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Tag: "combined" at biology news

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...interferon system,immunology, and the disease SLE, combined with world leaders in thetechnology for large-scale genetic analyses and statistics. The geneticand statistical analyses were performed by the doctoral student SnaevarSigurdsson and Professor Ann-Christine Syvänen at the Center forClinical Medical Re...

Protein discovery could unlock the secret to better TB treatment

...05 in Nature Structural & Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the fu...

Priming embryonic stem cells to fulfill their promise

... however, when both collagen-1 and fibronectinwere combined in one niche, the liver cell differentiation rate wassubtly inhibited. "You would not predict that from the customary cellbiology experiments," said Bhatia. "By using this combinatorialtechnique we were surprised to find many interesting interactions...

Fox Chase Cancer Center scientists identify immune-system mutation

...f Melvin Bosma, Ph.D., discovered mice with severe combined immune deficiency (SCID), a condition that also affects humans. In addition to providing a unique animal model to study the SCID syndrome, SCID mice have become a highly valuable tool for studying the immune system and are now used by scientists worl...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...roarray data produced in different laboratories be combined foranalysis. Even if all procedures and equipment were the same, smalldifferences between labs, such as in handling the tissue samples,extracting the RNA, or scanning the microarrays, could result indifferent profiles.To test the feasibility of multi...

Computers to be used to find blueprint for new influenza drug

... Sciences Research Council to buy computers with a combined power many times that of the most advanced desktop machines. This will be the first time the software, developed in Germany, will have been used in Britain. It will allow accurate modelling of the behaviour of tens of thousands of atoms, many times ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...ppens to cancer cells whentelomerase inhibition is combined with inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The researchers found that both tankyrase 1 activity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyr...

GATA: a graphic alignment tool for comparative sequence analysis

...ppens to cancer cells whentelomerase inhibition is combined with inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The researchers found that both tankyrase 1 activity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyr...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...M. tuberculosis. "What the structure showed, when combined with careful analysis of the sequence, its neighbors in the genome, and the fact that its gene was also regulated by iron, was that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobac...

Researchers reveal the infectious impact of salmon farms on wild salmon

...rm on sea lice outbreaks in wild salmon. The study combined new field techniques that allowed comprehensive, individual observations of over 5,500 young wild pink and chum salmon over 60 km of migration route; an enormous data set from months of laborious fieldwork; and state of the art models of disease tran...

Purdue proves concept of using nano-materials for drug discovery

...ces with an enzyme that produces a blue color when combined with a liquid that contains molecules small enough to easily pass through the pores. The enzyme, which is a protein, was placed inside the vessels - on the inner surface of the alumina membranes - and the liquid was placed outside each vessel so that...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...hey came up with a whole new method of inquiry. It combined two pre-existing technologies -- RNA interference (RNAi), where scientists cut down on protein expression by jamming the responsible gene with bits of RNA; and microscopy, which looks at the activity of individual living cells by attaching a fluoresc...

Researchers add new tool to tumor-treatment arsenal

...Dr. Thomas. "However, a narrow therapeutic window, combined with possible severe side effects, has greatly limited their broader use." These factors, says Dr. Thomas, have probably contributed to recent reports of the under-dosing of patients and the failure to blunt the disease. When cancer cells are treat...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...re being forced to multiply by MYC." But even the combined effect of MYC and TEL2 wasn't enough to turn these overactive lymphocytes into lymphoma cells. "The coup de grace consisted of a complete elimination of the apoptotic response through loss of p53 function," Grosveld said. "In fact, all TEL2/MYC B-ce...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

... human. Databases of genomic information have been combined with databases that list the precise subunit sequence of proteins as well. Cross-species DNA and protein comparisons have become routine for all biologists with computerized search programs, the most popular of which is called BLAST. The wiring anal...

Falling ants glide back to trunk to avoid dangers of forest floor

...r the tree trunk. Yanoviak's earlier observations combined with the videotaped tests in Panama established th...ave long, slightly flattened hind legs which, when combined with abdominal movements, might allow the ants to reorient in midair. They also have an unusual flat...

In the migratory marathon, parasitized monarchs drop out early

...at overwintering sites and climate warming trends, combined with an increase of tropical milkweed species in m...n their hosts could have a much larger impact when combined with the stresses of long-distance migration. ...

Vascular structure and function improve with diet and exercise

...pen in even eight weeks." Researchers studied the combined effects of personalized physical exercise and Mediterranean-style diet plans in volunteers with pre-clinical risk factors for cardiovascular disease. The study reported preliminary data from the larger randomized Staged Nutrition and Activity Counsel...

PET/MRI scans may help unravel mechanisms of prenatal drug damage

... Medicine, used positron emission tomography (PET) combined with magnetic resonance imaging (MRI) to track the...detail of the tiny fetal organs. The current study combined PET with high-resolution magnetic resonance imaging (MRI) to track cocaine pharmacokinetics down to ...

New online portal merges vast data on Gulf of Maine ecosystem

... changing over time. And the data can be mined and combined to examine more complex relationships, such as the way the abundance of one species may vary with another, or how species may be affected by variations in temperature and currents. To illustrate, one can quickly see changes in the abundance and dist...

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