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Tag: "comes" at biology news

Research links protein to breast-cancer migration

...in the body." News of the scientific breakthrough comes as the University announced Breast Cancer Campaign funding for two other research projects worth nearly £300,000. Dr. Andrew Gilmore, also in the Faculty of Life Sciences, has been awarded a grant of £146,000 to examine in more detail a process call...

Mapping the protein world

...NIH). The grant, which will run over four years, comes at a perfect time. "More than 1,000 research laboratories from over 50 countries are holding ARP/wARP licenses and by June this year our paper that described the key innovative feature of ARP/wARP in Nature Structural Biology in 1999 has reached the ...

Pathway toward gene silencing described in plants

...e RNA into small interfering RNAs (siRNAs). Along comes ARGONAUTE4 (AGO4), which grabs hold of the siRNAs while also binding to NRPD1b, the largest subunit of an alternative form of RNA Polymerase IV, Pol IVb. The AGO4-siRNA-NRPD1b complex is then thought to leave the nucleolus, acquire the second-largest...

When it comes to gene transcription, random pauses aren’t quite so random, study finds

...fic sites along the DNA double helix. This finding comes on the heels of the team's 2003 discovery that RNAP enzymes routinely make thousands of brief stops ("ubiquitous pauses") when carrying out the vital task of transcribing genetic information from DNA to RNA--a process called transcription. "Transcr...

Basic work on E. coli identifies two new keys to regulation of bacterial gene expression

...pression both in bacteria and in higher life forms comes from work performed originally on this model organism." The strain that Gourse works with is one of the most well-studied species in biology and has important ties to the UW-Madison. In his most recent study, Gourse investigated the interaction bet...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

...on. If the drug therapy is discontinued, the virus comes roaring back. Dr. Rinaldo and others have hypothesized that this is because the drug therapy does not completely restore CD8 cell immunity to the virus. So, in trying to figure a way to activate the CD8 cells to more efficiently control HIV, the rese...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...positively or negatively charged liposomes when it comes to binding with and penetrating cells. The next step for the FAK siRNA-DOPC liposome is toxicity testing. "So far it appears to be very well-tolerated," Sood says. "We hope to develop this approach for clinical use in the future." In addition t...

Study reveals details of mussels' tenacious bonds

When it comes to sticking power, marine mussels are hard to beat. They can adhere to virtually all inorganic and organic surfaces, sustaining their tenacious bonds in saltwater, including turbulent tidal environments. Little is known, however, about exactly how th...

Nicotine exposure during development leads to hearing problems

...pect of smoking is so harmful in pregnancy when it comes to cognitive hearing deficits," Metherate said. "Most women who smoke find it difficult to quit during pregnancy. For them, doctors often prescribe a nicotine patch. While that does protect the fetus from the well-known physical under-development rel...

Heart has enough oxygen to survive hypothermia, CPR crucial

..." Tveita stated. Thus, it appears that the problem comes as a result of the lower cardiac output, he added. "Thus, efforts aimed at elevating cardiac output in this phase seem advisable in order to optimize oxygen supply, reperfuse (restore blood flow to) vascular beds (minute blood vessels) and prevent...

How ancient whales lost their legs, got sleek and conquered the oceans

...l and all but gone, lack of Sonic hedgehog clearly comes into play. While the animals still may have developed embryonic hind limb buds, as happens in today's spotted dolphins, they didn't have the Sonic hedgehog required to grow a complete or even partial limb, although it is active elsewhere in the embry...

It's all in the genes

...ure." The research also has ramifications when it comes to genetically modified organisms and their effects on the landscapes in which they are introduced. For example, grasses that are genetically altered to prevent weed growth could pass that resistance along to exotic plants, which then might take over...

Tamoxifen for breast cancer prevention does not benefit most women

...wed that taking tamoxifen to prevent breast cancer comes to $123,780 per year of life saved for women at the 1.67-percent risk level. In comparison, annual flu shots cost about $980 per year of life saved for patients ages 65 and older; colonoscopy every 10 years costs about $11,000 per year of life save...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...obesity. Further evidence linking TRB3 to disease comes from recent findings from a team of Italian scientists who report that mutations in the human TRB3 gene are associated with several insulin resistance-related health problems, such as high insulin levels, high cholesterol, and cardiovascular disease....

How can identical twins be genetically different?

...o similar biologically can be so different when it comes to the development of diseases like rheumatoid arthritis. U-M researchers have discovered three genes that are over-expressed in rheumatoid arthritis, or RA, that were not known to be associated with the disease before. They also found that non-gen...

Study reveals how ADHD drugs work in brain

...aluable in the search for new ADHD treatments, and comes amidst deep public concern over the widespread abuse of existing ADHD medicines. "There's been a lot of concern over giving a potentially addictive drug to a child [with ADHD]," says lead author Craig Berridge, a UW-Madison professor of psychology....

Technique speeds up detecting, treating wound bacteria

...ase research. Though Finegold's research funding comes from the Defense Department, his results will help both military and civilian patients. "Most of us in infectious diseases are looking for ways to speed up microbiologic results so that we can treat more intelligently from the beginning," he said. ...

Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds

...minor change in diet can make sense. "If a patient comes in and states, 'Red wine really gives me terrible heartburn,' then it may be reasonable to say, 'Well, you could avoid it, or you could take a medication before you drink some red wine,'" she said. According to the ACG, more than 60 million American...

Silence of the amoebae

... is great, but silence is golden ?at least when it comes to amoebae, which are intestine-dwelling parasites that cause life-threatening dysentery in many parts of the world. Three years ago, scientists at the Weizmann Institute accidentally discovered a way to silence the expression of a key amoebic gene, ...

A catalogue of proteins

...information and the synthesis of new proteins that comes with it. In this study, the proteome researchers looked at liver cells in mice. Using mass spectrometry, and by comparing databases, the scientists were able to detect more than 1400 proteins, localised in ten different cell compartments. Previous a...

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