Tag: "compound" at biology news

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...cular, someone who was a low-birth-weight baby can compound the risk of developing diabetes by becoming overweight," she added. "The stage is set in two ways: low insulin production coupled with resistance to insulin -- a double whammy." Other researchers involved in the Joslin study included co-authors Jose...

Controversial drug shown to act on brain protein to cut alcohol use

...ity ofCalifornia in San Diego identified a natural compound able to blockalcohol addiction in rodents. We can only hope that anti-alcoholismpatchs or gum will be available in a close future; it would help fix aproblem that we've been struggling with for ages. A naturally occurring hallucinogen advocated by so...

Anti-bacterial additive widespread in U.S. waterways

... essentially no idea of whatexactly happens to the compound after we flush it down the drain," saidthe study's lead author, Rolf U. Halden, PhD, PE, assistant professorin the School's Department of Environmental Health Sciences andfounding member of its Center for Water and Health.The nationwide assessment of...

Inflammatory molecules released by pollen trigger allergies

...s allergic reactions. They went on to identify the compound in the pollen extracts that caused the inhibitory ...ore sensitive to the effects of the pollen-derived compound than those from non-allergic individuals. A better understanding of these molecules and how they wor...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...antibiotic streptomycin -- also produces a natural compound called migrastatin, which appears to inhibit cell migration. Natural migrastatin's effect is relatively weak, but Dr. Huang suspected the molecule might be manipulated into something more potent. In collaboration with the laboratory of Dr. Samuel Da...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...the first steps of drug development by testing the compound in animal models of cancer. The research was supp...ists to believe they had discovered a new chemical compound with a unique biological function. When the scientists tested the compound's ability to inhibit Ras...

Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications

... different types of surfactant (a soluble chemical compound that reduces the surface tension between liquids). One surfactant acts as the template for mesoporous structure, while the other is used to limit the growth of the particles to nanometer dimensions. This method can be used to create a variety of nan...

Chemists identify key gene in development of type 1 diabetes

...t diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human studies prove the effectiveness of ISO-1, the compound or its derivatives could ultimately save lives, reduce health care costs and help prediabetic people...

Towards precise classification of cancers based on robust gene functional expression profiles

...t diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human studies prove the effectiveness of ISO-1, the compound or its derivatives could ultimately save lives, reduce health care costs and help prediabetic people...

Children's taste sensitivity and food choices influenced by taste gene

...tegorized three concentrations of a bitter-tasting compound (propylthiouracil; PROP) as tasting either "like water" or "bitter or yucky." Having a bitter-sensitive allele (P) on the TAS2R38 receptor gene predicted sensitivity to the bitter taste of PROP in both children and mothers. While 70% of children and...

Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy

... "What we're doing is testing a novel adjuvant, a compound that stimulates the immunological response to a vaccine, which is essentially tricking the immune system into thinking the vaccine is a bacterial infection," says lead author Dr. Daniel Speiser from the LICR Lausanne Branch. "The immune system mounts...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...s now demonstrate that lanosterol--an intermediate compound in the synthetic pathway--mediates feedback control over the rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availability of reductase, which functions early in the synthetic process, largely deter...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

...you don’t do a lot of other experiments to study a compound that later will be dropped ?that alone saves a lot of money.?/p> UF researchers say they will continue to apply the screening approach to other drugs in various situations and also will seek to develop better ways of determining how frequently an...

Products containing specific probes for detecting alternative splice forms protected

...patent, including drug discovery, diagnostics, and compound screenings for efficacy or toxicity as well as screening patients for potential efficacy of therapeutics. Alternative RNA Splicing is a critical step in the expression of most genes, which can result in the expression of several mRNAs encoding prote...

New drug shows promise as powerful anticancer agent

...this study have led to clinical evaluation of this compound in phase I clinical trials. Plk1 is a molecule th...tant to commonly used chemotherapeutic agents. The compound significantly inhibited a wide variety of human tumors, including liver, breast, and pancreatic canc...

Defenseless plants arm themselves with metals

... A molecule called salicylic acid - a common plant compound and the active ingredient in pharmaceuticals like aspirin and acne medications - governs this pathway. When faced with a fungus or bacteria, most plants turn up their production of salicylic acid, which then interacts with other molecules in the pla...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

... in multiple cell-signaling pathways. This means a compound may affect several different targets, rather than just one." In essence, Enigmols may act like a multi-drug combination therapy, the investigators speculate. Enigmols are also being tested in combination with other cancer chemotherapeutic drugs usi...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...ur aim was to determine what effects, if any, each compound had on mammary gene expression during at different ages," said Moral. "Our results showed that exposure to BPA changes the gene expression profile of mammary tissues as a function of age. That is, there was a significant increase in protein producti...

Activation of thermoreceptors mediates raw garlic's burning pungency

...be ascribed largely to the effects of a particular compound and its ability to activate specific protein therm.... The researchers went on to identify the sulfide compound allicin, an unstable chemical found in bruised, cut, or crushed garlic, as the chemical responsible ...

Could microbes solve Russia's chemical weapons conundrum?

... the mustard RM consists of derivatives of a toxic compound called 1,4-perhydrothiazine (PHT). Ermakova's research team grew P putida in cultures containing mustard RM. They then moni-tored the levels of PHT derivatives in the cultures until the bacteria stopped growing, using monoethanolamine (MEA) and ethy...

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