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Tag: "colon" at biology news

Scientists inhibit cancer gene

... to promote the growth of cancers in the pancreas, colon and lung, as well as thyroid cancer and leukemia. Attempts to inhibit activated Ras have had limited success until now, but the Huntsman Cancer Institute researchers explain that they have discovered an enzyme that, when inhibited, appears to reduce...

Researchers develop promising new gene network analysis method

...rotein is produced unchecked, it can cause breast, colon and other types of cancer. C-Myc contributes to more than 70,000 deaths in the United States each year. Once the c-Myc switch is thrown, thousands of other genes start pumping out proteins or switching on other genes, which activates still more gene...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...e and human blood vessels that feed tumors such as colon cancer, melanoma and lung cancer. Inhibitors of the integrin stopped new blood vessel growth and suppressed tumor growth, indicating that the integrin helped in the creation of tumors "Our study marks the first time this integrin was found to play a...

Change in gene may be underlying molecular defect in some colorectal cancers

...mucosa of 95 colorectal cancer patients and in the colon mucosa of 33 subjects without cancer. MGMT promot...g on the method of detection, and normal-appearing colon mucosa up to 10 cm away from the tumor had detectable MGMT methylation. In addition, the authors det...

Columbia scientists develop cancer terminator viruses

...ast, brain (glioma), prostate, skin (melanoma) and colon cancer - because the virus is constructed to exploit a characteristic of all solid cancers. However, clinical trials are necessary before such treatments can be approved by the U.S. Food and Drug Administration and available for patients. These pub...

Anti-cancer Compound In Beer Gaining Interest

...vonoids for everything from preventing prostate or colon cancer to hormone replacement therapy for women. ...er properties. It showed toxicity to human breast, colon and ovarian cancer cells, and most recently has shown some activity against prostate cancer in OSU s...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...hells into the blood stream of mice implanted with colon cancer knowing, based on previous experiments, that the nanoshells would preferentially accumulate in the tumors. This occurs because blood vessels that develop in fast-growing solid tumors are ill-formed and permeable, and nanoshells traveling throu...

New view of cancer: 'Epigenetic' changes come before mutations

...ore primitive precursor cells in the lining of the colon than normal mice. When these mice also carried a colon-cancer-causing genetic mutation, they developed twice as many tumors as mice with normal IGF2 levels. The extra IGF2 stemmed not from a genetic problem, or mutation, but from an epigenetic proble...

Cancer support cells may evolve, fuel tumor growth, study shows

... forms the framework of organs such as the breast, colon and prostate. They also are found in the tumor's blood vessels, or its vasculature. "Basically, virtually all the studies on genetic changes or changes in gene expression have focused on the cancer cell, on events within the cancer cell itself," sai...

NIH launches comprehensive effort to explore cancer genomics

...tium. Genetic mutations linked to breast cancer, colon cancer, melanoma, and other cancers already have led to diagnostic tests that can point to the most effective intervention. Recent discoveries in cancer genomics have helped to identify several treatments that work by targeting cancer cells with a sp...

Common molecular 'signature' identified in solid tumors

...in 540 samples of lung, breast, stomach, prostate, colon and pancreatic tumors and in the normal tissue surrounding them. Using microarray technology developed at Ohio State , lead investigators Stefano Volinia and George Calin found 137 different miRNAs expressed in at least half of the cancers, with 43...

Cancer cells suppress large regions of DNA by a reversible process that can be tackled

...e found large regions of DNA are 'switched off' in colon cancer. Lead researcher Associate Professor Sue Clark, of the Garvan Institute, says: "These large regions ?referred to as suburbs ?contain genes that normally function to prevent the development of tumours". Our cells become cancerous when the norm...

Lack of a key enzyme dramatically increases resistance to sepsis

...re able to use a surgically implanted stent in the colon that allowed a gradual occurrence of sepsis and easy identification." A majority of mice with caspace-12 died from sepsis within the first 48 hours after onset, while 60 percent of the caspase-12 deficient mice survived. The deficient mice also show...

Scientists one step closer to cancer vaccine

...umours from different tissues, including melanoma, colon cancer, lymphoma, and fibrosarcoma. "So far we've only conducted research on mice, so it's too early to get out hopes up too much," says research scientist Elisabeth Wolpert at the Microbiology and Tumour Biology Centre. "However, the study does poi...

Spousal illness can trigger partner death

...spitalized wives, if the wife was hospitalized for colon cancer, there was almost no effect on her husband's mortality. But if a wife was hospitalized with heart disease, her husband's risk of death was 12 percent higher than it would be if the wife was not sick at all. If a wife was hospitalized with deme...

Basic research leads to a novel cancer therapy

...of bladder cancer, breast cancer, cervical cancer, colon cancer, esophageal cancer, head and neck tumours, liver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of...

Predicting chemotherapy outcome

...alyse the gene-expression patterns of samples from colon tumours and liver metastases collected from 13 pat...findings were also confirmed by RT-PCR analysis of colon and liver tumour samples collected from two additional patients. The authors were able to integrat...

UCSD team unmasks family of immune system invaders

...that blocks bacterial entry from the intestine and colon into the rest of the body. However, bacterial pathogens can inject effector proteins into the intestinal epithelial cells, creating a door in the barrier. "As a result, these bacteria proteins are the bad guys that make you sick," said Alto. "Inst...

New test to detect rare proteins in blood

...for other cancer markers including lung cancer and colon cancer. All proteins tested so far with FACTT have been detected with an over 1000-fold higher sensitivity compared to current technologies. The researchers say this points to FACTT's broad applicability and compatibility with current high-throughpu...

Molecular force field helps cancer cells defend against attack

...highways for cancer spread and is found in breast, colon and thyroid tumors. Cance and colleagues were the first to pull FAK out of human tumors and to show that human cancers make the molecule in large quantities. In 1996, the team was the first to show that if a tumor is prevented from producing the enz...

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