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Tag: "class" at biology news

Brain inflammation may be friend, not foe, for Alzheimer's patients

...n Department of Dentistry and an expert on using a class of viruses known as lentiviruses for use in gene therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimer’s disease. ...

Hormone helps mice 'hibernate,' survive starvation

...ood, we believe this new pathway may lead to a new class of drugs that will impact many human conditions,” he said. ...

In mice, drug protects against diabetes and atherosclerosis

...ults suggest that targeting aP2 "can lead to a new class of powerful therapeutic agents to prevent and treat metabolic diseases such as type 2 diabetes and atherosclerosis." Said Hotamisligil, "This work turned out to be a perfect example of out-of-the box thinking, inter-institutional and inter-discipl...

U-M researchers discover gene switched off in cancer can be turned on

...ive Cancer Center. The finding could lead to a new class of targeted cancer therapies with potential to ben... a switch that had been turned off. Knowing that a class of drugs called histone deacetylase inhibitors, or HDAC inhibitors, can affect gene expression, the ...

Plastic that grows on trees

...rt fructose to HMF. Metal chlorides belong to a class of ionic-liquid-soluble materials called halides, which “in general work well for converting fructose to HMF,” Zhang said — but not so well when glucose is the initial stock. In fact, attempts at direct glucose conversion created so many impurities t...

Researchers demonstrate way to control tree height

...plant Arabidopsis, which inhibited the action of a class of plant-specific hormones known as gibberellic acids. These compounds are also used as sprays to control the size and fruiting of orchard trees. In trees, the compounds promote the elongation of plant cells – when they are inhibited, the cells do no...

New designer lipid-like peptide with lipid nanostructures for drug delivery systems

...ter-loving and water-hating, which represent a new class of designer materials using common amino acids, the same basic molecules from meat, beans and fruits. These lipid-like peptides have excellent potential to solubilize membrane proteins and enzymes, and - as now demonstrated - can also be utilized to...

Resistant HIV quickly hides in infants' cells

...everse transcriptase inhibitors (NNRTIs), a common class of antiretroviral drug used to treat HIV infection...d not stop. The news was not all bad: a different class of antiretroviral drugs, protease inhibitors (PIs), was effective in controlling HIV viral load and ...

Fat screen delivers plant-derived chemical with antidiabetic effects

...ations, convulsions, and tremors. The principal class of drugs prescribed for obesity-related diabetes, called thiazolidinediones or TZDs, work through a counterintuitive mechanism: they restore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome proliferator-...

Percutaneous aortic valve replacement safe, successful in high-risk patients

... After the procedure, patients were ranked in NYHA class II, on average, suggesting most were able to engage in a moderate level of activity before becoming short of breath....

Dinosaur hearing, listening to muscle noise, quieter cubicles

...new light on the behavior of this still-mysterious class of killer whales. (3aAB4) THE SOUNDSCAPE OF MODERNITY Acoustical developments in the 20th century forever altered the sounds that U.S. residents heard and their ways of listening. Modern acoustical inventions such as sound meters, microphones,...

Leukemia drug turns mini-molecules up, cancer genes down

...omyelocytic leukemia induces changes in an unusual class of small molecules called microRNAs (miRNAs) in the leukemic cells. The study also shows that three of these miRNAs inhibit the action of two genes important for cancer development, helping to explain how the drug works. The drug is called all-t...

Deconstructing brain wiring, one neuron at a time

...ice that will express specific genes in a targeted class of neurons, Callaway says. "All neurons of the type we select will then express the avian viral receptor and the rabies virus protein, allowing the modified rabies virus to infect targeted cells and spread only once to connecting cells," he adds. The...

Gut research yields new anti-cancer approach

...lorectal cancer cell lines. Despite the compound's class name, the anti-cancer effect has nothing to do wit...ity. That provides at least the hope that the drug class may not be prohibitively toxic in humans, the researchers said. More formal toxicity studies are un...

Using nanomagnets to enhance medical imaging

...and collaborators. Molecular nanomagnets are a new class of MRI contrast agents that may offer significant advantages, such as versatility in design, over the compounds used today. Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tiss...

Navigable nanotransport

...their shape resembles a hollowed-out pumpkin, this class of compounds was named after the plant genus of pumpkins, the cucurbitaceae. When the mini-pumpkins are linked together, they form an empty sphere with many tiny cavities on its surface. These "pockets" can be filled with certain nitrogen-containing ...

Hybrid molecule causes cancer cells to self-destruct

...led an application for a U.S. patent covering this class of compounds. ...

When your brain talks, your muscles don't always listen

... academics. At the University of Connecticut, a class on the biology of the brain introduced him to the nervous system and movement, and he was hooked. His interests were further piqued during a summer research experience, where he had the opportunity to work with wheelchair athletes. "People with se...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

... The mouse model chosen falls in a class of genetic diseases that afflicts 1 in 5000 patien... glycosphingolipid biosynthesis inhibitor, is in a class of compounds called "substrate reduction therapy" drugs.) This part of the study not only represente...

Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex

... seven T. rex peptides, five were for a particular class of collagen protein, collagen alpha I. The majority of these were found to be identical matches to amino acid sequences found in chicken collagen alpha I, while others matched newt and frog. For extinct species, the real goal is to find sequences ...

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