Supercomputers to focus brains on AIDS dilemma
...sides, what the scientists have called "butterfly" compounds with "wings" extending to both the east and west. ...go on to prove experimentally the effectiveness of compounds in binding to different parts of the HIV integrase enzyme," said McCammon. Because of the great pro...Designing vaccines by computer
... modern bioscience generates and cut the number of compounds drug companies need to test when searching for new vaccines. Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at the Edward Jenner Institute for Vaccine Research are using a very simple concept to ...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...S Institute study has discovered that two chemical compounds may help the immune systems of HIV-infected person... David Geffen School of Medicine at UCLA. "The two compounds switched telomerase back on in the cells." In earlier research, the UCLA team showed that inserting...Molecular thermometers on skin cells detect heat and camphor
... great need for new therapeutics. Indeed, several compounds that are currently under investigation for alleviating chronic pain target the action of a protein called TRPV1 (VR1), which is similar to TRPV3. Molecular Thermometers TRPV3 and TRPV1 are both proteins that belong to a class of molecules known as ...To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
...halted in its tracks by subjecting the bacteria to compounds that block LexA. Interfering with this protein ren...lution of resistance is under the control of LexA, compounds that block the protein might prolong the potency of existing antibiotics. Evolution -- Its not Like...Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights
...oducts, they start putting out chemically unstable compounds such as nitric oxide and superoxide. Together, these compounds generate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's group showed ...Prescription Drug Patches Gaining Ground, Tackling New Therapies
...e capable of delivering sustained dosing of active compounds for several days in a smaller package. “The number of drug therapies being developed in patch form is expanding,?explains George Perros, Greystone Managing Director. “At the same time, improvements in patch esthetics and the success of existing presc...Remote control flies? Fly behavior controlled by laser light
...a and Miesenböck caged the ATP with other chemical compounds that could be removed by the laser light. Miesenböck says one of the most difficult parts of the experiment was deciding which particular nerve cells to target with the remote control system. "To ascertain that the system actually worked, it wasn't ...A hope for oil spill bioremediation
...al populations able to degrade polycyclic aromatic compounds such as phenanthrene or naphthalene, especially in those sites that had recently been restored after an important contamination episode. Authors concluded that, probably due to the contamination record of the past in that coast, indigenous population...Experiment station researchers to explore genome of disease-fighting fungus
...ay the genome sequencing work may uncover chemical compounds and beneficial genes useful in producing new human...choderma responsible for producing uncharacterized compounds that might be novel antibiotics." By sequencing the fungus, researchers say they will be able to de...Searching the depths of the straits of Florida for disease cures
...ry group hopes to add to its growing collection of compounds derived from marine organisms that continue to show promise in fighting various forms of cancer and other diseases. ...Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
The ability to select and develop compounds that act on specific cellular targets has just gai...esses. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic responses free of unwa...Major new UNC-based drinking water study suggests pregnancy fears may be overstated
...nalyzed the data to see what effects the byproduct compounds might have had on pregnancy loss (miscarriage). T...itz said. The new work did suggest that brominated compounds and total organic halides at normal-range levels in purified drinking water might modestly increase ...Natural tumor suppressor in body discovered by UCSD medical researchers
...professor of pharmacology. "Currently there are no compounds identified to directly stop Akt from causing cancer growth, once Akt signaling has been initiated." Scientists have known that Akt is critical in regulating cell growth and death, and that it is linked to some of the most common human cancers. Altho...Enzyme's newly discovered role may make it target for arthritis treatment
...ement of integrins, an important group of adhesion compounds on the surface of neutrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "Th...Study finds adult stem cells can replicate
...ement of integrins, an important group of adhesion compounds on the surface of neutrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "Th...Bacterial genome sheds light on synthesizing cancer-fighting compounds
...quirt, actually produces the desired patellamides, compounds that may one day be used in cancer treatment. Des...esearchers to synthesize the potentially important compounds in the lab using a so-called laboratory workhorse, the bacterium E. coli. Scientists from The Insti...Bacteria feed on smelly breath (and feet)
...ted bacteria which can grow on and 'mop up' smelly compounds in the mouth that are linked to bad breath. These smelly, highly reactive 'one-carbon' compounds are naturally produced from the breakdown of sulphur-containing amino acids in the mouth. Dr Ann Wo...Deep thinking: Scientists sequence a cold-loving marine microbe
...urated fatty acids that resist freezing, polyester compounds that offer extra energy reserves, protective solutes inside cells, and ordinary enzymes altered to function in chilly seawater. "Our goal was to compare C. psychrerythraea to a variety of bacteria that live at different optimal temperatures," remark...Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
...ughput equipment to screen for potential inhibitor compounds against the Dam enzyme. ...