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Tag: "condition" at biology news

Does manganese inhaled from the shower represent a public health threat?

...oordination disabilities, behavioral changes and a condition that is similar to Parkinson's disease. Children, pregnant women, the elderly, and patients with liver disease are at highest risk from manganese toxicity. Some of these groups have developed manganese poisoning even at fairly low doses in their wat...

Research casts doubt on circulating stem cells

...have had to bring a significant improvement to the condition of the muscle." The next step was to find out whether the stem cell nuclei were actually producing muscle proteins. Here, the results were negative: "If at all, very few nuclei produced dystrophin ?in any case, far too few to achieve any improvement ...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...es a possible risk of immune system suppression, a condition that could leave patients vulnerable to infections or other diseases. "But our studies show that though many dendritic cells were destroyed, some still remained," he said. Their tests also revealed that mice infected with a potent bacterium survive...

Gene therapy works in mice to prevent blindness that strikes boys

...n the retina. In terms of disease development, the condition in the mice was roughly equivalent to retinoschisis in a 10-year-old boy. Six months later, researchers looked at the interior of the eyes with a laser ophthalmoscope and found cyst formation was clearly evident in the untreated eyes, but the treate...

Building a better mouse model of lung cancer: FHIT counts

...ns whose VHL gene is lost or mutated suffer from a condition called Von-Hippel Lindau disease, an inherited disorder characterized by abnormal blood vessel growth in the eyes, brain, spinal cord, adrenal gland and other parts of the body. The scientists exposed mice deficient in both genes to a second carcino...

'Nanospheres' that block pain of sensitive teeth

... Sensitive teeth or 'dental hypersensitivity' is a condition that arises when the dentine of the tooth is expos...tly reduced. Currently, the only way to treat this condition is through good dental hygiene - using special toothpastes and fluorine mouthwashes which encourage ...

A little telomerase isn't enough

...telomerase doesn't lengthen them right away." The condition of the mice is virtually identical to the human disease dyskeratosis congenita, which has already been linked to mutations in telomerase that hinder the protein's telomere-maintaining activity. In both mice and people with the condition, stem cells i...

Pillows - a hot bed of fungal spores

...is most likely to cause disease; and the resulting condition Aspergillosis has become the leading infectious cause of death in leukaemia and bone marrow transplant patients. Fungi also exacerbate asthma in adults. The researchers dissected both feather and synthetic samples and identified several thousand spo...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...t the disease." Sickle cell disease is a genetic condition that causes an abnormal type of hemoglobin to be made in red blood cells. The aggregation of hemoglobin S inside red cells interferes with the body's blood cells' ability to flow through small blood vessels, depriving tissues of adequate oxygen suppl...

Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds

...althy copy of the gene dystrophin into mice with a condition that mimics muscular dystrophy. The dystrophin gene is mutated and as a result produces a defective protein in the roughly 20,000 people in the United States with the most common form of the disease. Using gene therapy to treat muscular dystrophy is...

Double trouble: Cells with duplicate genomes can trigger tumors

...riety of early human cancers and in a precancerous condition called Barrett's esophagus. In addition to the extra chromosomes, the "double value" or "tetraploid" cells also duplicate a cell structure called the centrosome that plays a role in maintaining a stable genome. The extra centrosomes may be at the roo...

Marine conservation organizations team up to conduct Indonesia coral reefs assessment

...hile they record observations regarding ecological condition on an underwater slate. The Reef Check survey is the only standard method used to survey the world's reefs. Initial surveys in the region conducted by Reef Check and other marine conservation organizations have revealed varying levels of reef damage,...

Stroke treatment a step closer after trial

...spital in Salford, added: "Stroke is a devastating condition that affects many thousand of people so the development of any effective treatment would have enormous benefits to the patients I see and to their families. "We still have quite a long way to go before we can be sure if this will be an effective tre...

Synthetic Protein Eases Arthritis Symptoms in Mice

...and and, perhaps, to treat rheumatoid arthritis, a condition that causes suffering in more than two million Americans,?says NIAID Director Anthony S. Fauci, M.D. Investigators from NIAID’s Laboratory of Immunology, led by Michael Lenardo, M.D., published their findings in the October issue of Nature Medicine,...

Limiting the damage in stroke

...d a sophisticated method of creating a stroke-like condition in mice, a model that can be used to investigate new therapies. What would happen if the activity of NF-kB in neurons were blocked after a stroke? To test this, genetic mouse models were required. The group of Manolis Pasparakis at EMBL's Mouse Biol...

Image of myosin-actin interaction revealed in cover story of Molecular Cell

...hypertrophic cardiomyopathy (FHC), an undetectable condition resulting in death by sudden cardiac arrest in otherwise healthy young adults. Contributors to this work include: Niels Volkmann, Ph.D., assistant professor and first author on this publication, Dorit Hanein, Ph.D., associate professor, Hong-Jun Liu...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

...lls transplanted in the striatum of animals with a condition like Parkinson's showed not only that a critical drug could be delivered to the right place, but that the drug was delivered in a way that promoted its therapeutic potential. The researchers reported new nerve fiber growth in the striatum and the tra...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...fering chronic ischemic coronary artery disease, a condition in which one or more of the primary arteries supplying blood flow to the heart are clogged. The study will include patients who are not candidates for angioplasty, stent placement or coronary artery bypass grafting (CABG). Dale Adler, M.D., vice ch...

MUHC investigators search for the root of sexual pain in women

...tician/epidemiologists, to root-out the cause of a condition experienced recurrently by at least 15% of Canadian women. The research team will focus specifically on two main areas of study: dyspareunia (pain during sexual intercourse) and vaginismus (vaginal spasm preventing intercourse). These conditions, wh...

One small step means giant leap for spinal cord research

... helps to increase walking function in those whose condition is not expected to improve. U of T researchers have found that functional electrical stimulation (FES), a process that sends controlled bursts of electricity through the skin and into muscles, can help patients improve their step frequency, stride ...

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