Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
...bilities or changed existing ones. Pharmaceutical companies have also not had the luxury of protein-interaction databases. They have routinely identified promising new drugs based on trial-and-error screenings of those molecules' ability to completely disable target proteins. Ideker said protein interaction i...New Mixing Method for Microchip-Sized Labs
...st CancerSymposium meeting. “At least 20 different companies have recognized theimportance of the pathway in breast cancer and are trying to developdrugs that target it.?In the future, breast cancer tissue samples fromnewly diagnosed patients can be tested for their specific PI3K pathwayabnormality in order to...Newly Discovered Compound Blocks Known Cancer-Causing Protein
...hway works. This accomplishment led pharmaceutical companies to test compounds that block another key player in the pathway, a protein called farnesyltransferase. Blocking this protein inhibits Ras' ability to send growth-promoting signals inside cells. Several such compounds have shown promise in treating leu...Genetic Variation Visualization - From EMBL
...st CancerSymposium meeting. “At least 20 different companies have recognized theimportance of the pathway in breast cancer and are trying to developdrugs that target it.?In the future, breast cancer tissue samples fromnewly diagnosed patients can be tested for their specific PI3K pathwayabnormality in order to...Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway
...st CancerSymposium meeting. “At least 20 different companies have recognized theimportance of the pathway in breast cancer and are trying to developdrugs that target it.?In the future, breast cancer tissue samples fromnewly diagnosed patients can be tested for their specific PI3K pathwayabnormality in order to...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
...ed tools have been refined and are now marketed by companies for general structural biology applications. As the PSI pilot centers have put automated structure determination pipelines in place, the number of protein structures they have solved has increased significantly. In the second, third, and fourth year...Development of portable infectious disease detector
...ery process.Fifteen years ago a number of start-up companies were created to makethe goal of creating a "lab-on... inventors had expected and the products thatthese companies have created thus far have been too expensive for thepoint-of-care diagnostics market.For their home...Learning to fight an adversary that won't stay down
...nadian Bacterial Diseases Network. "Pharmaceutical companies and other researchers have put hundreds of million...s are evolving genetically, and the pharmaceutical companies are evolving chemically; the two don't match," says Dr. Davies, adding that doctors who deal with mi...Finding Cures For Tropical Diseases: Is Open Source An Answer?
...nt incentiveshave driven commercial pharmaceutical companies to make Western healthcare the envy of the world, the commercial model only works ifcompanies can sell enough patented products to cover their R&Dcosts and produce profits for shareholders. The model thus fails in thedeveloping world, where few p...Computers to be used to find blueprint for new influenza drug
... April on a project that could help pharmaceutical companies develop a better drug that could be taken by peopl...r diseases. It will then be for the pharmaceutical companies to take our blueprint and turn it into a drug.?/p> Professor Williams said that his work is a mo...Male circumcision reduces risk of HIV transmission from women to men
...tween1993 and 1997, 745 male employees of trucking companies based inMombasa, Kenya were followed for the study. Initially they wereevaluated for circumcision status and HIV-negativity. Over the lengthof the study the men were asked to give information concerning thenumber of sexual encounters with three diffe......ated requests to the pharmaceutical companies. The companies responded to 37 out of 88 requests for data-on-file, but more than half of the responses indicated that the information would not be provided due to company policy or because it was proprietary. "We found that almost one-third of the pharmaceutical ...