Cellular Defects in Premature Aging Disease are Reversible
...t stiffness, osteoporosis, and heart problems. The condition is fatal, with heart disease being the leading killer, and affected children usually die before they reach their late teens. Less than two years ago, NIH-led researchers discovered that the genetic basis for HGPS is a single mutation in the gene enc...Disease progression model of pancreatic cancer developed by Penn researchers
...r that fully imitates the progression of the human condition will likely open many new doors in understanding this debilitating disease. "With a model that can generate the full spectrum of disease, from preinvasive to invasive and metastastic lesions, we can begin to tease out the events that are linked to th...Man-made wetland's effectiveness similar to natural marsh
... miles of the Gulf of Mexico into a "dead zone," a condition known as hypoxia. Hypoxia happens when excess nutrients, such as nitrates and phosphorus, accumulate in a body of water and cause excessive growth of algae and algal blooms. These blooms thrive on the nutrients and deplete the water of nearly all of......t, and patients are often not identified until the condition is quite advanced. Agilent's new microarray techniques in comparative genomic hybridization (CGH) will allow researchers to rapidly and reliably identify genetic changes in tumorous cells. It is believed that specific genetic changes may accompany t...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...m global warming, it will not recover its previous condition simply through an equal but opposite change in temperature. That is, much like a financial market that takes much longer to recover than to crash, an ecosystem that is perturbed into an irreversible shift (e.g., by overfishing) may never be the same ...Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
...cule could be tested in an electrolyte solution, a condition that past experiments didn’t attempt because of the problem of interaction between the solution and the electrodes. “Almost everything we know about charge transfer in molecules is based on measurements made with the molecules suspended in solution,...Too much water may be as dangerous as too little during long-distance athletic events
...mselves at jeopardy for developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in physical symptoms such as lethargy, disorientation, seizures and even respiratory distress. In a perspectives article in the current issue of The New England Journal of Medicine, Dr. B...Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage
...mselves at jeopardy for developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in physical symptoms such as lethargy, disorientation, seizures and even respiratory distress. In a perspectives article in the current issue of The New England Journal of Medicine, Dr. B......mselves at jeopardy for developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in physical symptoms such as lethargy, disorientation, seizures and even respiratory distress. In a perspectives article in the current issue of The New England Journal of Medicine, Dr. B...15-year hunt finds cause of pseudothalidomide syndrome
...ed members and 33 unaffected members) and tied the condition to one of 6 genes. Then, the international team compared the human sequence of the genes to those from chimpanzee, mouse, rat, chicken and zebrafish, and to the gene sequences of the affected family members. One segment of a gene called ESCO2 that w...UCLA study assesses cost-effectiveness of Hepatitis B drugs
...y society and many insurers for treating a chronic condition like hepatitis B is roughly $50,000 or less per quality-adjusted life-year gained, which is a standard measure used in assessing the outcome of health care procedures or services. According to Kanwal, the study showed that only two strategies fell w...Disabling gene defuses rheumatoid arthritis in mice
...Rheumatoid arthritis has long been recognized as a condition that involves defensive cells from the body's immu...ound that knocking out Foxj1 produced a lupus-like condition in mice. Foxj1 and Foxo3a are thought to play similar roles in immune T cells. To get a better sens...Function of new cancer genes discovered
...indromatosis. Patients with the very rare genetic condition cylindromatosis develop a lot of benign tumours on the skin. These tumours mainly occur on the head where they can cause serious malformations. People with this disease have a mutated form of the protein CYLD. Nijman and his colleagues used genetic ...Enzyme's newly discovered role may make it target for arthritis treatment
... an inflammation," Pham explains. "This leads to a condition similar to rheumatoid arthritis in the mice." Three years ago, Pham's lab published results showing that mice deficient in cathepsin G and other closely related proteases failed to develop arthritis after the injections. This led them to look for th...Study finds adult stem cells can replicate
... an inflammation," Pham explains. "This leads to a condition similar to rheumatoid arthritis in the mice." Three years ago, Pham's lab published results showing that mice deficient in cathepsin G and other closely related proteases failed to develop arthritis after the injections. This led them to look for th...Diabetic nerve therapy shows 'striking' results
...and digestive tract. The incidence of diabetes, a condition in which the amount of glucose in the blood is too high, is increasing dramatically, with the World Health Organisation estimating that some 300 million people worldwide could be affected by 2025. The causes of diabetic neuropathy are not fully unde...Bacteria feed on smelly breath (and feet)
...ng from progressive gum disease (periodontitis), a condition which is often associated with smelly breath. However, no assessment was made of the levels of methylotrophic bacteria present, low levels of which may be associated with bad breath. In a previous paper, Dr Wood et al found that the foot is also a s...Study shows humans have ability to track odors, much like bloodhounds
...tory nerves and therefore couldn't smell at all, a condition known as anosmia. Normal subjects, 16 in all, were able to tell which nostril was receiving a squirt of scent, but anosmic volunteers could only localize the trigeminal odorants, Sobel said. This shows that humans are able to localize odors through ...Newly discovered genetic disease sheds light on body's water balance
...eviously shown to block the V2 receptor, causing a condition opposite to NSIAD called Nephrogenic Diabetes Insi...nfants so far have been identified with NSIAD, the condition may not be rare, according to Stephen Rosenthal, MD, professor of pediatric endocrinology and co-lea...