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Tag: "compounds" at biology news

New study reveals promising osteoporosis treatment

...uture research may also focus on using Mg/Zn/F-CaP compounds to repair fractures and periodontal bone defects. ...

MIT research holds promise for Huntington's treatment

...ooking for Huntington's treatments have focused on compounds that prevent or reverse the aggregation of hunting...the MIT and Harvard scientists decided to look for compounds that actually promote the formation of large inclusions. The highest concentration of protein inclu...

U-M researchers take new approach to defeating Gram-negative bugs

...arch leads to combination therapies, which include compounds that could duplicate the effect caused by the genetic mutation of bacteria together with low-dose antibiotics. "Bugs are very smart," Woodard said. "It's not a matter of if a bug will become antibiotic resistant, but when. We have to work hard to ge...

Novel virus entry mechanism could lead to new drugs against poxviruses

...olved, the researchers demonstrated that polyionic compounds can be used to treat poxvirus infections, even day...ed. Disrupting the outer membrane with polyanionic compounds exposes the virus, allowing antiviral antibodies to be more effective. The disruption of the outer m...

Creation of antibiotic in test tube holds promise for better antibiotics

.... Nisin is one of numerous members of a family of compounds called lantibiotics, all of which are candidates for bioengineering into new pharmaceuticals, van der Donk said. The key is learning more about the enzymes involved in their biosynthesis. "Our work, while not explaining everything, has brought us muc...

Heparin prepared synthetically could replace animal-derived drug

...ructure-activity relationship that may reveal lead compounds for new drug development. Researchers at MIT firs...solid phase synthesis as a tool for screening lead compounds with heparin-like structures for drug discovery, according to the researchers. The findings were pub...

Legume compounds may help cancer treatment

...CILR) has lodged a complete patent application for compounds to treat cancer. CILR researchers screened legum...iological activity and they identified a number of compounds which could potentially prevent the formation of a blood supply to tumours. Without an adequate bloo...

Free-radical busting antioxidants might not promote healthy hearts

...disease in humans. The protective effect of these compounds depended on the induction of a cellular enzyme called heme oxygenase-1 (HO-1). HO-1 is known to protect against atherosclerosis in animal models, although the mechanism is not completely clear. Not surprisingly, HO-1 was not induced by Vitamin E. Dr...

HIV vaccine takes different tack to boosting immune response

...a pathway that not only controls the production of compounds (cytokines) that stimulate inflammation but also plays a critical role in regulating the potency of anti-HIV immune response. Dendritic cells in which SOSC1 was switched off were able to induce an effective long-term memory immune response to HIV. "...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...cisplatin, are among the most effective classes of compounds in clinical use for the treatment of cancer. The principal function of cisplatin is to bind to DNA. Platinum drugs are the largest class of anti-cancer drugs in the clinic and the most important in terms of treatment. Cisplatin is a chemotherapy drug...

Salmonella bacteria use RNA to assess and adjust magnesium levels

...viously identified riboswitches respond to organic compounds such as nucleotides and sugars. The Salmonella riboswitch, reported in the April 7 issue of the journal Cell, responds to magnesium ions, key elements in the stability of cell membranes and reactants in an energy-making process that fuels most cells....

Pesticides in the nation's streams and ground water

... dieldrin, and chlordane--organochlorine pesticide compounds that were no longer in use when the study began--w...an and agricultural areas. Concentrations of these compounds in fish declined following reductions in their use during the 1960s and elimination of all uses in t...

Secrets of the sea yield stronger artificial bone

... span of several weeks, liberating antibiotics and compounds that stimulate bone growth. The idea is to place this dense hydroxyapatite-polymer composite in the body where new bone needs grow. Over time, as the polymer degrades, the scaffolding becomes more porous and the growth factor activates, prompting bo...

Study fishes out new role for prostaglandins

Prostaglandins ?the fat-derived compounds linked to pain, inflammation, reproduction and cancer ?can add another biological function to their extensive catalog. A new study by Vanderbilt researchers reveals that prostaglandins help choreograph the intricate cell movements during early embry...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...s. "There's a lot of interest in the use of these compounds in therapy and prevention," Harris noted. "It will be important for investigators to look at these compounds in prospective and retrospective studies to see if these results are consistent." "We're concerned a...

Albatross study shows regional differences in ocean contamination

...ological Applications. Mercury and organochlorine compounds such as PCBs (polychlorinated biphenyls), DDT, and related compounds persist in the environment for a long time and build up in the tissues of animals high on the food c...

Vegetables inhibit growth of prostate cancer in mice with human tumors

...ological Applications. Mercury and organochlorine compounds such as PCBs (polychlorinated biphenyls), DDT, and related compounds persist in the environment for a long time and build up in the tissues of animals high on the food c...

Biomarkers may hone anti-aging therapies

...contributes to aging and cancer, and for screening compounds that prevent or reverse the process, Sligh said. ...

Mystery solved: Gold's power against autoimmune diseases defined

Gold compounds have been used for the treatment of rheumatoid art...thritis. During their search through thousands of compounds they found that the known cancer drug, Cisplatin, a drug containing the metal platinum, directly str...

Genetically altered mice no longer like cocaine

...rmal mice. Gu said the next step is to screen for compounds that could produce the same effect that the genetic modifications did in this study. "We hope to find certain drugs that prevent cocaine from binding to transporters, but that still allow the transporter protein to carry the dopamine back to the neu...

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