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Tag: "collagen" at biology news

Scientists develope a new model of artificial canine skin

... dogs were used. The dermis cells, inserted into a collagen marix (a very common protein in skin and joints), were used as a support for the epidermis cells, which were grown on its surface and were kept in growth conditions exposed to air. The cells proliferated forming the various layers of the epidermis. ...

Growing nerve cells in 3-D dramatically affects gene expression

...lagen. They suspended the other batch in a thicker collagen gel. The bioengineers took great pains to be sure that this one-dimension difference was the only difference in the culture conditions. Team members even counted individuals cells as they went into the dishes to be sure that each dish contained preci...

Nanotextured implant materials: blending in, not fighting back

...cells that make up the arterial wall. The proteins collagen and elastin make up much of this lining and create...top piling on and switch to producing the proteins collagen and elastin. In one experiment, published with Purdue University graduate student Saba Choudhary ...

Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex

... Center have captured and sequenced tiny pieces of collagen protein from a 68 million-year-old Tyrannosaurus r...o most closely match amino acid sequences found in collagen of present day chickens, lending support to a recent and still controversial proposal that birds and...

Cartilage discovery offers arthritis hope

...ets its strength from interlocking millimetre-long collagen fibres that work in a similar way to the load-bear...cular structure of the thinner of the two types of collagen fibrils. Professor Karl Kadler, who led the research in the Faculty of Life Sciences, said: "The a...

Scientists re-grow dental enamel from cultured cells

...s seeded the cultured dental epithelial cells onto collagen sponge scaffolds, along with cells from the middle of the tooth (dental mesenchymal cells). The scaffolds were then transferred into the abdominal cavities of rats, where conditions were favorable for the cells in the scaffolds to interact and develo...

How T lymphocytes attack

... the different cell populations, blood vessels and collagen fibres present. And using a series of successive images, it was possible to reconstitute the trajectory of a T lymphocyte. Using this method, the researchers thus examined the different protagonists ?T lymphocytes and tumour cells ?during two dist...

Researchers show that veins stiffen as we age

...er extremities. The walls of the veins are made of collagen and elastin, two proteins that give the tube-like blood vessels flexibility and help them to maintain your blood pressure. To determine if there are age-related differences in how our veins work, the research team recruited 24 people for their stud...

The effects of smoking on fractures and ligament injuries

...chieve a simple fracture. Researchers used type II collagen expression as a marker of cartilage formation (cho...ular density at the site of injury and used Type I collagen gene expression as a marker for the formation of extracellular matrix, the material outside of cells...

German researchers develop first non-invasive test to measure skin aging

... layers of the skin, combining methods for imaging collagen and elastin, whose degeneration causes the appeara...thness. The technique measures relative amounts of collagen and elastin by a single factor, which can be positive or negative, like temperatures. Higher values ...

Bones at the nanoscale

...half of it is a stretchable fibrous protein called collagen and the other half a brittle mineral phase called apatite. These com-ponents make this biomineralized tissue highly strong and tough. at the same time, In order to understand how this construction is achieved and functions, scientists from the Max Pl...

A new approach to growing heart muscle

...esence and concentration of the fibrin gel, and of collagen generated by the cells as they organized into tissue. Over the course of several days, the fibrin broke down as intended, after fulfilling its role as a temporary support for the cells. This may be a key achievement for future use of BEHM as a tre...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...move in, and they bring furniture too--meaning the collagen they secrete. They even 'remodel.'" Collagen binds...ls, a middle layer called stroma that provides the collagen matrix that gives the cornea its shape, and an innermost endothelial layer. With inlays, some of the...

New engineered drug may offer prolonged arthritis relief

... enzymes that damage joints by breaking down their collagen "framework," Setton explained. She credits team me...t the same inflammatory enzymes that destroy joint collagen also chew ELP from the original drug protein, thereby restoring its activity. "With the ELP tag go...

Cellular traffic backups implicated in skeletal malformations

...inous skeleton. Chondrocytes secrete proteins like collagen into the extracellular space, laying down a rigid ...ill form cartilage. Under a microscope, type II collagen can mainly be found in the extracellular space. Only small amounts can be seen in the cytoplasm. ...

Cigarette smoking impedes tendon-to-bone healing

... rats' surgically repaired shoulders and decreased collagen production, leading to inferior healing. "When ...n the new cells arrive, they make proteins such as collagen to form the junction between tendon and bone. And in the rats exposed to nicotine, we saw lower cell...

Researchers discover new gene responsible for brittle bone disease

...own only as a genetic disorder in the formation of collagen fibers, the protein framework of which bone and ca...ted their bodies to make either too little or weak collagen because of defects or mutations in one of the collagen genes, of which there are more than 20. The c...

Expanding waistlines triggered by your genes

A gene that degrades the body's collagen infrastructure has been shown to make fat cells fa... acts as a metabolic scissors, cutting through the collagen tissue matrix that holds fat in place, which allows fat cells to expand beneath the belly. The col...

Science finds new fix for UV-damaged skin in arthritis treatment

...s showed a reduction in melanin and an increase in collagen ?a key structural protein in skin. Three double-blinded placebo- controlled clinical studies involving more than 200 subjects, including a study supervised by Dr. Kimball, showed improvement in hyperpigmentation and skin tone and a decrease in the si...

Wisconsin scientists find a way to make human collagen in the lab

... not depend in some way on collagen. In medicine, collagen from animals, principally cows, is used to rebuild...n. But for such a commonplace and useful protein, collagen has defied the efforts of biomedical researchers who have tried mightily to synthesize it for use in...

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