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Tag: "clones" at biology news

Exploring the dark matter of the genome

...uences. The assembly was checked by matching it to clones of longer sequences. With the painstaking manual assembly taken as far as practical, the researchers mapped the sequences to their physical locations on the chromosomes. The sequence and maps prepared the ground for the next stage in the process, the...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...f RPL8 could stimulate a response in helper T cell clones and lymphocytes in four out of nine melanoma patients. The antigen created no response in cells taken from healthy donors. The study also showed that RPL8 might contain multiple regions that are capable of eliciting an immune response, suggesting ...

Lab research may one day lead to cancer treatment using patient's own immune cells

...rch project is called "Molecular studies of T cell clones for adoptive therapy." The pre-clinical trial, which means it will be used only in human tissues in the laboratory at this stage, will focus on identifying and harvesting T cells within the lymph nodes of patients, activating these T cells and grow...

No sex for 40 million years? No problem

...atures multiply by producing eggs that are genetic clones of the mother ?there are no males. Fossil records and molecular data show that bdelloid rotifers have been around for over 40 million years without sexually reproducing, and yet this new study has shown that they have evolved into distinct species. ...

Study of planarians offers insight into germ cell development

...ea also has the ability to reproduce asexually: It clones itself by means of fission. In looking at nanos in asexual individuals of this species, the researchers made the surprising discovery that these asexual individuals also express nanos and produce germ cells. Some other mechanism, as yet unknown, prev...

Cloned mice created from fully differentiated cells, a milestone in cloning research

... Previous attempts by scientists to produce animal clones directly from fully differentiated B cells, T cell...researchers have countered these are not bona fide clones because they possess chromosomes that are not identical to those of the original donor nucleus. Si...

Protein structure initiative launches new resources for the scientific community

...re and function. Researchers will be able to order clones for a minimal fee to cover processing, handling, and shipping. "Producing clones is an essential--and often time-consuming--step in the protein structure determination process," sai...

The power of one: A simpler, cheaper method for cell fusion

...vital technology for studying stem cells, creating clones and finding disease antibodies. "The only current method for electrofusion requires a very expensive and specialized electrical pulse generator," said Lu, a professor of agricultural and biological engineering at Purdue University. "My device uses...

Caterpillars tell us how bacteria cause disease

...ch covers most of the genome. They then inject the clones into Tobacco Hawkmoth Caterpillars to study the effects. Their work has shown that clones containing harmless genetic material are recognised and destroyed by the caterpillar's immune system...

PNAS study reveals why organs fail following massive trauma

...nnate system, that lymphocyte expands into army of clones specifically designed to attack the invader at hand. Unfortunately, lymphocytes too are capable of mistakenly destroying human cells. Thus, they have developed quality control mechanisms where they can choose to stop expanding into an army (anergy) o...

Scientists discover that ancient genes dictate flowering, fall bud set

...ith wild trees -- used consecutive years of poplar clones to study the multi-year delay in flowering. The Science paper reports their discovery that the expression of the FT gene increases with age. "This gradual increase might be part of the mechanism by which trees become adults," Brunner said. The Umea ...

Cloned stem cells prove identical to fertilized stem cells

...clones, in fact, die in utero or at birth. The few clones that make it into adulthood are often plagued by bizarre health complications. This is one reason why scientists generally believe that attempting to clone a human being is morally reprehensible. But are the cloned embryo's stem cells beleaguered b...

Scientists observe how a close bond activates the immune system

...ducing thousands of copies of itself. These T cell clones are capable of killing invaders outright and marshaling other cells to destroy them. In the new study, Gabriele Campi, a graduate student in Dr. Dustin's laboratory, and Kaspar Mossman, a graduate student of Dr. Groves's, created a synthetic dendr...

New study to explore cellular circuitry

...rotein present in the cell. What makes the set of clones useful is that each one manufactures large amounts of a single protein with a "tag" attached. One common application of the library is to separate the tagged proteins from all others in the cell, and then use the collection of tagged proteins to det...

Community MRSA is re-emergence of 1950s pandemic, study suggests

...s. Now researchers have shown that one of the key clones of community acquired MRSA (CA-MRSA) - infections picked up in public places which are resistant to treatment by powerful meticillin antibiotics - may have evolved from this earlier pandemic-causing strain. The researchers have sequenced key genes f...

Stem cell research - new cell lines

...alian first, UNSW researchers have developed three clones of cells from existing human embryonic stem cells. The breakthrough could lead to new treatments for diabetes, Parkinson's disease and spinal cord injury. "This cloning of cells involves a new technique, which is a very accurate way of extracting an...

Building a human kinase gene repository

...ly in oncology. This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-length, and can be sub-cloned by recombination based methodologies. This gene collection will be a useful resource for the scientific commu...

New tumor-suppressor gene discovered

...to make," Lai explains. Lai then generated mutant clones of this fly and found that they developed large tumors in many organs including the head, eye, wing, leg, and antenna. He also generated another mutant form of the mats gene--this time with a huge missing pie ce of genetic material caused by another ...

Cytoplasm affects the number of vertebrae in carp-goldfish clones

...initial rate of success in producing carp-goldfish clones is low--seven offspring in 501 attempts in this study--the authors believe that cross-species transplantation will lead to improved understanding of the contributions of the nucleus and egg cytoplasm to the growth and development of vertebrates. ...

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