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Tag: "colorectal" at biology news

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors. It has been established that interfering...

Boosting HIV screening can increase survival and is cost effective

...other chronic conditions, including breast cancer, colorectal cancer, diabetes and hypertension. Paltiel said that even in settings with HIV infection levels similar to the U.S. general population, one-time screening could deliver excellent return on investment. "HIV is a severe disease that, left untreated, p...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...hronic myeloid leukemia and Erbitux for metastatic colorectal cancer. "FDA's efforts will bring us one step closer to 'personalizing' medical treatment," explained Janet Woodcock, M.D., Acting Deputy Commissioner for Operations, FDA. "This new technology will allow medicines to be uniquely crafted to maximize ...

Turning viruses into allies against cancer

...es, including melanoma, breast, head and neck, and colorectal cancer. In early clinical studies, the engineered...ast, three with head and neck cancer, and two with colorectal cancer. Each patient, all in the later stages of their disease, received either a single injection o...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

... two. The APC gene is responsible for an inherited colorectal cancer condition known as FAP (familial adenomatous polyposis), in which patients develop hundreds of potentially precancerous polyps. They found that on the AIN-76A diet, loss of one APC gene but retention of the "wild-type" (normal) p27 genes was ...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...dy** that already has been approved for metastatic colorectal cancer in combination with chemotherapy, is designed to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis. “It is noteworthy that a previous company-sponsored trial in p...

Important discovery about second most fatal cancer

... Australia and Japan have shown that in some cases colorectal cancer can be inherited. The new syndrome is chara...ariable levels of DNA instability across different colorectal cancers occurring in members of same family # Origin in serrated polyps (considered previously to be...

Scientists turn tobacco against cancer

...llege, inserted DNA coding for an antibody against colorectal cancer into tobacco plants. The plants, in turn, b...nize a particular type of protein antigen on human colorectal cancer cells and have been used in treating metastatic disease and in preventing recurrence in certa...

NIH renews network focused on how genes influence drug responses

...cluding those used to treat childhood leukemia and colorectal cancer. (Mark Ratain, M.D., University of Chicago, and Mary V. Relling, Pharm.D., St. Jude Children's Research Hospital) Pharmacogenomics of Arrhythmia Therapy --$14 million provided by NHLBI to discover the common DNA variants that determin...

Treatments have same target, different responses for lung cancer patients with genetic mutation

... which is approved for the treatment of metastatic colorectal cancers that overexpress EGFR. Cetuximab targets EGFR by preventing its activation by extracellular signals, or signals occurring outside of the cell, as opposed to the intra-cellular signal blocking of drugs like gefitinib. The researchers treate...

Sleeping beauty plays a significant role in identifying cancer genes

...us on identifying genes causing prostate, lung and colorectal cancer; Jenkins and her team will study genes for tumors in the brain, melanoma, breast, leukemia and lymphoma. Largaespada, Jenkins and Copeland acknowledge the difference between research in mice and actual use in humans. But as Largaespada pointe...

Change in gene may be underlying molecular defect in some colorectal cancers

...ay be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for t...on may ultimately be useful in risk assessment for colorectal cancer, according to a new study in the September 21 issue of the Journal of the National Cancer In...

Two designer drugs hit same lung cancer target, but only one is effective

...bitux is an effective inhibitor of EGFR signals in colorectal cancer, which involves a normal, not mutant, EGFR ...luding lung cancer of the non-small-cell type, and colorectal cancer, the abnormal signals are generated by a normal EGFR molecule. In a small percentage of patie...

Scientists discover genetic pathway responsible for breast cancer cell growth

... on agents such as Gleevac in leukemia, Avastin in colorectal cancer, and more recently with Herceptin for breast cancer, confirm that the efforts of researchers like Dr. Giguere and his team save lives and money. These connections between research and health care are one of the strengths of academic hospitals ...

Minimally Invasive Cancer Treatments Highlighted

...assessing survival in patients with small solitary colorectal liver metastasis treated with RFA shows that their survival was extremely good, with 3 and 5 year survival after ablation of 65% and 43% respectively. (Author, Gillams) Non-Surgical Pain Treatments for Bone Tumors (Tuesday, November 29) Cancer ofte...

Predicting chemotherapy outcome

...ying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemot... Biology, researchers identified in the tumours of colorectal cancer patients almost 700 genes whose expression was different between patients who subsequently re...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

... does not even require surgery. Most patients with colorectal cancer have surgery, but some, even at the earlies...t is very difficult to predict which patients with colorectal cancer will be cured by surgery alone - the single treatment most patients receive - and who might b...

AIDS-related cognitive impairment exists in two separate forms

... does not even require surgery. Most patients with colorectal cancer have surgery, but some, even at the earlies...t is very difficult to predict which patients with colorectal cancer will be cured by surgery alone - the single treatment most patients receive - and who might b...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...eat conditions like arthritis, have lower rates of colorectal polyps, colorectal cancer, breast cancer and many other cancers. NSAIDs exert anti-inflammatory effects by blocking COX...

RNA interference stops colon cancer spread in mice

...ve scored a dramatic success in the battle against colorectal cancer. The scientists were the first to use what...all interfering RNAs" to block the spread of human colorectal cancer cells implanted in laboratory mice. Small interfering RNAs (siRNAs), first described in 2001,...

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