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Tag: "cluster" at biology news

DNA Molecules Used To Assemble Nanoparticles

... steps, Baker said. Baker foresees a nanoparticle cluster in which a single dendrimer carries three single-strands of DNA, each with a sequence specific to the DNA attached to other kinds of dendrimers. Put into solution with these other tinker toys, the molecule would self-assemble into a four-dendrimer co...

New, automated tool successfully classifies and relates proteins in unprecedented way

... and drug targets by helping to show whichproteins cluster together inside a cell.The approach, developed by ...lie disease."Using this approach to spot a protein cluster could help scientistsidentify a common protein structure that enables those proteins togather in one...

Scientists document complex genomic events leading to the birth of new genes

...2. Comprised of eight family members, the RGP gene cluster may help to explain what sets apart humans and other primates from the rest of the animal kingdom. Human chromosome 2 has always intrigued primate biologists; it formed from the fusion of two mid-sized ape chromosomes and is the only cytogenetic di...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...ifferent," says Gourley. "Mitochondria conspire to cluster around the nucleus and work together to supply energy to the healthy, functioning cell. In contrast, the mitochondria in the cancer cell sit all over, isolated and balled up in a quiescent, non-functioning state. Apparently, the rapidly growing cance...

Scientists solve structure of key protein in innate immune response

...d that mutations that interfere with LPS signaling cluster in a separate area near the pocket suggesting that the areas around the pocket are important in LPS transfer. Not only do these findings shed light on how cells recognize pathogens, they also may also lead to the development of drugs to help treat s...

Asthma gene clusters identified

...ters in all, consisting of 161 genes. At least one cluster was identified that was comprised of genes active in acute asthma, but not stable asthma. They also identified gene clusters that were active in stable asthma, but not the acute form of the disease. "Now that we know what genes are turned on during ...

Supercomputer Dedicated To Bioengineering, Computational Biology Installed

...ogical problems. The 210-node Dell PowerEdge Linux cluster capable of 2.6 trillion mathematical operations per second, the second most powerful computer cluster on campus, will be used to analyze everything from the behavior of protein molecules and subcellular...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...ctors in a signaling pathway that molds a targeted cluster of cells into a hair bud. During the budding proc... controls bud formation by first directing a small cluster of epithelial cells to form a placode, the pouch that forms hair plugs. The placode in turn directs ...

CoPub Mapper: mining MEDLINE based on search term co-publication

...genes and keywords and can be successfully used to cluster predefined groups of genes and microarray data. ...

Migratory songbirds have a specialized night-vision brain area

...es showed strikingly high activity in a particular cluster of cells located adjacent to a known visual pathwa...nlight conditions. To determine whether the brain cluster is really specialized for night-vision, the researchers performed the same gene expression analysis ...

The circadian clock: Understanding nature's timepiece

A cluster of brain cells less than half the size of a pencil eraser tells you when to wake up, when to be hungry and when it's time to go to sleep. The same cells also cause you to be disoriented after you've flown across multiple time zones. The human circad...

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...al strains. The answer, it seems, lies not in the cluster of genes known to produce the antibiotic, but in a mutation of another gene that co-regulates the timing of expression for the antibiotic-producing genes. The result? The mutant produces erythromycin for five days. The nonmutant produces it for only ...

Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot

...atients, activated white blood cells (eosinophils) cluster in the nasal and sinus mucus and scatter a toxic protein (major basic protein) onto the nasal and sinus membrane. While major basic protein was not distributed in the nasal and sinus tissue, the level of this protein in the mucus of chronic sinus inf...

Enzyme's newly discovered role may make it target for arthritis treatment

...utrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their cat...

Study finds adult stem cells can replicate

...utrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their cat...

Mosaic mouse technique offers a powerful new tool to study diseases and genetics

...ppens when a specific gene is removed from a small cluster of cells in a living animal. With MADM, cells carrying an altered gene of interest actually turn green for easier observation. "We use a green fluorescent protein," Luo says. "So now if you mutate a gene, you'll know in which cell the normal gene is...

Bioinformatics reveals new gene regulation system

...r-absent pattern as the NrdR-box. Only one protein cluster matched the pattern, and it represented a family of proteins that shared traits of transcription factors. To strengthen the prediction that these proteins were the transcription factors that bind the NrdR-box, the team used another comparative genom...

The synapse is a shotgun

...se of a chick ciliary ganglion. This ganglion is a cluster of neurons that connect the brain to the iris of the eye. It launches the neurotransmitter acetylcholine from sac-like vesicles across the synapse to two types of receptors, called alpha 7 and alpha 3. Sejnowski and his colleagues transformed their ...

Past droughts geographically widespread in the West, according to tree-ring data

...ynchronous low-flow and high-flow events tended to cluster in time; The longest continuous period when both basins had extreme low-flow years was three years; Within any four-year period, having either high flow or low flow for two consecutive years occurred more than 20 percent of the time; ...

California computer scientists double volume of data in NIH biotech repository

...n the HAP algorithm on all dbSNP data sets using a cluster of 30 Intel Xeon processors provided by Calit2's National Science Foundation-funded OptIPuter project, in cooperation with the National Biomedical Computation Resource. Both organizations are based at UCSD. "In under 24 hours we were able to process ...

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