript model. Furthermore, the SATs tended to be poly(A)-negative and enriched in the nucleus, which strongly suggests a functional role for these transcripts in gene regu...

New drug shows promise as powerful anticancer agent

...Studies examining normal human cells show that, in contrast to tumor cells, they are not influenced by ON01910. The authors suggest that because ON01910 is highly effective in combination with other chemotherapies and appears to be nontoxic, it may be beneficial for treatment of some advanced cancers that ar...

Nanoparticles offer new hope for detection and treatment

...out 100,000 molecules of the metal used to provide contrast in MRI images. This creates a high density of contrast agent, and when the particles bind to a specific area, that site glows brightly in MRI scans. In th...

Decoding the logic of olfaction

...olfactory cortex by Buck's group indicated that in contrast to the straightforward mapping of inputs from odor...fic locations in the cortex, " said Buck. In sharp contrast to the olfactory bulb, where signals from different receptors are segregated, inputs from different ...

Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer

...olfactory cortex by Buck's group indicated that in contrast to the straightforward mapping of inputs from odor...fic locations in the cortex, " said Buck. In sharp contrast to the olfactory bulb, where signals from different receptors are segregated, inputs from different ...

The biggest family tree ever

...cover through traditional genealogical methods. In contrast to written historical records that can be lost or oral histories that can fall into disuse, the information stored in people's genes persists. Cusanovich had his own DNA analyzed, which helped him trace his family to a time "when the crusaders were ...

Gene keeps neural cells on correct developmental path

...toria Lunyak, a research associate in his lab. In contrast to the tight packaging of neural genes in other cells, REST keeps the chromatin in embryonic stem and precursor neurons open and poised for gene activity. "REST keeps the brake on lightly until a trigger tells embryonic stem cells it's time to make ...

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