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Tag: "combinations" at biology news

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...kely increase antibiotic yields. Shuffling creates combinations of all mutants that originally generated increased yields--similar to genetic recombination--and produces sequences with multiple mutations more quickly. Think of a genome as a deck of cards, and inducing a beneficial mutation as slipping in a joker...

Leprosy genome tells story of human migrations, French researchers report in Science

...be substituted, making for a possible 64 different combinations in the genetic sequence. In a study of 175 differe...global pandemic," Cole said. Each of the four SNP combinations was most common in a certain geographic region, allowing the researchers to trace how the pathogen h...

MIT engineers an anti-cancer smart bomb

... us to rationally and systematically evaluate drug combinations and loading mechanisms," says Sasisekharan. "It's not going to stop here. We want to build on this concept." ...

Improved statistical tools reveal many linked loci

...genome. "We were interested in being able to find combinations of genes that affect the phenotype," says Kruglyak. "It's generally thought that most traits of interest have a complex underlying genetic basis, but it's generally been pretty difficult to get at those." Typically, researchers might be able to find ...

Environmental chemical cocktail may sabotage sperm

New research has shown that combinations of chemicals found in everyday products and food h...ls] are effective at very low concentrations, with combinations of compounds being even more potent, these results could have important negative implications for hu...

New research could help us deliver genes for new bone formation

...are investigating the most efficient and effective combinations of genes and delivery scaffold to trigger the highly complex process of bone formation. The technique, if successful, could provide a new source of bone tissue for orthopaedic procedures. Professor Richard Oreffo, who is leading the team at the Univ...

Crisis in African fish supplies looms, experts warn Africa leaders

... Called "rich food for poor people," fish contain combinations of proteins, vitamins and minerals that help fortify people with HIV and AIDS against secondary infections while increasing the effectiveness of retroviral drugs. "Small fish ponds are a valuable addition to farms without substantially adding to the...

Tagging pathogens with synthetic DNA 'barcodes'

...sted their system using samples containing various combinations of E. coli, anthrax and tularemia bacteria and ebola and SARS viruses, and have found the color codes could clearly distinguish several different pathogens simultaneously. The research is described in a paper, "DNA fluorescence nanobarcodes for mult...

Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice

... Called "rich food for poor people," fish contain combinations of proteins, vitamins and minerals that help fortify people with HIV and AIDS against secondary infections while increasing the effectiveness of retroviral drugs. "Small fish ponds are a valuable addition to farms without substantially adding to the...

Discovery of T-cell 'traffic control' boosts new drug promise

...ss will also come from finding "uniquely effective combinations of these agents with other immunosuppressive drugs," he says. In animal studies and clinical research with patients over more than a decade, scientists have come to understand that millions of T cells and B cells are "called" into lymph nodes by oth...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...gers," explains Li. Also, the number of possible combinations of eight-block-long protein segments provides a "reasonable number" to sort through -- 25 billion or so -- given today's high throughput technologies. To make it even easier, Shikano developed a system that would separate the wheat from the chaff bef...

Sleeping beauty plays a significant role in identifying cancer genes

...hat current methods do not -- such as the specific combinations of mutant genes that can work together to cause cancer. "With this information, we will understand the development of tumors at the genetic level in much finer detail," he said. "This is important because no single kind of cancer is going to be cured...

New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity

...educe how many transcription factors at a time, or combinations of factors, are coming together physically and how these combinations regulate genes." "To accomplish this," Komorowski said, "we used a machine learning technique calle...

Researchers create functioning artificial proteins using nature's rules

...made up of 100 amino acids, the number of possible combinations of amino acids is staggering, many times more than the number of atoms in the known universe. "How did nature devise the right sequences that resulted in functioning proteins? Somehow, it found a way," Dr. Ranganathan said. "One implication of our ...

New gene scanning technology marks a major advance in disease research

...ne and screening.' Professor Day's group is using combinations of meltMADGE and a second technology called endo VII MADGE to explore variations in the whole population of disease genes relevant to growth, obesity and cardiovascular disease. ...

Complex gene interactions account for autism risk

... them to rigorously test for the role of such gene combinations in autism for the first time, she said. The researchers reported their findings in the September issue of The American Journal of Human Genetics (available online August 3, 2005). The work was supported by the National Institutes of Health, the Nati...

DNA self-assembly used to mass-produce patterned nanostructures

...tiles or itself. "It turns out there are a lot of combinations to consider," Dwyer said. "That meant running a lot of searches. We had to run three hundred computers for two weeks to get an answer." The answer for the optimal base configurations for each DNA strand was disclosed to Duke's Office of Licensing an...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...pakesan. He and his group placed antibody-nanotube combinations between electrodes and compared the increase in electrical charge between two different types of breast cancer cells. One type, human BT474 breast cancer cells, had moderate IGF1R expression, while the other type, MCF7, had a higher expression of IGF...

HIV drug resistance increasing in UK and among highest in the world

...vements to health since people with HIV were given combinations of drugs (combination antiretroviral therapy) may be compromised because of this. Using national data on HIV positive cases, the researchers tested patients for resistance to the antiretroviral drugs before embarking on the treatment. Tests were con...

New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus

...nces of viral RNA into bacteria and then inserting combinations of the genes -- often after manipulating them -- into cell lines, where they combine to form a virus. For the Science study, Jeffery Taubenberger of the Armed Forces Institute of Pathology provided the coding sequences for the eight Spanish flu gen...

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