No small feat: First ever gene therapy success for muscular dystrophy achieved
...itt researchers might also explore approaches that combine genes that promote both muscle and nerve growth, as well as focus on improving the AAV vectors. In addition to Drs. Xiao and Qiao, other authors are Jianbin Li; Tong Zhu, M.D., Ph.D.; Xiaojung Ye, M.D., Ph.D.; Chunlian Chen; and Juan Li, M.D., all f...NYU biologists map out early stages of embryo formation
...g diagram for embryo formation. Using a new way to combine results from different functional genomic approaches including RNA interference (RNAi), a method for studying the function of genes in vivo, the researchers were able to develop a first-draft diagram for the early embryo at the molecular level, descr...NHGRI expands effort to revolutionize sequencing technologies
... sequenced. The group will then demonstrate how to combine the sequence and maps into distinct haplotype sequences. Gregory L. Timp, Ph.D., University of Illinois at Urbana-Champaign. $2.1 million (3 years) "Sequencing a DNA Molecule Using a Synthetic Nanopore" This group will explore the feasibility of se...Fighting malaria by manipulating mosquitoes' sense of smell
...ar. Current efforts to control this disease, which combine the use of insecticides with improved access to effective diagnosis and treatment, have great potential to save lives but face enormous challenges and cannot eradicate malaria without the development of complementary control technologies. Recent adv...On a wing and a prayer - Alaska researchers seek clues to bird flu
...iate professor of biology at UAF. "Our ability to combine studies in natural history and biomedicine is why I came to UAF," Runstadler said. "We are best able to do this type of research at UAF because we have the expertise in biological and ecological science, the state resources, and now the biomedical ca...Many smokers fail to quit after cancer diagnosis
...ount. Targeted interventions have been designed to combine elements of behavioral therapy and pharmacotherapy, but only a few studies exist assessing their efficacy. Another shortfall is that these studies, with one exception, target smokers with smoking-related cancers. The common finding was that the healt...Mouse genome much more complex than expected
...es. For example, the 'copiers' in the cell nucleus combine the different 'paragraphs' in the DNA encyclopedia with each other in different ways. Thus there may be several different mRNA copies derived from the same page, which in turn serve as a blueprint for different proteins. Only twice as many genes as...Cyberkinetics, Case to develop system to help restore extremity function
...l spinal cord injury (SCI). The joint project will combine limb movement technology developed at Case and the...rol of paralyzed muscles. "We are very excited to combine Cyberkinetics' unique expertise in human brain interfaces with the FES Center's unique expertise in ...New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
...r manipulating them -- into cell lines, where they combine to form a virus. For the Science study, Jeffery Taubenberger of the Armed Forces Institute of Pathology provided the coding sequences for the eight Spanish flu genes to Christopher Basler, Peter Palese, Adolfo GarcíˇSastre and their colleagues at th...Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
...ently stored. This latest study is the first to combine fluorescent dye imaging developed by Galizia, and advanced image processing and mathematical data analysis developed by Galán to actually detect a working memory trace. In the current research, the scientists studied clusters of neurons called glom...DNA technique measures suitability of soil for onion crops
...atory for Nematology, Blgg managed to successfully combine the fundamental knowledge from the patent with state-of-the-art laboratory practice. The result is a practical test that conclusively demonstrates the presence of both the stem nematode and onion white rot. Both parties are continuing to work on th...Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods
...lipid detection in the oral cavity. The authors combine genetic, morphological, behavioral and physiological approaches to pinpoint the multifunctional glycoprotein CD36 (also termed fatty acid transporter, FAT) as the sensor for fat. They show that lingual stimulation of CD36 by fatty acids influences b...Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...colleagues are now conducting studies on mice that combine the vaccine with an adjuvant, a formulation that may lengthen the time the vaccine is effective. An adjuvant, such as alum, is an ingredient that enhances the immune response of a stand-alone vaccine. Other common vaccines, such as tetanus, are typic...Intelligently designed molecular evolution
... make different parts of a molecular compound, and combine them to obtain a final product that could do whatever you needed it to do." Since plasticity residues also play other important biological roles, in addition to the evolution of promiscuous proteins, Keasling and Yoshikuni said their technology, wit...Researchers reverse juvenile diabetes in animal model
...tion of T cells. Once harvested, researchers then combine the dendritic cells with specific blockers of mole...e." In addition, Dr. Trucco and his team want to combine the dendritic cells with small portions (i.e. peptides) of insulin. Dr. Trucco believes that adding ...Light activated anticancer drug targeted to DNA using cisplatin like sub-units
... group has developed supramolecular complexes that combine light-absorbing PDT agents and cisplatin like units. Previous anticancer molecules created by the group have contained platinum-based molecules that bind DNA. They have also developed new light activated systems able to photocleave DNA. This report ...The closest look ever at the cell's machines
...his data and from the methods we are developing to combine computational and biochemical investigations of the cell." "This is an important milestone towards a more global and systems-wide understanding of the cells of organisms ranging from yeast to humans," says Peer Bork, Head of the Structural and Compu...University of Utah to help build bionic arm
...er wirelessly to the electrode array. It also will combine the electrode array with signal processors and amplifiers so that the implanted device ?less than one-third inch on a side ?can relay signals back and forth wirelessly between the remnant limb, the computer and artificial arm. This work falls under a...Both alcoholism and chronic smoking can damage the brain's prefrontal cortex
...er wirelessly to the electrode array. It also will combine the electrode array with signal processors and amplifiers so that the implanted device ?less than one-third inch on a side ?can relay signals back and forth wirelessly between the remnant limb, the computer and artificial arm. This work falls under a...Attention shoppers: Researchers find neurons that encode the value of different goods
...a choice, for example: between different foods, we combine all these attributes--we assign a value to each available item," says Camillo Padoa-Schioppa, PhD, HMS research fellow in neurobiology and lead author of the paper. "The neurons we have identified encode the value individuals assign to the available ...