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Tag: "clotting" at biology news

U of M researcher examines newly emerging deadly disease

... it is typically characterized by the depletion of clotting factors in the blood and skin lesions. Purpura fulminans refers to widespread severe purpura with extensive tissue damage and sloughing of skin. Purpura are skin lesions that may be many centimeters in diameter caused by the leakage of blood into the...

Polymers with copper show promise for implanted sensors

... to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---generate nitric oxide. The nitric oxide produced in this layer of cells diffuses back into the blood vessel walls, wher...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

... (Feb. 15). The genetically altered mice lack the clotting substance factor IX, which in humans results in the hereditary bleeding disorder known as hemophilia B. This disease, much less common than hemophilia A, affects roughly one of every 35,000 people, primarily males. Although embryonic stem, or ES, ce...

Modified collagen could yield important medical applications

...ody's most common protein. Collagen promotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. Because it is non-toxic, dissolves naturally over time and rarely triggers rejection, collagen is commonly used in cosmetics, drug delivery systems and biocompatible...

Unusual antibiotics show promise against deadly 'superbugs'

...ody's most common protein. Collagen promotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. Because it is non-toxic, dissolves naturally over time and rarely triggers rejection, collagen is commonly used in cosmetics, drug delivery systems and biocompatible...

Redesigned protein accelerates blood clotting

...immune reactions," Fay said. Study Details Blood clotting involves more than a dozen clotting factors, many named with roman numerals. They form a cascade of chemical reactions inside blood vess...

NIH renews network focused on how genes influence drug responses

...y to medicines, including aspirin, used to prevent clotting and treat cardiovascular disease. (Alan R. Shuldiner, M.D., University of Maryland School of Medicine) Pharmacogenetics of Phase II Drug Metabolizing Enzymes --$12.6 million provided by NIGMS and NCI to characterize variations in genes encodin...

Promising therapies for haemophilia & heart disease

...on intravenous infusion of recombinant Factor VIII clotting protein. Professor Denisa Wagner and her Harvard ...a protein called P-selectin is important for blood clotting and altering its levels in the bloodstream by infusion appears to have great therapeutic potential."...

Genetic variation alters response to common anti-clotting drug

...the anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. Bu...earned that variations in a gene involved in blood clotting may explain why certain people require a lower or higher dose of warfarin to get its full benefits. ...

Ancient DNA helps UF researchers unearth potential hemophilia therapy

...g. In adult mice, the immune system normally views clotting protein as an invader and rejects it after traditional gene therapy. But UF researchers bypassed this immune response by performing gene therapy on mice within 24 hours of their birth, when their immune systems were still naive and would accept the p...

Polymer aids in blood clotting, pointing way to new treatment

... strategy for injuries or illnesses in which blood clotting is paramount to survival. In a paper to be publis...linear polymer known as polyphosphate speeds blood clotting and helps clots last longer. The paper appears online this week (Jan. 9-14) on the PNAS Web site. P...

Therapeutic prospects beyond Vioxx

...eptor all had the same effect ?a predisposition to clotting and an elevation of blood pressure. "This provides...Surprisingly, this appeared to reduce not only the clotting response, but also the rise in blood pressure caused by drugs like Celebrex. "Despite some chatter ...

Heparin prepared synthetically could replace animal-derived drug

...ex carbohydrate used to stop or prevent blood from clotting during medical procedures and treatments such as kidney dialysis, heart bypass surgery, stent implantation, indwelling catheters, knee and hip replacements, and deep vein thrombosis. The annual worldwide sales of heparin are estimated at $3 billion. ...

Taipan venom no snake oil

...hat are responsible for the pro coagulant or blood clotting agent called Factor X which could stem blood flow in a matter of seconds. A drug lead based on Factor X is being evaluated for clinical trials by bio pharmaceutical development company QRxPharma. "Australian snakes literally have a two-pronged atta...

Bones hold the key to blood renewal

...ne cells for fighting infection or cells for blood clotting and healing after injury. They can even respond to calls for help from organs such as the liver, migrating through the bloodstream to assist in repairing damage. The inner walls of the bones are also sites of intensive reconstruction. While one ty...

Ultra low-dose estrogen shown safe for post-menopausal women

...e the liver to produce substances that can lead to clotting or other adverse side effects. With a patch, you bypass the liver and go straight to the blood." Yaffe notes that since the WHI results were announced in 2004, "the field of estrogen research has been stymied. Hopefully, this study will start to tu...

Blood-compatible nanoscale materials possible using heparin

...therapeutic used to maintain blood flow or prevent clotting during medical procedures and treatments. The researchers demonstrated the composite heparin membrane with nanopores could work as an artificial kidney, or dialyzer, by filtering the blood and maintaining its flow. The presence of this blood-compati...

A transplant in time

...s at this time experienced completely normal blood clotting within a month or two of implantation. Although a number of problems would need to be surmounted before researchers could begin to think of applying the technique to humans, the Institute team's experiment is "proof of principle" ?evidence that ...

Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

...m. (Serum is the fluid from which blood cells and clotting factors have been removed.) Microscopic examination of the mosquito digestive tracts revealed that the antibodies were capable of completely eliminating the ookinettes. The study authors noted that Psv25H, a molecule similar to Pfs25, is found on ...

Inhibiting blood to save the brain

...eutic target, but this research shows that a blood clotting factor is an important player in MS." MS is ...raction with microglia, but not with platelets, so clotting wouldn't be impacted," said Akassoglou, adding that this potential MS therapy might also have applic...

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