New light microscope sharpens scientists' focus
... tiny percentage of the labeled molecules. The concept struck them as so obvious, in fact, that they susp...hree groups were in close cooperation to bring the concept to reality. By October 2005, the prototype was ready for testing, thanks in part to equipment res...T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
... of Pittsburgh researchers. In essence, that's the concept behind the development of a novel therapeutic vaccine loaded with a patient's own souped up dendritic cells, which have been galvanized to rally other cells of the immune system in fighting the virus unique to that individual. At the XVI Internatio...Protein connections: A network to understand disease
...connected people around the world. Now, the same concept provides clues to unraveling the mystery of how di...cause of degeneration of specific nerve cells. The concept can be used to study many diseases. "We study degenerative diseases," said Dr. Huda Zoghbi, profes...Bacteria can help predict ocean change
... ocean change. Scientists have long endorsed the concept of a unique biological niche for most animals and plants ?a shark, for example, has a different role than a dolphin. Bacteria instead have been relegated to an also-ran world of "functional redundancy" in which few species are considered unique, sa...UF scientists restore sight to chickens with blinding disease
...red vision to blind Briard dogs. "This is proof of concept using a unique vector, animal model and approach. One would hope this could happen in a human." Semple-Rowland, a College of Medicine faculty member, has worked since 1986 to first discover the malfunctioning gene, known as GC1, and then to develop ...DNA: Bacteria's survival ration
...s a nutrient may be a widespread phenomenon." The concept of nutritional competence could have applications to medical research, as the DNA from dead cells in the human body may be sustaining harmful bacteria. One of the pathogens implicated in cystic fibrosis is suspected of feeding on DNA in lung tissue,...First human trial of antibacterial contact lens
...ested antibiofilm compounds and generated proof of concept data in a broad range of product categories in the medical, industrial and consumer fields. ...New protein target may advance design of HIV and cancer drugs
...ponsible for the spread of cancer. By applying the concept to development of anticancer drugs, the researchers hope to design more specific clinical agents with reduced side effects compared to the very useful, but toxic, cisplatin and congeners. ...Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic
...are research platform, a science appliance cluster concept invented at Los Alamos in the Computer and Computational Science Division. Los Alamos has four science appliance clusters in use at this time for a variety of projects across the full range of Laboratory mission areas. ...A case of mistaken molecular identity
... said. "This is important, because it enlarges the concept of molecular mimicry in Chagas disease." Rhodopsin and beta1-adrenergic receptors in heart cells belong to the same class of molecules, a subfamily of the G-protein-coupled receptors, he pointed out. Paveto, an independent researcher at INGEBI--an ...Tandem transcripts team together
...a certain way, this phenomenon challenges our very concept of a gene," points out Guigó. "The 'one gene, one protein' rule has been fundamental to molecular biology. However, as we deepen our understanding of the eukaryotic genome, a picture emerges that challenges this paradigm ?not a picture in which the...Genome changes tracked during multiple myeloma initiation, progression and treatment
...ailed view of the MM genome is consistent with the concept of widespread changes in the expression of genes with cancer activity in the pathogenesis of MM, a concept with therapeutic and diagnostic implication for MM in particular and cancer in general," explains Dr...Mayo Clinic researchers challenge sepsis theory
...ls. The Mayo researchers challenge that long-held concept with a new theory in an opinion piece in the curre...nceptual shift about sepsis. "The problem with the concept of sepsis, and what provoked some of our interest, is that it has been known for 10 years that when ...USC, Rice to develop bacteria-powered fuel cells
... the USC and Rice research team hopes to prove its concept valid within five years by producing a self-propelled prototype. At Rice, geochemist Andreas Lüttge will spearhead the team's efforts to understand how the bacteria Shewanella oneidensis attach to and interact with anode surfaces inside the fuel cel...New compound stops brain cell degeneration in Alzheimer's disease
...e diseases in general because it provides proof of concept that targeting over-production of cytokines by activated glia is a viable approach that has the potential to modulate disease onset and progression, the researchers said. Decline of cognitive functions linked to the part of the brain called the hipp...Cancer cells suppress large regions of DNA by a reversible process that can be tackled
...ion with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies. They have found large regions of DNA are 'switched off' in colon cancer. Lead researcher Associate Professor...Ernst Mayr's theory illustrated in genetic epidemiology studies
...ies contributed greatly to the refinement of May's concept of genetic revolution. Templeton said that his CAD studies in human founder populations reveal interactions between two important genes involved in high cholesterol, the Apolipoprotein E (APOE) gene and the Low density lipoprotein receptor (LDLR) ...Access to existing medical treatments could save more lives than spending to improve the treatments
...isely when they need them. Woolf illustrated the concept with an example of a theoretical disease that clai...suffer." The authors discuss the relevance of this concept at a time when the nation is struggling with the escalating costs of health care and unsatisfactory ...Researchers use 'trickery' to create immune response against melanoma
...Using prostate cancer as a model disease, proof of concept nanoscale targeted drug delivery vehicles were developed (1 nanometer = 0.000000001 meter), which can target prostate cancer cells with high specificity and efficiency. Once bound to prostate cancer cells, the nanoparticle/aptamer bioconjugates were ...Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
...Using prostate cancer as a model disease, proof of concept nanoscale targeted drug delivery vehicles were developed (1 nanometer = 0.000000001 meter), which can target prostate cancer cells with high specificity and efficiency. Once bound to prostate cancer cells, the nanoparticle/aptamer bioconjugates were ...