Tag: "cofactors" at biology news

Novel Enzyme Shows Potential As An Anti-HIV Target

...e acetylation controls transcription by recruiting cofactors required for transcription. Acetylation and deacetylation enzymes can also target other proteins. Of the three classes of deacetylases known to modify human histones, the sirtuins (SIRT1?) appear to preferentially target a number of nonhistone prote...

An HIV Protein Plays a Surprising Role in Gene Activation

... the TATA-box-binding protein, or TBP) and several cofactors called TBP-associated factors (TAFs). PIC assembly sometimes also requires activator proteins, which can enhance transcriptional activity by supporting proper elongation of nascent transcripts. Tat, an activator encoded in the HIV genome, is require...

PCRM develops world's first cruelty-free insulin assay

...for calf serum--basically a synthetic formula with cofactors and trace elements that promote cell growth. Then, in collaboration with Linco Research of St. Charles, Missouri, Even successfully incorporated antibodies grown in the medium into a test kit for human insulin. A report on the new methodology will b...

Microreactor efficiently regenerates cofactors for biocatalysis

...is the continuous regeneration of molecules called cofactors that permit the synthesis through inexpensive and ...eloped a microreactor that efficiently regenerates cofactors through enzyme-catalyzed reactions. "Enzymes are nature's catalysts, but in some cases, enzymes can...

Cholera pathogen reveals how bacteria generate energy to live

... of the cell membrane. The results showed that the cofactors ?important parts of the enzyme’s machinery ?are all located on the inner side of the membrane, which corresponds to the "intake" port of the ion pump. The second paper was published in the Journal of Biological Chemistry. In this study, Barquera f...

MIT biologists solve vitamin puzzle

... holding electrons and then giving them away. Such cofactors are not consumed in the reaction. Cannibalization of a cofactor has very rarely been observed before in vitamin synthesis or any type of biosynthetic pathway, says Michiko Taga, an MIT postdoctoral fellow in Walker's lab and lead co-author of the ...

Beyond the DNA: Chemical signatures reveal genetic switches in the genome

...he target gene - to which transcription-activating cofactors bind. According to LICR's Dr. Bing Ren, the study's senior author and assistant professor at UCSD's Department of Cellular and Molecular Medicine, the method is widely applicable and its unbiased approach is likely to yield new information on gen...

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