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Tag: "cisplatin" at biology news

Dealing deadly cancers a knockout punch

... study showed that the combination of reovirus and cisplatin was significantly more effective than cisplatin or reovirus alone at killing melanoma cancer cells in a mouse model. The investigators intend to ex...

Chemo combination improves survival in asbestos-related cancer

... In the study, patients receiving pemetrexed and cisplatin ?along with the vitamin supplements folic acid and...d nearly three months longer than patients getting cisplatin alone. Researchers led by John Green, M.D., at the Clatterbridge Center for Oncology in England,...

Molecular signature may identify cisplatin-sensitive breast tumors

...help identify patients most likely to benefit from cisplatin treatment. The findings will be tested in a clini...estion and to investigate the mechanism underlying cisplatin sensitivity. The research team focused on the function of p63, a protein that plays a role in no...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...ents on the trial had been treated with front line cisplatin combination chemotherapy, which failed to halt their disease. The clinical trial continues. No maximum tolerated dose has been established, Lu says. The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA...

New protein target may advance design of HIV and cancer drugs

...de effects compared to the very useful, but toxic, cisplatin and congeners. ...

Researchers find molecular 'brake' to cell death

...evels." Some chemotherapy drugs, like paclitaxel, cisplatin and etoposide, appear, coincidentally and perhaps inadvertently, to do both, and are very effective for specific cancers, he says. "But based on these new findings, we now have a new theoretical approach that can be used to help in the design of more...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...gs including the phase II clinical drug, BBR 3464, cisplatin and the new trinuclear platinum compound. In a lab...the treatment of cancer. The principal function of cisplatin is to bind to DNA. Platinum drugs are the largest class of anti-cancer drugs in the clinic and the m...

Enzyme crystal structure reveals 'unexpected' genome repair functions

...he success of the anticancer drug cisplatin, since cisplatin works by initiating the process of DNA repair, in ...chemotherapeutic agents like the chemotherapy drug cisplatin and radiation therapy work by essentially damaging DNA, any new understanding of the DNA repair mech...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

...ost effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts rep... Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approach to analog development is l...

Compound from Chinese medicine shows promise in head and neck cancer

...ntly used to treat this type of cancer. They found cisplatin killed cells with a mutant form of the protein p53...or cells to undergo programmed cell death. "These cisplatin resistant cells are exquisitely sensitive to (-)-gossypol. We can induce cell death in 70 percent to...

Researchers add new tool to tumor-treatment arsenal

...e results of combining a DNA-damaging agent called cisplatin with RAD001, a derivative of the immunosuppressive...atically killing the cancer cells when agents like cisplatin are introduced. "These findings provide the rationale for combining DNA-damaging agents with sensit...

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