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Tag: "circadian" at biology news

Beyond lithium for bipolar disorder

...nocked out show hyperactivity and defects in their circadian (day-night) behavior--both also characteristic of ... in animals, lithium has been shown to affect such circadian behavior. The protein also has been found to affect the activity of a key neurotransmitter, dopamine...

Effective Cancer Treatments Follow The Clock

... Cryptochrome gene, which, in contrast, `jams' the circadian clock at the most active point in its cycle.?/p...t and skeletal muscles. They operate on a 24-hour, circadian (Latin for "about a day") cycle that governs functions like sleeping and waking, rest and activity, ...

Wisconsin researchers identify sleep gene

...ng of when sleep occurs, which is regulated by the circadian system, Tononi notes. "The key molecular mechanisms controlling the circadian timing of sleep are well understood, but details about the homeostatic mechanism that regulates the ...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

...egon in Eugene, where he studied the mechanisms of circadian responses to light. He graduated with his bachelor...ellular and physiological mechanisms of vertebrate circadian rhythmicity, photoreceptor cell and molecular biology, and neurobiology. He is a member of the Socie...

After a time-shift, mixed signals from the circadian clock

...daptation by the neurons that comprise the central circadian clock--rather, that different components of the cl...ical analysis of cells that constitute the central circadian clock, the researchers made a surprising discovery: one part of the clock mechanism, represented by ...

The circadian clock: Understanding nature's timepiece

...ou've flown across multiple time zones. The human circadian clock, comprised of about 20,000 time-keeping cell...fety and economic benefits to figuring out how the circadian clock works," Antle says. "We are probably still at least 10 years away from developing a pill that ...

Discovery clarifies role of peptide in biological clock

...e found that the VIP mutants, indeed, can generate circadian rhythms, but the neurons can't synchronize to each...he believes these rhythmic neurons are specialized circadian pacemakers. "We suspect that at least some of the pace making cells in the SCN are VIP cells, and o...

Researchers Identify Cause of Early Bird Sleep Disorder

...e that was not previously shown in mammals to be a circadian rhythm gene," Ptacek explained. It's not yet clear...ant gene works to shift people's sleep time, their circadian rhythm, he added. But follow-on experiments in fruit flies and mice yielded results that are intrigu...

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

...ame research group to be an important regulator of circadian rhythms. The current study appears in the June 24 issue of the journal Science. "One of the keys to developing promising new therapies for debilitating neurodegenerative diseases lies in our understanding of how new neurons are created and integrate...

How monarch butterflies are wired for navigation

... sensors in the butterfly's eye and the creature's circadian clock--a critical link if the butterflies are to c...he researchers also pinpointed the location of the circadian clock in the butterfly brain. Such circadian clocks govern the approximately 24 hour activity and me...

Gene controlling circadian rhythms linked to drug addiction

...ound. The Clock gene not only controls the body's circadian rhythms, including sleep and wakefulness, body tem...t only did the mice experience problems with their circadian cycles - not sleeping as much and becoming more hyperactive - they also found cocaine more rewarding...

Temperature regulates circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behav...s and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about how daily temperature cyc...

A novel method to measure circadian cycles

... and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally ...fied fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had to rel...

What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock

...eurological ground between two other clocks -- the circadian clock that operates over the 24-hour light-dark cy... be localized in a discrete brain area, as can the circadian clock, which has clear inputs from the visual system and outputs that control the cyclic release of ...

Phenotype is influenced by nature, nurture and noise

...s that generate oscillations, sometimes in 24-hour circadian periods. Hasty, graduate students Dmitri Bratsun and Dmitri Volfson, and post-doctoral fellow Lev. S. Tsimring modified the Gillespie algorithm, a well known computer model of cellular reactions, by factoring in intrinsic noise and delays. Using the ...

A resetting signal keeps circadian rhythm on track in Drosophila fruit flies

... Hughes Medical Institute investigator. "However, circadian brain anatomy in mammals is much more complicated .... Flies are state-of-the art. Fortunately, their circadian clocks and even neural mechanisms are quite conserved with mammals." "We were curious about how the...

What can change in the brain? Electrical synapses, research shows

...at electrical synapses help set the brain's master circadian clock. ...

Travelers can avoid jet lag by resetting their body clocks

...lows travelers to avoid jet lag by resetting their circadian body clock before crossing several time zones, acc...d field settings to "phase advance" (resetting the circadian clock earlier in time so that all the circadian rhythms of the body occur earlier) thereby helping p...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...is sensitive to lithium and may help shed light on circadian rhythm disorders, including bipolar disorder. The ... at Penn, suggest a relationship between the human circadian clock and metabolism. Proteins are the gears of the clock, and not much is known about what regulate...

Darkness unveils vital metabolic fuel switch between sugar and fat

... animals dig deep burrows," said Lee, an expert in circadian rhythms. "They are constantly in the dark. Why not...mes and three strains of mutant mice with impaired circadian rhythms. The wild-type mice and two of the mutant strains exposed to regular light-dark cycles sh...

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