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Tag: "combinations" at biology news

New technique boosts size of proteins that can be analyzed

...tein, and masses can usually be matched to several combinations of pieces and modifications. Therefore, the method rarely locates all modifications in newly isolated proteins. "Each approach has different strengths and weaknesses," said Mi Jin, a postdoctoral associate in chemistry and chemical biology and one ...

New clues to how sex evolves

...s evolve rapidly because they are modular, so that combinations of elements allow them to move quickly to new binding sites on DNA, making the Pairing Centers of different chromosomes unique," she says. "Telomeres, on the other hand, are all very much alike, no matter which chromosome they're on. It could be that...

Researchers seek to design first treatment for neuroAIDS

..., despite early reports to the contrary. Antiviral combinations only slow the onset of HIV-related nerve damage that is becoming more common the longer HIV patients live. Where patients suffered rapid, severe neurological damage before combination therapy, they now gradually lose attention span, memory, speaking...

Plant studies reveal how, where seeds store iron

...t is a wonderful example of the power of using new combinations of tools--in this case, genetics and high-resolution 3-dimensional X-ray fluorescence imaging--to understand gene function," said Jane Silverthorne, a program director in NSF's Division of Biological Infrastructure, which funded the research. "The di...

Early-stage immune system control of HIV may depend on inherited factors

...eport that specific HLA Class I/HIV viral fragment combinations are associated with a more powerful antiviral response, findings that may help develop vaccines against HIV. "We found that only a limited number of viral protein fragments from HIV-1 are targeted by the immune system in early infection and that th...

Proteins may predict lung transplant rejection

... research is continuing to determine which protein combinations are the best predictors and whether some biomarkers may be better than others at different points of the disease's development. The information could offer inroads to new therapies, said Wendt. Doctors may be able to increase the dose of anti-reje...

Plant studies reveal how, where seeds store iron

...t is a wonderful example of the power of using new combinations of tools--in this case, genetics and high-resolution 3-dimensional X-ray fluorescence imaging--to understand gene function," said Jane Silverthorne, a program director in NSF's Division of Biological Infrastructure, which funded the research. "The di...

Manual dishwashing study digs up dirt on dish cleanliness

... able to do that, and we did it by using different combinations of washing, rinsing, and sanitizing." But all dishes are not created equal. Compared to ceramic plates, steel knives, spoons, and plastic trays, steel forks seemed to be the best home for bacterial contaminants. "The prongs of forks actually sh...

Too much of a good thing? Excess nutrients or water limit biodiversity

...e Santa Ynez Valley, where the researchers applied combinations of nutrients and water to plots of grassland. Plots that received all of the resources had the fewest species and highest productivity. They combined this with analysis of the 150 year old Rothamsted Park Grass Experiment. Both supported their hypoth...

40,000-year-old skull shows both modern human and Neandertal traits

...ic traits retained from the Neandertals and unique combinations of traits resulting from the blending of previously divergent gene pools. "The ultimate resolution of these issues must await considerations of larger samples of European early modern humans and chronologically intervening specimens. But this foss...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...gly associated with response. Predictors based on combinations of molecular correlates of response were able to quantitatively predict individual cell line responses. "The concordance of our markers of response to lapatinib with those observed clinically suggests that the molecular markers identified in the ...

Massey researchers induce cell death in leukemia

...nteractions between HDAC inhibitors and Bortezomib combinations in the setting of CLL," said Grant. "The findings of our study -- as well as the emerging body of preclinical and early clinical data suggesting interactions between HDAC inhibitors and bortezomib in other tumor cell types, particularly hematologic m...

Phthalates now linked to fat, related health risks

..." Stahlhut said. "The more difficult issue is what combinations of common low-dose chemical exposures might be contributing to these problems."...

A genetic 'gang of 4' drives spread of breast cancer

...o test this idea, the researchers silenced various combinations of the four genes in human breast cancer cells that had metastasized to the lung, and then tested these cells in mice. To silence the four genes, the scientists used a technique called RNA interference, in which RNA molecules are tailored to suppress...

Genes set scene for metastasis

...cer cells). The researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer. ...

Hybrid molecule causes cancer cells to self-destruct

... the researchers tested three other sugar-butyrate combinations and a butyrate salt compound with no sugar attached. The four other formulas and the butyrate-ManNAc hybrid were each added to lab dishes containing cancer cells. After three to five days, cancer growth had slowed in all of the dishes. After 15 days,...

Remote sheep population resists genetic drift

...ersity refers to the total amount of possible gene combinations that a mating male and female couple can produce. Scientists believe greater genetic diversity corresponds with greater odds of survival and successful reproduction due to a greater variety of genetic tools an organism has to combat the forces, such ...

Bacterial walls come tumbling down

...aboratory. But after much tinkering with different combinations of detergent, ions, and chemical additives, Strynadka's team was able to crystallize the enzyme so that it would diffract x-rays into a pattern that would ultimately reveal its natural structure. They then were able to repeat the feat to reveal the c...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

... time in order to know if its effects in treatment combinations are as positive as the results on test animals predict. Aside from this, there are another four members of this monoclonal antibiotic family, which stimulate the immune system, currently being developed. Their use in patients began a year and a ha...

Genome sequencing reveals key to viable ethanol production

... more than 100 enzymes, and any of the millions of combinations of them may be the magic mixture to break down a p...had to be observed as a whole, since fiddling with combinations of two, three, or more enzymes at a time would have taken "more than our lifetime," Wu says. Wu is...

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