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Tag: "combination" at biology news

Gene elevating breast cancer risk also causes prostate cancer

Cancer is a complex and common disease caused by a combination of both genetic and environmental factors. An inherited predisposition seems to be involved in at least 5?0 per cent of all cases of breast cancer. The two major familial breast cancer susceptibility genes BRCA1 and BRCA2 only explain 20-30 per cent ...

Radiation therapy combo cures prostate cancer long-term

Seventy-four percent of men treated with a combination of radiation seed implants and external beam radia... Prostate Institute. Doctors wanted to look at the combination of seed implants and external beam radiation therapy, two different types of radiation therapy, to p...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...loped while at the University of Pennsylvania, the combination of Kras and p53 led to the more deadly form of pan...ase progression. The current study showed that the combination of Kras and an early mutation of Dcp4, in which one copy of the suppressor gene is eliminated, lead ...

Cancer-killing invention also harvests stem cells

... into bone marrow cells. The device itself uses a combination of microfluidics, or fluid flow properties, and specialized selectin coatings. Killing Cancer Cells Another exciting application of King's invention is filtering the blood for cancer cells and triggering their death, an innovative, new metho...

Chemo combination improves survival in asbestos-related cancer

...e ?have a higher survival rate when treated with a combination of two cancer drugs, a large multicenter study fin...le drug or the combination. "Pemetrexed used in combination with cisplatin significantly increases the length of survival, when compared with cisplatin alone," ...

Putting an old drug to a new use

... "Our discovery is an excellent example of how the combination of basic research and the expertise of clinicians can yield results that are relevant to medicine and could ultimately benefit patients," says Matthias Hentze, Associate Director of EMBL and co-author of the study. "In the Molecular Medicine Partners...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...ty much simplified our view of DNA helix as a Lego combination of four different pieces, which encodes genetic information and contain patterns, recognized by DNA binding proteins. However, nucleic acids are real molecules with defined physical characteristics, which can influence their biological functions." ...

Scripps research study reveals structural dynamics of single prion molecules

...in an inheritable manner. The research team used a combination of advanced biophysical methods to investigate the...ion about this particular monomer," he said. "This combination of techniques can now be used to study other amyloidogenic proteins, including prions, particularly ...

Massey researchers induce cell death in leukemia

...s annual meeting suggesting the potential of a new combination treatment for chronic lymphocytic leukemia (CLL). In this study, led by Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib and romidepsin (Gloucester Pharmaceuticals) and bortezomib with beli...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

... (patients?own) dendritic cells (DC) pulsed with a combination of three peptides: two that trigger cytotoxic T ce...e cytotoxic p53 peptides are delivered alone or in combination with a helper T cell-activating peptide that is either specific to p53 or not specific to p53. ...

Protein sensor for fatty acid buildup in mitochondria

...arnitine shuttles them into the mitochondria. This combination of a fatty acid and carnitine, called acylcarnitine, liberates PanK2 from the bondage of CoA. Once free, PanK2 resumes its job of initiating the production of more CoA, which is needed for the breakdown of fatty acids—a process called beta-oxidation....

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...udied 114 patients who had been given cetuximab in combination with another drug, irinotecan. According to th...eptides that bind to tumors that are affected by a combination of radiation and tyrosine kinase inhibitor therapy, but not to tumors that do not respond to therapy...

Dual gene therapy suppresses lung cancer in preclinical test

...ors by 80 percent. "In cancer treatment we have combination chemotherapy, and we also combine different modes ... as apoptosis. Further analysis showed that the combination achieved greater cell suicide because FUS1 suppresses a gene that expresses a protein known to rapid...

Chemical switch triggers critical cell activities

... The investigators were able to make sense of this combination of relay race and rotating paddle wheel by using a technique called X-ray crystallography. In X-ray crystallography, scientists bombard crystals of proteins with X-rays and use the patterns formed by beams bouncing off the crystals to create computer...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

... trial had been treated with front line cisplatin combination chemotherapy, which failed to halt their disease. The clinical trial continues. No maximum tolerated dose has been established, Lu says. The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA that encodes...

Researchers discover surprising drug that blocks malaria

...en Haldar and her colleagues tested propranolol in combination with existing anti-malarial drugs in human cell cultures and mice, it reduced the dose of the anti-malarial drugs needed to kill the parasites by tenfold. That's significant because high doses of anti-malarial drugs ?increasingly necessary as resis...

UF scientists discover new genus of frogmouth bird in Solomon Islands

...and-me-down classifications from an earlier era. A combination of detailed morphological and genetic analyses reveal that this frogmouth ?formerly dismissed as just a race of an existing species ?actually cannot be placed confidently in any existing genus, and so the data demand naming a new one." Storrs Olso...

The origin of the brain lies in a worm

... structures. The regions are defined by the unique combination of regulatory genes expressed, which endow every type of neuron with a specific molecular fingerprint. Comparing the molecular fingerpint of Platynereis nerve cells with what is known about vertebrates revealed surprising similarities. "Our finding...

No sex for 40 million years? No problem

...ey have evolved into distinct species. Using a combination of DNA sequencing and jaw measurements taken using a scanning electron microscope, the research team examined bdelloid rotifers living in different aquatic environments across the UK, Italy and other parts of the world. They found genetic and jaw-sha...

Susceptibility to Crohn's disease -- an important new clue

...ses, including Crohn’s disease, is determined by a combination of environmental and genetic factors and identifying these genetic risk factors is one of the most important objectives of modern medical genetics, potentially paving the way towards personalized medicine and drug target identification. ...

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